Mouse models of atopic dermatitis: a critical reappraisal

Mouse models for atopic dermatitis (AD) are an indispensable preclinical research tool for testing new candidate AD therapeutics and for interrogating AD pathobiology in vivo. In this Viewpoint, we delineate why, unfortunately, none of the currently available so‐called “AD” mouse models satisfactori...

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Veröffentlicht in:	Experimental dermatology 2021-03, Vol.30 (3), p.319-336
Hauptverfasser:	Gilhar, Amos, Reich, Kristian, Keren, Aviad, Kabashima, Kenji, Steinhoff, Martin, Paus, Ralf
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Atopic dermatitis Biomarkers Calcitriol - analogs & derivatives CCL17 protein Chemokines Contact dermatitis Dermatitis Dermatitis, Atopic - chemically induced Dermatitis, Atopic - genetics Dermatitis, Atopic - pathology Dermatitis, Atopic - physiopathology Disease Models, Animal DNCB Filaggrin hapten Haptens humanized mouse Humans Hyperplasia Inflammation Mice Neurodermatitis Ovalbumin oxazolone Rodents Skin diseases Skin lesions Skin Physiological Phenomena Thymic stromal lymphopoietin Thymus Xenografts
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