Butyl methyl imidazolium silica sulfate (BMIm)SS: A novel hybrid nano‐catalyst for highly efficient synthesis of new 1,2-diol monoesters of ibuprofen as the novel prodrugs of ibuprofen having potent analgesic property

[Display omitted] •Novel nano-hybride catalyst (BMIm)SS is prepared and characterized.•1,2-diol monoester of IBP is obtained from epoxide and IBP catalyzed by (BMIm)SS.•1,2-diol monoesters of IBP show potent analgesic activity using formalin test.•Docking indicates strong binding of compounds in an...

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Veröffentlicht in:	Bioorganic chemistry 2021-02, Vol.107, p.104570-104570, Article 104570
Hauptverfasser:	Soltani Rad, Mohammad Navid, Behrouz, Somayeh, Atashbasteh, Esmaeil, Hashemi, Seyedeh-Sara
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2-diol monoesters [BMIm]SS Analgesic Cyclooxygenase Formalin test Ibuprofen NSAIDs
Online-Zugang:	Volltext
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