Effects of mammalian target of rapamycin inhibitors on fibrosis after trabeculectomy

Glaucoma, the second leading cause of blindness worldwide, is characterized by aberrant elevations of intraocular pressure (IOP), which can damage the optic nerve. IOP reduction is the only effective therapy for prevention of visual impairment and blindness in both hypertensive and normotensive indi...

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Veröffentlicht in:	Experimental eye research 2021-02, Vol.203, p.108421-108421, Article 108421
Hauptverfasser:	Igarashi, Nozomi, Honjo, Megumi, Aihara, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - genetics Actins - metabolism Animals Blotting, Western Cells, Cultured Collagen Type I - genetics Collagen Type I - metabolism Conjunctiva - metabolism Conjunctiva - pathology Fibroblasts - metabolism Fibroblasts - pathology Fibronectins - genetics Fibronectins - metabolism Fibrosis Human conjunctival fibroblasts Humans Immunohistochemistry Male mTOR Naphthyridines - pharmacology Rabbits Rapamycin Real-Time Polymerase Chain Reaction RNA, Messenger - genetics Sirolimus - pharmacology TOR Serine-Threonine Kinases - antagonists & inhibitors Torin 1 Trabeculectomy Transforming Growth Factor beta1 - pharmacology
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