Ultra-early tranexamic acid after subarachnoid haemorrhage (ULTRA): a randomised controlled trial

In patients with aneurysmal subarachnoid haemorrhage, short-term antifibrinolytic therapy with tranexamic acid has been shown to reduce the risk of rebleeding. However, whether this treatment improves clinical outcome is unclear. We investigated whether ultra-early, short-term treatment with tranexa...

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Veröffentlicht in:	The Lancet (British edition) 2021-01, Vol.397 (10269), p.112-118
Hauptverfasser:	Post, René, Germans, Menno R, Tjerkstra, Maud A, Vergouwen, Mervyn D I, Jellema, Korné, Koot, Radboud W, Kruyt, Nyika D, Willems, Peter W A, Wolfs, Jasper F C, de Beer, Frits C, Kieft, Hans, Nanda, Dharmin, van der Pol, Bram, Roks, Gerwin, de Beer, Frank, Halkes, Patricia H A, Reichman, Loes J A, Brouwers, Paul J A M, van den Berg-Vos, Renske M, Kwa, Vincent I H, van der Ree, Taco C, Bronner, Irene, van de Vlekkert, Janneke, Bienfait, Henri P, Boogaarts, Hieronymus D, Klijn, Catharina J M, van den Berg, René, Coert, Bert A, Horn, Janneke, Majoie, Charles B L M, Rinkel, Gabriël J E, Roos, Yvo B W E M, Vandertop, W Peter, Verbaan, Dagmar, Germans, Menno R., Tjerkstra, Maud A., Vergouwen, Mervyn D.I., Koot, Radboud W., Kruyt, Nyika D., Willems, Peter W.A., Wolfs, Jasper F.C., de Beer, Frits C., Halkes, Patricia H.A., Reichman, Loes J.A., Brouwers, Paul J.A.M., van den Berg-Vos, Renske M., Kwa, Vincent I.H., van der Ree, Taco C., Bienfait, Henri P., Boogaarts, Hieronymus D., Klijn, Catharina J.M., van Bilzen, Martine, Dieks, H.J.G., de Gans, Koen, ten Holter, J.B.M., de Kruijk, Jelle R., Leijzer, Charlie T.J.M., Molenaar, Delmar, van Oostenbrugge, Robbert J., van Pamelen, Jeske, Spaander, Fianne H.M., Vermeer, Sarah E., Voorend, J. Manuela, Coert, Bert A., Majoie, Charles B.L.M., Rinkel, Gabriël J.E., Roos, Yvo B.W.E.M., Vandertop, W. Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Adverse events Analysis Aneurysm Aneurysms Antifibrinolytic agents Clinical outcomes Clinical trials Health services Hemorrhage Hospitals Informed consent Medical imaging Mortality Patients Pulmonary embolisms Randomization Risk reduction Statistical analysis Stroke Subarachnoid hemorrhage Thrombosis Tranexamic acid
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