CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction

Vascular calcification is a critical pathology associated with increased cardiovascular event risk, but there are no Food and Drug Administration-approved anticalcific therapies. We hypothesized and validated that an unbiased screening approach would identify novel mediators of human vascular calcif...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2021-02, Vol.41 (2), p.755-768
Hauptverfasser:	Okui, Takehito, Iwashita, Masaya, Rogers, Maximillian A., Halu, Arda, Atkins, Samantha K., Kuraoka, Shiori, Abdelhamid, Ilyes, Higashi, Hideyuki, Ramsaroop, Ashisha, Aikawa, Masanori, Singh, Sasha A., Aikawa, Elena
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Atherosclerosis - enzymology Atherosclerosis - genetics Atherosclerosis - pathology Atherosclerosis - prevention & control Carnitine Acyltransferases - genetics Carnitine Acyltransferases - metabolism Cells, Cultured Disease Models, Animal Energy Metabolism Fatty Acids - metabolism Female Fibrosis Humans Male Mice Mice, Inbred C57BL Mice, Knockout Middle Aged Mitochondria - enzymology Mitochondria - pathology Muscle, Smooth, Vascular - enzymology Muscle, Smooth, Vascular - pathology Myocytes, Smooth Muscle - enzymology Myocytes, Smooth Muscle - pathology Osteogenesis Proteome Proteomics Receptors, LDL - genetics Receptors, LDL - metabolism Signal Transduction Vascular Calcification - enzymology Vascular Calcification - genetics Vascular Calcification - pathology Vascular Calcification - prevention & control
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