Immune characteristics of renal allograft donors with mesangial IgA deposition

•Our data showed that 26% blood-related donors had mesangial IgA deposition.•IgA deposited in healthy donors contains galactose-deficient IgA1.•Levels of serum IgG anti-glycan antibodies in donors with IgA deposition were between healthy control and patients with IgAN. There are few studies describi...

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Veröffentlicht in:	International immunopharmacology 2021-02, Vol.91, p.107282-107282, Article 107282
Hauptverfasser:	Wang, Zi, Zhang, Xue, Han, Wenke, Yu, Guizhen, Ying, Zewei, Xu, Xin, Wang, Manliu, Zhou, Xujie, Lv, Jicheng, Zhang, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Blood Cadavers Deposition Donor Electron microscopy Enzyme-linked immunosorbent assay Gadolinium Galactose Galactose-deficient IgA1 (Gd-IgA1) Glycan IgA nephropathy Immunofluorescence Immunoglobulin A Immunoglobulin A nephropathy (IgAN) Immunoglobulin G Kidney transplantation Kidneys Latent mesangial IgA deposition Mesangium Monoclonal antibodies Organ donors Zero-hour renal biopsy
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