Combined the GABA-A and GABA-B receptor agonists attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism

Autism spectrum disorder (ASD) is an immensely challenging developmental disorder characterized primarily by two core behavioral symptoms of social communication deficits and restricted/repetitive behaviors. Investigating the etiological process and identifying an appropriate therapeutic target rema...

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Veröffentlicht in:	Behavioural brain research 2021-04, Vol.403, p.113094-113094, Article 113094
Hauptverfasser:	Yang, Jian-Quan, Yang, Chao-Hua, Yin, Bao-Qi
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonist Animals Anticonvulsants - pharmacology Autism spectrum disorder Autism Spectrum Disorder - chemically induced Autism Spectrum Disorder - drug therapy Autism Spectrum Disorder - physiopathology Behavior, Animal - drug effects Disease Models, Animal Drug Therapy, Combination Female GABA-A Receptor Agonists - administration & dosage GABA-A Receptor Agonists - pharmacology GABA-B Receptor Agonists - administration & dosage GABA-B Receptor Agonists - pharmacology GABAergic neurotransmission gamma-Aminobutyric Acid - drug effects Male Mice Mice, Inbred C57BL Prefrontal Cortex - drug effects Pregnancy Prenatal Exposure Delayed Effects - chemically induced Prenatal Exposure Delayed Effects - drug therapy Prenatal Exposure Delayed Effects - physiopathology Receptor Synaptic Potentials - drug effects Synaptic Transmission - drug effects Valproic acid Valproic Acid - pharmacology
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