Inflammaging and the Skin
As global life expectancy continues to rise, we are challenged with maintaining health into old age. One strategy is to target the chronic low-level inflammation associated with aging, termed inflammaging. This is characterized by increased levels of circulating proinflammatory cytokines and a shift...
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| Veröffentlicht in: | Journal of investigative dermatology 2021-04, Vol.141 (4), p.1087-1095 |
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| container_title | Journal of investigative dermatology |
| container_volume | 141 |
| creator | Pilkington, Suzanne M. Bulfone-Paus, Silvia Griffiths, Christopher E.M. Watson, Rachel E.B. |
| description | As global life expectancy continues to rise, we are challenged with maintaining health into old age. One strategy is to target the chronic low-level inflammation associated with aging, termed inflammaging. This is characterized by increased levels of circulating proinflammatory cytokines and a shift toward cellular senescence, changes that are believed to drive many age-associated conditions, including dementia, arthritis, and type 2 diabetes. As with other organs, the skin undergoes functional decline during aging, becoming more fragile and susceptible to infection; however, the contribution of inflammaging is not well-understood. This review article describes the evidence for inflammaging in the skin, its relationship with senescence, and how this relates to declining skin structure and function. |
| doi_str_mv | 10.1016/j.jid.2020.11.006 |
| format | Article |
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One strategy is to target the chronic low-level inflammation associated with aging, termed inflammaging. This is characterized by increased levels of circulating proinflammatory cytokines and a shift toward cellular senescence, changes that are believed to drive many age-associated conditions, including dementia, arthritis, and type 2 diabetes. As with other organs, the skin undergoes functional decline during aging, becoming more fragile and susceptible to infection; however, the contribution of inflammaging is not well-understood. 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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Cellular Senescence - immunology Cytokines - metabolism Fibroblasts - immunology Fibroblasts - metabolism Fibroblasts - pathology Healthy Aging - immunology Humans Immunosenescence Inflammation - immunology Keratinocytes - immunology Keratinocytes - metabolism Keratinocytes - pathology Langerhans Cells - immunology Langerhans Cells - metabolism Langerhans Cells - pathology Skin - cytology Skin - immunology Skin - metabolism Skin - pathology Skin Aging - immunology Skin Aging - pathology T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes - pathology |
| title | Inflammaging and the Skin |
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