Cobalt Bis(dicarbollide) Alkylsulfonamides: Potent and Highly Selective Inhibitors of Tumor Specific Carbonic Anhydrase IX

Invited for this month's cover is a collaboration from three institutes from the Czech Academy of Sciences: Institute of Inorganic Chemistry, Institute of Organic Chemistry and Biochemistry, and Institute of Molecular Genetics, and the University of Pardubice. The cover picture shows a family of potent and selective CA IX inhibitors that combines the structural motif of a bulky inorganic cobalt bis(dicarbollide) polyhedral ion with a propylsulfonamido anchor group. Read the full text of the article at 10.1002/cplu.202000574. “The collaboration emerged from a broader interest in the use of inorganic polyhedral boron species as inhibitors of therapeutically relevant enzymes. The mutual collaboration of chemists, biochemists, and structural biologists was very inspiring and fruitful. The most exciting facet of this research is that the three‐dimensional scaffold of the cobalt bis(dicarbollide) ion can serve as highly potent and selective inhibitors of the cancer‐specific CA IX enzyme.” Read more about the story behind the cover in the Cover Profile and about the research itself at 10.1002/cplu.2012000574.