The significance of anatomic tumor location in gallbladder cancer
Background and Objectives Current management guidelines recognize the impact of hepatic versus peritoneal sided gallbladder cancers (GBC) on survival. However, no data exist regarding the significance of anatomic tumor location within the gallbladder. Methods We retrospectively analyzed all GBC that...
Gespeichert in:
| Veröffentlicht in: | Journal of surgical oncology 2021-03, Vol.123 (4), p.932-938 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 938 |
|---|---|
| container_issue | 4 |
| container_start_page | 932 |
| container_title | Journal of surgical oncology |
| container_volume | 123 |
| creator | Leigh, Natasha Pletcher, Eric Solomon, Daniel Sarpel, Umut Labow, Daniel M. Magge, Deepa R. Golas, Benjamin J. |
| description | Background and Objectives
Current management guidelines recognize the impact of hepatic versus peritoneal sided gallbladder cancers (GBC) on survival. However, no data exist regarding the significance of anatomic tumor location within the gallbladder.
Methods
We retrospectively analyzed all GBC that underwent surgical resection with curative intent in our health system from 2007 to 2017. We evaluated the effect of anatomic pathologic tumor location (fundus/body, neck, and multifocal) on clinicopathologic, perioperative, and oncologic outcomes.
Results
About 97 patients met criteria; 63% fundus/body, 22% multifocal, and 15% neck. Compared with fundus/body, neck tumors more frequently presented with preoperative jaundice (53% vs. 13%, p |
| doi_str_mv | 10.1002/jso.26345 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_webof</sourceid><recordid>TN_cdi_proquest_miscellaneous_2473401237</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2492949045</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3535-676f46c6bbdaaaada58030f7c55a21ec7274007853dc8cdc52f126268b00d1ed3</originalsourceid><addsrcrecordid>eNqN0MtKxDAUBuAgio6XhS8gBTeKdDy5tlnK4BVhFuq6pEmqGdpGkxbx7Y0zowtBMBASyJfDz4_QIYYpBiDni-inRFDGN9AEgxS5BFluokl6IzkrJOyg3RgXACClYNtoh1IqyrQn6OLxxWbRPfeucVr12ma-yVSvBt85nQ1j50PWeq0G5_vM9dmzatu6VcbYkC192EdbjWqjPVife-jp6vJxdpPfz69vZxf3uaac8lwUomFCi7o2Ki2jeAkUmkJzrgi2uiAFAyhKTo0utdGcNJgIIsoawGBr6B46Wc19Df5ttHGoOhe1bVvVWz_GirCCMsCEFoke_6ILP4Y-pUtKEskkMJ7U6Urp4GMMtqleg-tU-KgwVF-9VqnXatlrskfriWPdWfMjv4tMoFyBd1v7JmpnUzc_LDUvUjTJSboBnrlhWejMj_2Qvp79_2vS52vtWvvxd-Tq7mG-yv4Jldig9w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2492949045</pqid></control><display><type>article</type><title>The significance of anatomic tumor location in gallbladder cancer</title><source>Access via Wiley Online Library</source><source>MEDLINE</source><source>Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><creator>Leigh, Natasha ; Pletcher, Eric ; Solomon, Daniel ; Sarpel, Umut ; Labow, Daniel M. ; Magge, Deepa R. ; Golas, Benjamin J.</creator><creatorcontrib>Leigh, Natasha ; Pletcher, Eric ; Solomon, Daniel ; Sarpel, Umut ; Labow, Daniel M. ; Magge, Deepa R. ; Golas, Benjamin J.</creatorcontrib><description>Background and Objectives
Current management guidelines recognize the impact of hepatic versus peritoneal sided gallbladder cancers (GBC) on survival. However, no data exist regarding the significance of anatomic tumor location within the gallbladder.
Methods
We retrospectively analyzed all GBC that underwent surgical resection with curative intent in our health system from 2007 to 2017. We evaluated the effect of anatomic pathologic tumor location (fundus/body, neck, and multifocal) on clinicopathologic, perioperative, and oncologic outcomes.
Results
About 97 patients met criteria; 63% fundus/body, 22% multifocal, and 15% neck. Compared with fundus/body, neck tumors more frequently presented with preoperative jaundice (53% vs. 13%, p < .001), were smaller (20 mm vs. 30 mm, p = .068) and had significantly more biliary tree invasion (33% vs. 13%, p = .030) on histopathology. Although tumor characteristics (pTNM stage, liver invasion, lymphovascular invasion, prognostic nutritional index, and grade) were similar, neck tumors had significantly higher rates of R0 resection (53% vs. 11%, p < .001). Rates of adjuvant therapy were similar. Median PFS was similar between cohorts (p = .356). However, median overall survival (OS) was significantly shorter in neck (21 months) than fundus/body tumors (NR > 109 months), p = .015.
Conclusions
Neck tumors were rare, small and more likely to result in jaundice secondary to biliary tree invasion. Despite higher R0 resection rates, these tumors had significantly worse OS.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.26345</identifier><identifier>PMID: 33368336</identifier><language>eng</language><publisher>HOBOKEN: Wiley</publisher><subject>Aged ; anatomic location ; Biliary Tract Surgical Procedures - adverse effects ; body ; Carcinoma in Situ - pathology ; Carcinoma in Situ - surgery ; Female ; Follow-Up Studies ; fundus ; Gallbladder ; Gallbladder cancer ; Gallbladder Neoplasms - pathology ; Gallbladder Neoplasms - surgery ; Hepatectomy - adverse effects ; Humans ; Jaundice - etiology ; Jaundice - pathology ; Life Sciences & Biomedicine ; Male ; Middle Aged ; neck tumor ; Oncology ; Postoperative Complications - etiology ; Postoperative Complications - pathology ; Prognosis ; Retrospective Studies ; Science & Technology ; Surgery ; Survival Rate ; Tumors</subject><ispartof>Journal of surgical oncology, 2021-03, Vol.123 (4), p.932-938</ispartof><rights>2020 Wiley Periodicals LLC</rights><rights>2020 Wiley Periodicals LLC.</rights><rights>2021 Wiley Periodicals LLC</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>5</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000601295200001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c3535-676f46c6bbdaaaada58030f7c55a21ec7274007853dc8cdc52f126268b00d1ed3</citedby><cites>FETCH-LOGICAL-c3535-676f46c6bbdaaaada58030f7c55a21ec7274007853dc8cdc52f126268b00d1ed3</cites><orcidid>0000-0002-5691-4114 ; 0000-0002-7517-0122 ; 0000-0001-9001-9431</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjso.26345$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjso.26345$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27933,27934,39267,45583,45584</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33368336$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leigh, Natasha</creatorcontrib><creatorcontrib>Pletcher, Eric</creatorcontrib><creatorcontrib>Solomon, Daniel</creatorcontrib><creatorcontrib>Sarpel, Umut</creatorcontrib><creatorcontrib>Labow, Daniel M.</creatorcontrib><creatorcontrib>Magge, Deepa R.</creatorcontrib><creatorcontrib>Golas, Benjamin J.</creatorcontrib><title>The significance of anatomic tumor location in gallbladder cancer</title><title>Journal of surgical oncology</title><addtitle>J SURG ONCOL</addtitle><addtitle>J Surg Oncol</addtitle><description>Background and Objectives
Current management guidelines recognize the impact of hepatic versus peritoneal sided gallbladder cancers (GBC) on survival. However, no data exist regarding the significance of anatomic tumor location within the gallbladder.
Methods
We retrospectively analyzed all GBC that underwent surgical resection with curative intent in our health system from 2007 to 2017. We evaluated the effect of anatomic pathologic tumor location (fundus/body, neck, and multifocal) on clinicopathologic, perioperative, and oncologic outcomes.
Results
About 97 patients met criteria; 63% fundus/body, 22% multifocal, and 15% neck. Compared with fundus/body, neck tumors more frequently presented with preoperative jaundice (53% vs. 13%, p < .001), were smaller (20 mm vs. 30 mm, p = .068) and had significantly more biliary tree invasion (33% vs. 13%, p = .030) on histopathology. Although tumor characteristics (pTNM stage, liver invasion, lymphovascular invasion, prognostic nutritional index, and grade) were similar, neck tumors had significantly higher rates of R0 resection (53% vs. 11%, p < .001). Rates of adjuvant therapy were similar. Median PFS was similar between cohorts (p = .356). However, median overall survival (OS) was significantly shorter in neck (21 months) than fundus/body tumors (NR > 109 months), p = .015.
Conclusions
Neck tumors were rare, small and more likely to result in jaundice secondary to biliary tree invasion. Despite higher R0 resection rates, these tumors had significantly worse OS.</description><subject>Aged</subject><subject>anatomic location</subject><subject>Biliary Tract Surgical Procedures - adverse effects</subject><subject>body</subject><subject>Carcinoma in Situ - pathology</subject><subject>Carcinoma in Situ - surgery</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>fundus</subject><subject>Gallbladder</subject><subject>Gallbladder cancer</subject><subject>Gallbladder Neoplasms - pathology</subject><subject>Gallbladder Neoplasms - surgery</subject><subject>Hepatectomy - adverse effects</subject><subject>Humans</subject><subject>Jaundice - etiology</subject><subject>Jaundice - pathology</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>neck tumor</subject><subject>Oncology</subject><subject>Postoperative Complications - etiology</subject><subject>Postoperative Complications - pathology</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Science & Technology</subject><subject>Surgery</subject><subject>Survival Rate</subject><subject>Tumors</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><recordid>eNqN0MtKxDAUBuAgio6XhS8gBTeKdDy5tlnK4BVhFuq6pEmqGdpGkxbx7Y0zowtBMBASyJfDz4_QIYYpBiDni-inRFDGN9AEgxS5BFluokl6IzkrJOyg3RgXACClYNtoh1IqyrQn6OLxxWbRPfeucVr12ma-yVSvBt85nQ1j50PWeq0G5_vM9dmzatu6VcbYkC192EdbjWqjPVife-jp6vJxdpPfz69vZxf3uaac8lwUomFCi7o2Ki2jeAkUmkJzrgi2uiAFAyhKTo0utdGcNJgIIsoawGBr6B46Wc19Df5ttHGoOhe1bVvVWz_GirCCMsCEFoke_6ILP4Y-pUtKEskkMJ7U6Urp4GMMtqleg-tU-KgwVF-9VqnXatlrskfriWPdWfMjv4tMoFyBd1v7JmpnUzc_LDUvUjTJSboBnrlhWejMj_2Qvp79_2vS52vtWvvxd-Tq7mG-yv4Jldig9w</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Leigh, Natasha</creator><creator>Pletcher, Eric</creator><creator>Solomon, Daniel</creator><creator>Sarpel, Umut</creator><creator>Labow, Daniel M.</creator><creator>Magge, Deepa R.</creator><creator>Golas, Benjamin J.</creator><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5691-4114</orcidid><orcidid>https://orcid.org/0000-0002-7517-0122</orcidid><orcidid>https://orcid.org/0000-0001-9001-9431</orcidid></search><sort><creationdate>20210301</creationdate><title>The significance of anatomic tumor location in gallbladder cancer</title><author>Leigh, Natasha ; Pletcher, Eric ; Solomon, Daniel ; Sarpel, Umut ; Labow, Daniel M. ; Magge, Deepa R. ; Golas, Benjamin J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3535-676f46c6bbdaaaada58030f7c55a21ec7274007853dc8cdc52f126268b00d1ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>anatomic location</topic><topic>Biliary Tract Surgical Procedures - adverse effects</topic><topic>body</topic><topic>Carcinoma in Situ - pathology</topic><topic>Carcinoma in Situ - surgery</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>fundus</topic><topic>Gallbladder</topic><topic>Gallbladder cancer</topic><topic>Gallbladder Neoplasms - pathology</topic><topic>Gallbladder Neoplasms - surgery</topic><topic>Hepatectomy - adverse effects</topic><topic>Humans</topic><topic>Jaundice - etiology</topic><topic>Jaundice - pathology</topic><topic>Life Sciences & Biomedicine</topic><topic>Male</topic><topic>Middle Aged</topic><topic>neck tumor</topic><topic>Oncology</topic><topic>Postoperative Complications - etiology</topic><topic>Postoperative Complications - pathology</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Science & Technology</topic><topic>Surgery</topic><topic>Survival Rate</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leigh, Natasha</creatorcontrib><creatorcontrib>Pletcher, Eric</creatorcontrib><creatorcontrib>Solomon, Daniel</creatorcontrib><creatorcontrib>Sarpel, Umut</creatorcontrib><creatorcontrib>Labow, Daniel M.</creatorcontrib><creatorcontrib>Magge, Deepa R.</creatorcontrib><creatorcontrib>Golas, Benjamin J.</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leigh, Natasha</au><au>Pletcher, Eric</au><au>Solomon, Daniel</au><au>Sarpel, Umut</au><au>Labow, Daniel M.</au><au>Magge, Deepa R.</au><au>Golas, Benjamin J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The significance of anatomic tumor location in gallbladder cancer</atitle><jtitle>Journal of surgical oncology</jtitle><stitle>J SURG ONCOL</stitle><addtitle>J Surg Oncol</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>123</volume><issue>4</issue><spage>932</spage><epage>938</epage><pages>932-938</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><abstract>Background and Objectives
Current management guidelines recognize the impact of hepatic versus peritoneal sided gallbladder cancers (GBC) on survival. However, no data exist regarding the significance of anatomic tumor location within the gallbladder.
Methods
We retrospectively analyzed all GBC that underwent surgical resection with curative intent in our health system from 2007 to 2017. We evaluated the effect of anatomic pathologic tumor location (fundus/body, neck, and multifocal) on clinicopathologic, perioperative, and oncologic outcomes.
Results
About 97 patients met criteria; 63% fundus/body, 22% multifocal, and 15% neck. Compared with fundus/body, neck tumors more frequently presented with preoperative jaundice (53% vs. 13%, p < .001), were smaller (20 mm vs. 30 mm, p = .068) and had significantly more biliary tree invasion (33% vs. 13%, p = .030) on histopathology. Although tumor characteristics (pTNM stage, liver invasion, lymphovascular invasion, prognostic nutritional index, and grade) were similar, neck tumors had significantly higher rates of R0 resection (53% vs. 11%, p < .001). Rates of adjuvant therapy were similar. Median PFS was similar between cohorts (p = .356). However, median overall survival (OS) was significantly shorter in neck (21 months) than fundus/body tumors (NR > 109 months), p = .015.
Conclusions
Neck tumors were rare, small and more likely to result in jaundice secondary to biliary tree invasion. Despite higher R0 resection rates, these tumors had significantly worse OS.</abstract><cop>HOBOKEN</cop><pub>Wiley</pub><pmid>33368336</pmid><doi>10.1002/jso.26345</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-5691-4114</orcidid><orcidid>https://orcid.org/0000-0002-7517-0122</orcidid><orcidid>https://orcid.org/0000-0001-9001-9431</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-4790 |
| ispartof | Journal of surgical oncology, 2021-03, Vol.123 (4), p.932-938 |
| issn | 0022-4790 1096-9098 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2473401237 |
| source | Access via Wiley Online Library; MEDLINE; Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /> |
| subjects | Aged anatomic location Biliary Tract Surgical Procedures - adverse effects body Carcinoma in Situ - pathology Carcinoma in Situ - surgery Female Follow-Up Studies fundus Gallbladder Gallbladder cancer Gallbladder Neoplasms - pathology Gallbladder Neoplasms - surgery Hepatectomy - adverse effects Humans Jaundice - etiology Jaundice - pathology Life Sciences & Biomedicine Male Middle Aged neck tumor Oncology Postoperative Complications - etiology Postoperative Complications - pathology Prognosis Retrospective Studies Science & Technology Surgery Survival Rate Tumors |
| title | The significance of anatomic tumor location in gallbladder cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-01T02%3A31%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_webof&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20significance%20of%20anatomic%20tumor%20location%20in%20gallbladder%20cancer&rft.jtitle=Journal%20of%20surgical%20oncology&rft.au=Leigh,%20Natasha&rft.date=2021-03-01&rft.volume=123&rft.issue=4&rft.spage=932&rft.epage=938&rft.pages=932-938&rft.issn=0022-4790&rft.eissn=1096-9098&rft_id=info:doi/10.1002/jso.26345&rft_dat=%3Cproquest_webof%3E2492949045%3C/proquest_webof%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2492949045&rft_id=info:pmid/33368336&rfr_iscdi=true |