Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade

Adoptive therapy using chimeric antigen receptor-modified T cells (CAR-T cells) is effective in hematologic but not epithelial malignancies, which cause the greatest mortality. In breast and lung cancer patients, CAR-T cells targeting the tumor-associated antigen receptor tyrosine kinase-like orphan...

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Veröffentlicht in:	Cancer cell 2021-02, Vol.39 (2), p.193-208.e10
Hauptverfasser:	Srivastava, Shivani, Furlan, Scott N., Jaeger-Ruckstuhl, Carla A., Sarvothama, Megha, Berger, Carolina, Smythe, Kimberly S., Garrison, Sarah M., Specht, Jennifer M., Lee, Sylvia M., Amezquita, Robert A., Voillet, Valentin, Muhunthan, Vishaka, Yechan-Gunja, Sushma, Pillai, Smitha P.S., Rader, Christoph, Houghton, A. McGarry, Pierce, Robert H., Gottardo, Raphael, Maloney, David G., Riddell, Stanley R.
Format:	Artikel
Sprache:	eng
Schlagworte:	alveolar macrophage Animals Antigens, Neoplasm - immunology CAR-T cells Cell Line Cell Line, Tumor CXCR3 CXCR6 HEK293 Cells Humans Immune Checkpoint Inhibitors - immunology immunogenic cell death Immunotherapy, Adoptive - methods lung adenocarcinoma Lung Neoplasms - immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL oxaliplatin Receptor Tyrosine Kinase-like Orphan Receptors - immunology Receptors, Antigen, T-Cell - immunology Receptors, Chimeric Antigen - immunology ROR1 T-Lymphocytes - immunology Tumor Microenvironment - immunology
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