Investigating the effects of the core nitrogen atom configuration on the thermodynamic solubility of 6,5-bicyclic heterocycles

[Display omitted] Physicochemical properties, such as solubility, are important when prioritising compounds for progression on a drug discovery project. There is limited literature around the systematic effects of core changes on thermodynamic solubility. This work details the synthesis of nitrogen...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2021-02, Vol.33, p.127752-127752, Article 127752
Hauptverfasser:	Cosgrove, Brett, Down, Kenneth, Bertrand, Sophie, Tomkinson, Nicholas C.O., Barker, Michael D.
Format:	Artikel
Sprache:	eng
Schlagworte:	ChromlogD7.4 Fasted State Simulated Intestinal fluid (FaSSIF) General Solubility Equation (GSE) Kinetic solubility Physicochemical properties Simulated lung fluid (SLF) Thermodynamic solubility
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