Synthesis of novel isoflavone/benzo-δ-sultam hybrids as potential anti-inflammatory drugs

[Display omitted] •A novel series of isoflavone/benzo-δ-sultam hybrids was synthesised in a straightforward manner.•The synthesised compounds were tested in LPS-activated BV2 microglia.•LPS-induced NO and TNF-α production was reduced in the presence of the synthesised compounds. A small series of no...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2021-02, Vol.34, p.127761-127761, Article 127761
Hauptverfasser:	Mengheres, Gabriel, Rice, Craig R., Olajide, Olumayokun A., Hemming, Karl
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-inflammatory Isoflavone Microglia TNF-α δ-sultam
Online-Zugang:	Volltext
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