Preconditioning and anti-apoptotic effects of Metformin and Cyclosporine-A in an isolated bile duct-ligated rat heart

Despite all previous studies relating to the mechanism of cirrhotic cardiomyopathy (CCM), the role of cirrhosis on Ischemic Preconditioning (IPC) has not yet been explored. The present study strives to assess the cardioprotective role of IPC in bile duct ligated (BDL) rats as well as the cardioprote...

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Veröffentlicht in:	European journal of pharmacology 2021-02, Vol.893, p.173807-173807, Article 173807
Hauptverfasser:	Moheimani, Hamid Reza, Amiriani, Taghi, Alizadeh, Ali Mohammad, Jand, Yahya, Shakiba, Delaram, Ensan, Parham Sayyah, Jafarzadeh, Fatemeh, Rajaei, Maryam, Enayati, Ayesheh, Pourabouk, Mona, Aliazadeh, Shahriar, Pourkhani, Amir Hoshang, Mazaheri, Zohreh, Zeyghami, Mohammad Ali, Dehpour, Ahmadreza, Khori, Vahid
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - metabolism Animals Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism Bile duct ligation Bile Ducts - surgery Cardiomyopathies - etiology Cardiomyopathies - metabolism Cardiomyopathies - pathology Cardiomyopathies - prevention & control Caspase Cyclosporin-A Cyclosporine - pharmacology Cytoprotection Enzyme Activation Hemodynamics - drug effects Ischemic preconditioning Ischemic Preconditioning, Myocardial Isolated Heart Preparation Ligation Liver Cirrhosis, Experimental - complications Male Metformin Metformin - pharmacology Mitochondrial Permeability Transition Pore - antagonists & inhibitors Mitochondrial Permeability Transition Pore - metabolism Myocardial Infarction - etiology Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardial Infarction - prevention & control Myocardial Reperfusion Injury - etiology Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - prevention & control Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Rats Rats, Wistar Signal Transduction
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