The PGE2 receptor EP3 plays a positive role in the activation of hypothalamic-pituitary-adrenal axis and neuronal activity in the hypothalamus under immobilization stress

•The effect of PGE2 receptor EP3 on the stress-induced change of HPA axis activation and neuronal activity were studied.•Immobilization stress enhances the gene and protein expression of EP3 receptor in the hypothalamus.•EP3 receptor antagonist decreases stress-related increases in the activation of...

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Veröffentlicht in:	Brain research bulletin 2021-03, Vol.168, p.45-51
Hauptverfasser:	Lv, Leyuan, Bai, Dongying, Ma, Yihong, Liu, Kexin, Ma, Yanbo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dinoprostone - metabolism EP3 receptor HPA axis activation Hypothalamo-Hypophyseal System - metabolism Hypothalamo-Hypophyseal System - physiopathology Hypothalamus Hypothalamus - metabolism Immobilization stress Male Neuronal activity Neurons - metabolism Paraventricular Hypothalamic Nucleus - drug effects Pituitary-Adrenal System - metabolism Pituitary-Adrenal System - physiopathology Rats Receptors, Prostaglandin E - metabolism Receptors, Prostaglandin E, EP3 Subtype - metabolism Stress, Mechanical
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