Association of nutritional status with osteoporosis, sarcopenia, and cognitive impairment in patients on hemodialysis
Background and Objectives: Inadequate nutrition in patients on hemodialysis causes various complications. This study aimed to investigate the association between nutritional status and risk of osteoporosis, sarcopenia, and cognitive impairment in patients on hemodialysis. Methods and Study Design: W...
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| Veröffentlicht in: | Asia Pacific Journal of Clinical Nutrition 2020-12, Vol.29 (4), p.712-723 |
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| container_title | Asia Pacific Journal of Clinical Nutrition |
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| creator | Lee, Heeryong Kim, Kipyo Ahn, Jeongmyung Lee, Dong Ryeol Lee, Jin Ho Hwang, Seun Deuk |
| description | Background and Objectives: Inadequate nutrition in patients on hemodialysis causes various complications. This study aimed to investigate the association between nutritional status and risk of osteoporosis, sarcopenia, and cognitive impairment in patients on hemodialysis.
Methods and Study Design: We enrolled 131 older patients on maintenance hemodialysis. Geriatric Nutrition Risk Index (GNRI) was used to assess nutritional status. Patients were divided into quartile groups according to the GNRI. Dual-energy X-ray absorptiometry, bioimpedance analysis and handgrip strength measurement, and the Korean version of the Montreal Cognitive Assessment were used to assess osteoporosis, sarcopenia, and cognitive impairment, respectively. Biochemical laboratory tests were also performed before mid-week hemodialysis session.
Results: Patients from higher GNRI quartiles had a lower prevalence of osteoporosis and sarcopenia. Cognitive impairment was not associated with any GNRI quartile. In the multivariable models, longer dialysis periods (OR 1.696, 95% CI 1.053-2.729, p=0.030) and higher intact parathyroid hormone levels (OR 3.136, 95% CI 1.781-5.518, p |
| doi_str_mv | 10.6133/apjcn.202012_29(4).0006 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_rmit_</sourceid><recordid>TN_cdi_proquest_miscellaneous_2473901697</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><airiti_id>09647058_202012_202101190001_202101190001_712_723</airiti_id><informt_id>10.3316/informit.646824982883607</informt_id><sourcerecordid>2473901697</sourcerecordid><originalsourceid>FETCH-LOGICAL-a477t-a9bb79edea55273269c1eeb639bba964d7252a46e00caef9ff64e16dc865534c3</originalsourceid><addsrcrecordid>eNqNkktv1DAUhS0EokPhL4AlNkVqBr9ixxKbqgIKqsQG1tYdx-l4lNjBdkD99zhMqwIrVn5998j33IPQK0q2knL-FuaDDVtGGKHMMH0m3mwJIfIR2lAhSCOJUI_RhmgpGkXa7gQ9y_lQCS5I-xSdcM6V4rLdoOUi52g9FB8DjgMOS0l-PcCIc4GyZPzTlz2Oubg4xxSzz-c4Q7JxdsHDOYbQYxtvQq364bCfZvBpcqFgH_Bcdes24yq-d1PsPYy3VeE5ejLAmN2Lu_UUffvw_uvlVXP95eOny4vrBoRSpQG92yntegdtyxRnUlvq3E7yeg-1t16xloGQjhALbtDDIIWjsredbFsuLD9FZ0fdOcXvi8vFTD5bN44QXFyyYUJxTajUqqKv_0EPcUnVhpXSvBVEUVmpl3fUsptcb-bkJ0i35t7QCrw7Amnyxdg4js6uduYDlGwoqSSVxoch_gakkF2V71jXcUnWX3z-oxxmGIrJrrq9f6iJ6cb00f-P2NVRrE6kTuehoTUXayzMfYAIo4RSXQNC_z6o-qoY578AaLW8-w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2493540716</pqid></control><display><type>article</type><title>Association of nutritional status with osteoporosis, sarcopenia, and cognitive impairment in patients on hemodialysis</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Lee, Heeryong ; Kim, Kipyo ; Ahn, Jeongmyung ; Lee, Dong Ryeol ; Lee, Jin Ho ; Hwang, Seun Deuk</creator><creatorcontrib>Lee, Heeryong ; Kim, Kipyo ; Ahn, Jeongmyung ; Lee, Dong Ryeol ; Lee, Jin Ho ; Hwang, Seun Deuk</creatorcontrib><description>Background and Objectives: Inadequate nutrition in patients on hemodialysis causes various complications. This study aimed to investigate the association between nutritional status and risk of osteoporosis, sarcopenia, and cognitive impairment in patients on hemodialysis.
Methods and Study Design: We enrolled 131 older patients on maintenance hemodialysis. Geriatric Nutrition Risk Index (GNRI) was used to assess nutritional status. Patients were divided into quartile groups according to the GNRI. Dual-energy X-ray absorptiometry, bioimpedance analysis and handgrip strength measurement, and the Korean version of the Montreal Cognitive Assessment were used to assess osteoporosis, sarcopenia, and cognitive impairment, respectively. Biochemical laboratory tests were also performed before mid-week hemodialysis session.
Results: Patients from higher GNRI quartiles had a lower prevalence of osteoporosis and sarcopenia. Cognitive impairment was not associated with any GNRI quartile. In the multivariable models, longer dialysis periods (OR 1.696, 95% CI 1.053-2.729, p=0.030) and higher intact parathyroid hormone levels (OR 3.136, 95% CI 1.781-5.518, p<0.001) were significantly associated with osteoporosis risk. GNRI quartile 2 (OR 0.064, 95% CI 0.005-0.883, compared to quartile 1, p=0.040) and higher hemoglobin A1c levels (OR 3.728, 95% CI 1.033-86.4, p=0.043) were associated with a higher sarcopenia risk. Lower hemoglobin levels (OR 0.585, 95% CI 0.360-0.950, p=0.030) were associated with a higher risk of cognitive impairment.
Conclusions: In patients on hemodialysis, inadequate nutrition was associated with the risk of osteoporosis and sarcopenia, but not cognitive impairment. Proper nutritional assessment and management in these patients could prevent complications related to bone and muscle loss.</description><identifier>ISSN: 0964-7058</identifier><identifier>EISSN: 1440-6047</identifier><identifier>DOI: 10.6133/apjcn.202012_29(4).0006</identifier><identifier>PMID: 33377365</identifier><language>eng</language><publisher>Clayton, Vic: HEC Press</publisher><subject>Analysis ; Bone density ; Care ; Hemodialysis ; Mortality ; Nutrition ; Nutritional aspects ; Osteoporosis ; Parathyroid hormone ; Patients ; Sarcopenia ; Womens health</subject><ispartof>Asia Pacific Journal of Clinical Nutrition, 2020-12, Vol.29 (4), p.712-723</ispartof><rights>Copyright HEC Press Dec 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a477t-a9bb79edea55273269c1eeb639bba964d7252a46e00caef9ff64e16dc865534c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33377365$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Heeryong</creatorcontrib><creatorcontrib>Kim, Kipyo</creatorcontrib><creatorcontrib>Ahn, Jeongmyung</creatorcontrib><creatorcontrib>Lee, Dong Ryeol</creatorcontrib><creatorcontrib>Lee, Jin Ho</creatorcontrib><creatorcontrib>Hwang, Seun Deuk</creatorcontrib><title>Association of nutritional status with osteoporosis, sarcopenia, and cognitive impairment in patients on hemodialysis</title><title>Asia Pacific Journal of Clinical Nutrition</title><addtitle>Asia Pac J Clin Nutr</addtitle><description>Background and Objectives: Inadequate nutrition in patients on hemodialysis causes various complications. This study aimed to investigate the association between nutritional status and risk of osteoporosis, sarcopenia, and cognitive impairment in patients on hemodialysis.
Methods and Study Design: We enrolled 131 older patients on maintenance hemodialysis. Geriatric Nutrition Risk Index (GNRI) was used to assess nutritional status. Patients were divided into quartile groups according to the GNRI. Dual-energy X-ray absorptiometry, bioimpedance analysis and handgrip strength measurement, and the Korean version of the Montreal Cognitive Assessment were used to assess osteoporosis, sarcopenia, and cognitive impairment, respectively. Biochemical laboratory tests were also performed before mid-week hemodialysis session.
Results: Patients from higher GNRI quartiles had a lower prevalence of osteoporosis and sarcopenia. Cognitive impairment was not associated with any GNRI quartile. In the multivariable models, longer dialysis periods (OR 1.696, 95% CI 1.053-2.729, p=0.030) and higher intact parathyroid hormone levels (OR 3.136, 95% CI 1.781-5.518, p<0.001) were significantly associated with osteoporosis risk. GNRI quartile 2 (OR 0.064, 95% CI 0.005-0.883, compared to quartile 1, p=0.040) and higher hemoglobin A1c levels (OR 3.728, 95% CI 1.033-86.4, p=0.043) were associated with a higher sarcopenia risk. Lower hemoglobin levels (OR 0.585, 95% CI 0.360-0.950, p=0.030) were associated with a higher risk of cognitive impairment.
Conclusions: In patients on hemodialysis, inadequate nutrition was associated with the risk of osteoporosis and sarcopenia, but not cognitive impairment. Proper nutritional assessment and management in these patients could prevent complications related to bone and muscle loss.</description><subject>Analysis</subject><subject>Bone density</subject><subject>Care</subject><subject>Hemodialysis</subject><subject>Mortality</subject><subject>Nutrition</subject><subject>Nutritional aspects</subject><subject>Osteoporosis</subject><subject>Parathyroid hormone</subject><subject>Patients</subject><subject>Sarcopenia</subject><subject>Womens health</subject><issn>0964-7058</issn><issn>1440-6047</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNqNkktv1DAUhS0EokPhL4AlNkVqBr9ixxKbqgIKqsQG1tYdx-l4lNjBdkD99zhMqwIrVn5998j33IPQK0q2knL-FuaDDVtGGKHMMH0m3mwJIfIR2lAhSCOJUI_RhmgpGkXa7gQ9y_lQCS5I-xSdcM6V4rLdoOUi52g9FB8DjgMOS0l-PcCIc4GyZPzTlz2Oubg4xxSzz-c4Q7JxdsHDOYbQYxtvQq364bCfZvBpcqFgH_Bcdes24yq-d1PsPYy3VeE5ejLAmN2Lu_UUffvw_uvlVXP95eOny4vrBoRSpQG92yntegdtyxRnUlvq3E7yeg-1t16xloGQjhALbtDDIIWjsredbFsuLD9FZ0fdOcXvi8vFTD5bN44QXFyyYUJxTajUqqKv_0EPcUnVhpXSvBVEUVmpl3fUsptcb-bkJ0i35t7QCrw7Amnyxdg4js6uduYDlGwoqSSVxoch_gakkF2V71jXcUnWX3z-oxxmGIrJrrq9f6iJ6cb00f-P2NVRrE6kTuehoTUXayzMfYAIo4RSXQNC_z6o-qoY578AaLW8-w</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Lee, Heeryong</creator><creator>Kim, Kipyo</creator><creator>Ahn, Jeongmyung</creator><creator>Lee, Dong Ryeol</creator><creator>Lee, Jin Ho</creator><creator>Hwang, Seun Deuk</creator><general>HEC Press</general><scope>188</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BVBZV</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20201201</creationdate><title>Association of nutritional status with osteoporosis, sarcopenia, and cognitive impairment in patients on hemodialysis</title><author>Lee, Heeryong ; Kim, Kipyo ; Ahn, Jeongmyung ; Lee, Dong Ryeol ; Lee, Jin Ho ; Hwang, Seun Deuk</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a477t-a9bb79edea55273269c1eeb639bba964d7252a46e00caef9ff64e16dc865534c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Analysis</topic><topic>Bone density</topic><topic>Care</topic><topic>Hemodialysis</topic><topic>Mortality</topic><topic>Nutrition</topic><topic>Nutritional aspects</topic><topic>Osteoporosis</topic><topic>Parathyroid hormone</topic><topic>Patients</topic><topic>Sarcopenia</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Heeryong</creatorcontrib><creatorcontrib>Kim, Kipyo</creatorcontrib><creatorcontrib>Ahn, Jeongmyung</creatorcontrib><creatorcontrib>Lee, Dong Ryeol</creatorcontrib><creatorcontrib>Lee, Jin Ho</creatorcontrib><creatorcontrib>Hwang, Seun Deuk</creatorcontrib><collection>Airiti Library</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>East & South Asia Database</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Asia Pacific Journal of Clinical Nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Heeryong</au><au>Kim, Kipyo</au><au>Ahn, Jeongmyung</au><au>Lee, Dong Ryeol</au><au>Lee, Jin Ho</au><au>Hwang, Seun Deuk</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of nutritional status with osteoporosis, sarcopenia, and cognitive impairment in patients on hemodialysis</atitle><jtitle>Asia Pacific Journal of Clinical Nutrition</jtitle><addtitle>Asia Pac J Clin Nutr</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>29</volume><issue>4</issue><spage>712</spage><epage>723</epage><pages>712-723</pages><issn>0964-7058</issn><eissn>1440-6047</eissn><abstract>Background and Objectives: Inadequate nutrition in patients on hemodialysis causes various complications. This study aimed to investigate the association between nutritional status and risk of osteoporosis, sarcopenia, and cognitive impairment in patients on hemodialysis.
Methods and Study Design: We enrolled 131 older patients on maintenance hemodialysis. Geriatric Nutrition Risk Index (GNRI) was used to assess nutritional status. Patients were divided into quartile groups according to the GNRI. Dual-energy X-ray absorptiometry, bioimpedance analysis and handgrip strength measurement, and the Korean version of the Montreal Cognitive Assessment were used to assess osteoporosis, sarcopenia, and cognitive impairment, respectively. Biochemical laboratory tests were also performed before mid-week hemodialysis session.
Results: Patients from higher GNRI quartiles had a lower prevalence of osteoporosis and sarcopenia. Cognitive impairment was not associated with any GNRI quartile. In the multivariable models, longer dialysis periods (OR 1.696, 95% CI 1.053-2.729, p=0.030) and higher intact parathyroid hormone levels (OR 3.136, 95% CI 1.781-5.518, p<0.001) were significantly associated with osteoporosis risk. GNRI quartile 2 (OR 0.064, 95% CI 0.005-0.883, compared to quartile 1, p=0.040) and higher hemoglobin A1c levels (OR 3.728, 95% CI 1.033-86.4, p=0.043) were associated with a higher sarcopenia risk. Lower hemoglobin levels (OR 0.585, 95% CI 0.360-0.950, p=0.030) were associated with a higher risk of cognitive impairment.
Conclusions: In patients on hemodialysis, inadequate nutrition was associated with the risk of osteoporosis and sarcopenia, but not cognitive impairment. Proper nutritional assessment and management in these patients could prevent complications related to bone and muscle loss.</abstract><cop>Clayton, Vic</cop><pub>HEC Press</pub><pmid>33377365</pmid><doi>10.6133/apjcn.202012_29(4).0006</doi><tpages>12</tpages></addata></record> |
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| subjects | Analysis Bone density Care Hemodialysis Mortality Nutrition Nutritional aspects Osteoporosis Parathyroid hormone Patients Sarcopenia Womens health |
| title | Association of nutritional status with osteoporosis, sarcopenia, and cognitive impairment in patients on hemodialysis |
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