Epidermal barrier changes in patients with psoriasis: The role of phototherapy
Background Some skin diseases may modify epidermal barrier function. Psoriasis is a chronic multi‐systemic inflammatory disease that affects the epidermal barrier. Phototherapy is an option for treating psoriasis, but little is known about how epidermal barrier function is modified by phototherapy i...
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| Veröffentlicht in: | Photodermatology, photoimmunology & photomedicine photoimmunology & photomedicine, 2021-07, Vol.37 (4), p.285-292 |
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| creator | Montero‐Vilchez, Trinidad Soler‐Góngora, Miguel Martínez‐López, Antonio Ana, Fernández‐González Buendía‐Eisman, Agustín Molina‐Leyva, Alejandro Arias‐Santiago, Salvador |
| description | Background
Some skin diseases may modify epidermal barrier function. Psoriasis is a chronic multi‐systemic inflammatory disease that affects the epidermal barrier. Phototherapy is an option for treating psoriasis, but little is known about how epidermal barrier function is modified by phototherapy in psoriatic patients.
Objectives
(a) To compare skin homeostasis between involved and uninvolved skin in psoriatic patients with healthy controls (b) To evaluate changes in the epidermal barrier function in psoriatic patients treated with phototherapy.
Methods
Sixty patients with plaque‐type psoriasis and sixty gender and age‐matched healthy controls were enrolled. Temperature, transepidermal water loss (TEWL), stratum corneum hydration (SCH), pH, elasticity, erythema and melanin index were measured using non‐invasive tools in the healthy control and involved and uninvolved psoriatic skin before and after phototherapy.
Results
Healthy controls had lower TEWL and erythema index and higher SCH than psoriatic patients, both at uninvolved psoriatic skin and psoriasis plaques. TEWL was higher at psoriasis plaques than at uninvolved skin (19.20 vs 11.57 g/h/m2; P |
| doi_str_mv | 10.1111/phpp.12650 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2473900332</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2473900332</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3290-7254594b6e6d8a8c61c2778748ffd7b0f58827d7aad112f6cdee71f803b827663</originalsourceid><addsrcrecordid>eNp9kMFLwzAUh4Mobk4v_gGSowidL0nbpN5kTCcM3WGeS9q-2kjXxqRj7L-3s9Oj7_KDx8d3-Ai5ZjBl_d3bytop43EEJ2TMYoAApGKnZAwJREEolBiRC-8_ASAMgZ2TkRBCyijkY_I6t6ZAt9E1zbRzBh3NK918oKemoVZ3BpvO053pKmp964z2xj_QdYXUtTXStqS2aru2q9Bpu78kZ6WuPV4dd0Len-br2SJYvj2_zB6XQS54AoHkURglYRZjXCit8pjlXEolQ1WWhcygjJTispBaF4zxMs4LRMlKBSLr_3EsJuR28FrXfm3Rd-nG-BzrWjfYbn3KQykSACF4j94NaO5a7x2WqXVmo90-ZZAe-qWHfulPvx6-OXq32QaLP_Q3WA-wAdiZGvf_qNLVYrUapN9lJHqz</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2473900332</pqid></control><display><type>article</type><title>Epidermal barrier changes in patients with psoriasis: The role of phototherapy</title><source>Wiley Online Library All Journals</source><creator>Montero‐Vilchez, Trinidad ; Soler‐Góngora, Miguel ; Martínez‐López, Antonio ; Ana, Fernández‐González ; Buendía‐Eisman, Agustín ; Molina‐Leyva, Alejandro ; Arias‐Santiago, Salvador</creator><creatorcontrib>Montero‐Vilchez, Trinidad ; Soler‐Góngora, Miguel ; Martínez‐López, Antonio ; Ana, Fernández‐González ; Buendía‐Eisman, Agustín ; Molina‐Leyva, Alejandro ; Arias‐Santiago, Salvador</creatorcontrib><description>Background
Some skin diseases may modify epidermal barrier function. Psoriasis is a chronic multi‐systemic inflammatory disease that affects the epidermal barrier. Phototherapy is an option for treating psoriasis, but little is known about how epidermal barrier function is modified by phototherapy in psoriatic patients.
Objectives
(a) To compare skin homeostasis between involved and uninvolved skin in psoriatic patients with healthy controls (b) To evaluate changes in the epidermal barrier function in psoriatic patients treated with phototherapy.
Methods
Sixty patients with plaque‐type psoriasis and sixty gender and age‐matched healthy controls were enrolled. Temperature, transepidermal water loss (TEWL), stratum corneum hydration (SCH), pH, elasticity, erythema and melanin index were measured using non‐invasive tools in the healthy control and involved and uninvolved psoriatic skin before and after phototherapy.
Results
Healthy controls had lower TEWL and erythema index and higher SCH than psoriatic patients, both at uninvolved psoriatic skin and psoriasis plaques. TEWL was higher at psoriasis plaques than at uninvolved skin (19.20 vs 11.57 g/h/m2; P < .001). Following phototherapy, a decreasing trend was observed for TEWL, of 1.03 (SD 0.75) and 0.97 (SD 0.81) g/h/m2 for uninvolved and involved skin respectively. SCH was significantly lower at psoriatic plaques than at uninvolved skin (7.32 vs 36.62Arbitrary Units [AU]; P < .001). SCH increased by 1.15AU (SD 0.26) on psoriatic plaques after the phototherapy session (P < .001).
Conclusion
Psoriatic plaques showed epidermal barrier dysfunction compared to uninvolved skin and healthy controls. Phototherapy may improve epidermal barrier function in psoriatic patients. SCH increased after a phototherapy session on the psoriatic plaques.</description><identifier>ISSN: 0905-4383</identifier><identifier>EISSN: 1600-0781</identifier><identifier>DOI: 10.1111/phpp.12650</identifier><identifier>PMID: 33377542</identifier><language>eng</language><publisher>England</publisher><subject>homeostasis ; phototherapy ; psoriasis ; skin physiology ; transepidermal water loss</subject><ispartof>Photodermatology, photoimmunology & photomedicine, 2021-07, Vol.37 (4), p.285-292</ispartof><rights>2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3290-7254594b6e6d8a8c61c2778748ffd7b0f58827d7aad112f6cdee71f803b827663</citedby><cites>FETCH-LOGICAL-c3290-7254594b6e6d8a8c61c2778748ffd7b0f58827d7aad112f6cdee71f803b827663</cites><orcidid>0000-0003-4035-7955 ; 0000-0003-0304-7317</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fphpp.12650$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fphpp.12650$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33377542$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Montero‐Vilchez, Trinidad</creatorcontrib><creatorcontrib>Soler‐Góngora, Miguel</creatorcontrib><creatorcontrib>Martínez‐López, Antonio</creatorcontrib><creatorcontrib>Ana, Fernández‐González</creatorcontrib><creatorcontrib>Buendía‐Eisman, Agustín</creatorcontrib><creatorcontrib>Molina‐Leyva, Alejandro</creatorcontrib><creatorcontrib>Arias‐Santiago, Salvador</creatorcontrib><title>Epidermal barrier changes in patients with psoriasis: The role of phototherapy</title><title>Photodermatology, photoimmunology & photomedicine</title><addtitle>Photodermatol Photoimmunol Photomed</addtitle><description>Background
Some skin diseases may modify epidermal barrier function. Psoriasis is a chronic multi‐systemic inflammatory disease that affects the epidermal barrier. Phototherapy is an option for treating psoriasis, but little is known about how epidermal barrier function is modified by phototherapy in psoriatic patients.
Objectives
(a) To compare skin homeostasis between involved and uninvolved skin in psoriatic patients with healthy controls (b) To evaluate changes in the epidermal barrier function in psoriatic patients treated with phototherapy.
Methods
Sixty patients with plaque‐type psoriasis and sixty gender and age‐matched healthy controls were enrolled. Temperature, transepidermal water loss (TEWL), stratum corneum hydration (SCH), pH, elasticity, erythema and melanin index were measured using non‐invasive tools in the healthy control and involved and uninvolved psoriatic skin before and after phototherapy.
Results
Healthy controls had lower TEWL and erythema index and higher SCH than psoriatic patients, both at uninvolved psoriatic skin and psoriasis plaques. TEWL was higher at psoriasis plaques than at uninvolved skin (19.20 vs 11.57 g/h/m2; P < .001). Following phototherapy, a decreasing trend was observed for TEWL, of 1.03 (SD 0.75) and 0.97 (SD 0.81) g/h/m2 for uninvolved and involved skin respectively. SCH was significantly lower at psoriatic plaques than at uninvolved skin (7.32 vs 36.62Arbitrary Units [AU]; P < .001). SCH increased by 1.15AU (SD 0.26) on psoriatic plaques after the phototherapy session (P < .001).
Conclusion
Psoriatic plaques showed epidermal barrier dysfunction compared to uninvolved skin and healthy controls. Phototherapy may improve epidermal barrier function in psoriatic patients. SCH increased after a phototherapy session on the psoriatic plaques.</description><subject>homeostasis</subject><subject>phototherapy</subject><subject>psoriasis</subject><subject>skin physiology</subject><subject>transepidermal water loss</subject><issn>0905-4383</issn><issn>1600-0781</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kMFLwzAUh4Mobk4v_gGSowidL0nbpN5kTCcM3WGeS9q-2kjXxqRj7L-3s9Oj7_KDx8d3-Ai5ZjBl_d3bytop43EEJ2TMYoAApGKnZAwJREEolBiRC-8_ASAMgZ2TkRBCyijkY_I6t6ZAt9E1zbRzBh3NK918oKemoVZ3BpvO053pKmp964z2xj_QdYXUtTXStqS2aru2q9Bpu78kZ6WuPV4dd0Len-br2SJYvj2_zB6XQS54AoHkURglYRZjXCit8pjlXEolQ1WWhcygjJTispBaF4zxMs4LRMlKBSLr_3EsJuR28FrXfm3Rd-nG-BzrWjfYbn3KQykSACF4j94NaO5a7x2WqXVmo90-ZZAe-qWHfulPvx6-OXq32QaLP_Q3WA-wAdiZGvf_qNLVYrUapN9lJHqz</recordid><startdate>202107</startdate><enddate>202107</enddate><creator>Montero‐Vilchez, Trinidad</creator><creator>Soler‐Góngora, Miguel</creator><creator>Martínez‐López, Antonio</creator><creator>Ana, Fernández‐González</creator><creator>Buendía‐Eisman, Agustín</creator><creator>Molina‐Leyva, Alejandro</creator><creator>Arias‐Santiago, Salvador</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4035-7955</orcidid><orcidid>https://orcid.org/0000-0003-0304-7317</orcidid></search><sort><creationdate>202107</creationdate><title>Epidermal barrier changes in patients with psoriasis: The role of phototherapy</title><author>Montero‐Vilchez, Trinidad ; Soler‐Góngora, Miguel ; Martínez‐López, Antonio ; Ana, Fernández‐González ; Buendía‐Eisman, Agustín ; Molina‐Leyva, Alejandro ; Arias‐Santiago, Salvador</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3290-7254594b6e6d8a8c61c2778748ffd7b0f58827d7aad112f6cdee71f803b827663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>homeostasis</topic><topic>phototherapy</topic><topic>psoriasis</topic><topic>skin physiology</topic><topic>transepidermal water loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Montero‐Vilchez, Trinidad</creatorcontrib><creatorcontrib>Soler‐Góngora, Miguel</creatorcontrib><creatorcontrib>Martínez‐López, Antonio</creatorcontrib><creatorcontrib>Ana, Fernández‐González</creatorcontrib><creatorcontrib>Buendía‐Eisman, Agustín</creatorcontrib><creatorcontrib>Molina‐Leyva, Alejandro</creatorcontrib><creatorcontrib>Arias‐Santiago, Salvador</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Photodermatology, photoimmunology & photomedicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Montero‐Vilchez, Trinidad</au><au>Soler‐Góngora, Miguel</au><au>Martínez‐López, Antonio</au><au>Ana, Fernández‐González</au><au>Buendía‐Eisman, Agustín</au><au>Molina‐Leyva, Alejandro</au><au>Arias‐Santiago, Salvador</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidermal barrier changes in patients with psoriasis: The role of phototherapy</atitle><jtitle>Photodermatology, photoimmunology & photomedicine</jtitle><addtitle>Photodermatol Photoimmunol Photomed</addtitle><date>2021-07</date><risdate>2021</risdate><volume>37</volume><issue>4</issue><spage>285</spage><epage>292</epage><pages>285-292</pages><issn>0905-4383</issn><eissn>1600-0781</eissn><abstract>Background
Some skin diseases may modify epidermal barrier function. Psoriasis is a chronic multi‐systemic inflammatory disease that affects the epidermal barrier. Phototherapy is an option for treating psoriasis, but little is known about how epidermal barrier function is modified by phototherapy in psoriatic patients.
Objectives
(a) To compare skin homeostasis between involved and uninvolved skin in psoriatic patients with healthy controls (b) To evaluate changes in the epidermal barrier function in psoriatic patients treated with phototherapy.
Methods
Sixty patients with plaque‐type psoriasis and sixty gender and age‐matched healthy controls were enrolled. Temperature, transepidermal water loss (TEWL), stratum corneum hydration (SCH), pH, elasticity, erythema and melanin index were measured using non‐invasive tools in the healthy control and involved and uninvolved psoriatic skin before and after phototherapy.
Results
Healthy controls had lower TEWL and erythema index and higher SCH than psoriatic patients, both at uninvolved psoriatic skin and psoriasis plaques. TEWL was higher at psoriasis plaques than at uninvolved skin (19.20 vs 11.57 g/h/m2; P < .001). Following phototherapy, a decreasing trend was observed for TEWL, of 1.03 (SD 0.75) and 0.97 (SD 0.81) g/h/m2 for uninvolved and involved skin respectively. SCH was significantly lower at psoriatic plaques than at uninvolved skin (7.32 vs 36.62Arbitrary Units [AU]; P < .001). SCH increased by 1.15AU (SD 0.26) on psoriatic plaques after the phototherapy session (P < .001).
Conclusion
Psoriatic plaques showed epidermal barrier dysfunction compared to uninvolved skin and healthy controls. Phototherapy may improve epidermal barrier function in psoriatic patients. SCH increased after a phototherapy session on the psoriatic plaques.</abstract><cop>England</cop><pmid>33377542</pmid><doi>10.1111/phpp.12650</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-4035-7955</orcidid><orcidid>https://orcid.org/0000-0003-0304-7317</orcidid></addata></record> |
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| source | Wiley Online Library All Journals |
| subjects | homeostasis phototherapy psoriasis skin physiology transepidermal water loss |
| title | Epidermal barrier changes in patients with psoriasis: The role of phototherapy |
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