Oxidative and antioxidative stress markers in keratoconus: a systematic review and meta‐analysis
Purpose To conduct a systematic review and meta‐analysis on the levels of oxidative stress markers and antioxidants in keratoconus compared to healthy subject. Method The PubMed, Cochrane Library, Embase, Science Direct and Google Scholar databases were searched on 1st June 2020 for studies reportin...
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| Veröffentlicht in: | Acta ophthalmologica (Oxford, England) England), 2021-09, Vol.99 (6), p.e777-e794 |
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| creator | Navel, Valentin Malecaze, Jean Pereira, Bruno Baker, Julien S. Malecaze, François Sapin, Vincent Chiambaretta, Frédéric Dutheil, Frédéric |
| description | Purpose
To conduct a systematic review and meta‐analysis on the levels of oxidative stress markers and antioxidants in keratoconus compared to healthy subject.
Method
The PubMed, Cochrane Library, Embase, Science Direct and Google Scholar databases were searched on 1st June 2020 for studies reporting oxidative and antioxidative stress markers in keratoconus and healthy controls. Main meta‐analysis was stratified by type of biomarkers, type of samples (tears, cornea, aqueous humour and blood) and type of corneal samples (stromal cells, epithelium and endothelium).
Results
We included 36 articles, for a total of 1328 keratoconus patients and 1208 healthy controls. There is an overall increase in oxidative stress markers in keratoconus compared with healthy controls (standard mean deviation (SMD) = 0.94, 95% confidence interval (95% CI) 0.55–1.33), with a significant increase in reactive oxygen and nitrogen species (1.09, 0.41–1.78) and malondialdehyde (1.78, 0.83–2.73). There is an overall decrease in antioxidants in keratoconus compared with healthy controls (−0.63, −0.89 to −0.36), with a significant decrease in total antioxidant capacity/status (−1.65, −2.88 to −0.43), aldehyde/NADPH dehydrogenase (−0.77, −1.38 to −0.17), lactoferrin/transferrin/albumin (−1.92, −2.96 to −0.89) and selenium/zinc (−1.42, −2.23 to −0.61). Oxidative stress markers were higher in tears and in cornea of keratoconus than in aqueous humour, and antioxidants were decreased in tears, aqueous humour and blood without difference between sample type. Oxidative stress markers increased in stromal cells and antioxidants decreased in endothelium.
Conclusion
Oxidative stress markers and antioxidants were dysregulated in keratoconus, involving an imbalance of redox homeostasis in tears, cornea, aqueous humour and blood. |
| doi_str_mv | 10.1111/aos.14714 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_proquest_miscellaneous_2473400928</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2473400928</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4224-df2324e5f8267554f24814045b6e31db6bf30fafbc775fc8f5d4d857bf2fea843</originalsourceid><addsrcrecordid>eNp1kdtKHEEQhpugxENykRcIA97oxWqfezZ3i8QDLOxFEshd0zNTja0z06ZrZs3e-Qg-o09i6-oKgRQU1RQff_3NT8gXRo9ZrhMX8ZhJw-QHssuMUhNhdLm1eavfO2QP8ZpSzbSWH8mOEELJKTe7pFr8DY0bwhIK1ze5hxA3GxwSIBadSzeQsAh9kacbYh37Eb8VrsAVDtBluC4SLAPcvYh0MLjH-wfXu3aFAT-Rbe9ahM-vc5_8Ovv-8_RiMl-cX57O5pNaci4njeeCS1C-5Dr7lp7LkkkqVaVBsKbSlRfUO1_Vxihfl141simVqTz34Eop9snRWvfKtfY2hWx7ZaML9mI2t887KiQVU6qWLLOHa_Y2xT8j4GC7gDW0reshjmi5NBmmU15m9OAf9DqOKf8tU8owzaai1O_H6xQRE_iNA0btc0g2h2RfQsrs11fFseqg2ZBvqWTgZA3chRZW_1eys8WPteQT-QGcag</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2571619386</pqid></control><display><type>article</type><title>Oxidative and antioxidative stress markers in keratoconus: a systematic review and meta‐analysis</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Navel, Valentin ; Malecaze, Jean ; Pereira, Bruno ; Baker, Julien S. ; Malecaze, François ; Sapin, Vincent ; Chiambaretta, Frédéric ; Dutheil, Frédéric</creator><creatorcontrib>Navel, Valentin ; Malecaze, Jean ; Pereira, Bruno ; Baker, Julien S. ; Malecaze, François ; Sapin, Vincent ; Chiambaretta, Frédéric ; Dutheil, Frédéric</creatorcontrib><description>Purpose
To conduct a systematic review and meta‐analysis on the levels of oxidative stress markers and antioxidants in keratoconus compared to healthy subject.
Method
The PubMed, Cochrane Library, Embase, Science Direct and Google Scholar databases were searched on 1st June 2020 for studies reporting oxidative and antioxidative stress markers in keratoconus and healthy controls. Main meta‐analysis was stratified by type of biomarkers, type of samples (tears, cornea, aqueous humour and blood) and type of corneal samples (stromal cells, epithelium and endothelium).
Results
We included 36 articles, for a total of 1328 keratoconus patients and 1208 healthy controls. There is an overall increase in oxidative stress markers in keratoconus compared with healthy controls (standard mean deviation (SMD) = 0.94, 95% confidence interval (95% CI) 0.55–1.33), with a significant increase in reactive oxygen and nitrogen species (1.09, 0.41–1.78) and malondialdehyde (1.78, 0.83–2.73). There is an overall decrease in antioxidants in keratoconus compared with healthy controls (−0.63, −0.89 to −0.36), with a significant decrease in total antioxidant capacity/status (−1.65, −2.88 to −0.43), aldehyde/NADPH dehydrogenase (−0.77, −1.38 to −0.17), lactoferrin/transferrin/albumin (−1.92, −2.96 to −0.89) and selenium/zinc (−1.42, −2.23 to −0.61). Oxidative stress markers were higher in tears and in cornea of keratoconus than in aqueous humour, and antioxidants were decreased in tears, aqueous humour and blood without difference between sample type. Oxidative stress markers increased in stromal cells and antioxidants decreased in endothelium.
Conclusion
Oxidative stress markers and antioxidants were dysregulated in keratoconus, involving an imbalance of redox homeostasis in tears, cornea, aqueous humour and blood.</description><identifier>ISSN: 1755-375X</identifier><identifier>ISSN: 1395-3931</identifier><identifier>EISSN: 1755-3768</identifier><identifier>DOI: 10.1111/aos.14714</identifier><identifier>PMID: 33354927</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Antioxidants ; Antioxidants - metabolism ; Aqueous Humor - metabolism ; Biomarkers - metabolism ; Blood ; Cornea ; Cornea - metabolism ; Endothelium ; Epithelium ; Homeostasis ; Human health and pathology ; Humanities and Social Sciences ; Humans ; inflammation ; Keratoconus ; Keratoconus - metabolism ; Lactoferrin ; Life Sciences ; Malondialdehyde ; Meta-analysis ; NADPH dehydrogenase ; oxidative damage ; Oxidative Stress ; Psychology ; Reactive nitrogen species ; Reactive oxygen species ; Selenium ; Sensory Organs ; stroma ; Stromal cells ; Systematic review ; Tears ; Tears - metabolism ; Transferrins</subject><ispartof>Acta ophthalmologica (Oxford, England), 2021-09, Vol.99 (6), p.e777-e794</ispartof><rights>2020 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd</rights><rights>2020 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2021 Acta Ophthalmologica Scandinavica Foundation</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4224-df2324e5f8267554f24814045b6e31db6bf30fafbc775fc8f5d4d857bf2fea843</citedby><cites>FETCH-LOGICAL-c4224-df2324e5f8267554f24814045b6e31db6bf30fafbc775fc8f5d4d857bf2fea843</cites><orcidid>0000-0002-1468-6029 ; 0000-0001-6317-345X ; 0000-0002-9093-7897 ; 0000-0002-7452-315X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Faos.14714$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Faos.14714$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,881,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33354927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03403905$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Navel, Valentin</creatorcontrib><creatorcontrib>Malecaze, Jean</creatorcontrib><creatorcontrib>Pereira, Bruno</creatorcontrib><creatorcontrib>Baker, Julien S.</creatorcontrib><creatorcontrib>Malecaze, François</creatorcontrib><creatorcontrib>Sapin, Vincent</creatorcontrib><creatorcontrib>Chiambaretta, Frédéric</creatorcontrib><creatorcontrib>Dutheil, Frédéric</creatorcontrib><title>Oxidative and antioxidative stress markers in keratoconus: a systematic review and meta‐analysis</title><title>Acta ophthalmologica (Oxford, England)</title><addtitle>Acta Ophthalmol</addtitle><description>Purpose
To conduct a systematic review and meta‐analysis on the levels of oxidative stress markers and antioxidants in keratoconus compared to healthy subject.
Method
The PubMed, Cochrane Library, Embase, Science Direct and Google Scholar databases were searched on 1st June 2020 for studies reporting oxidative and antioxidative stress markers in keratoconus and healthy controls. Main meta‐analysis was stratified by type of biomarkers, type of samples (tears, cornea, aqueous humour and blood) and type of corneal samples (stromal cells, epithelium and endothelium).
Results
We included 36 articles, for a total of 1328 keratoconus patients and 1208 healthy controls. There is an overall increase in oxidative stress markers in keratoconus compared with healthy controls (standard mean deviation (SMD) = 0.94, 95% confidence interval (95% CI) 0.55–1.33), with a significant increase in reactive oxygen and nitrogen species (1.09, 0.41–1.78) and malondialdehyde (1.78, 0.83–2.73). There is an overall decrease in antioxidants in keratoconus compared with healthy controls (−0.63, −0.89 to −0.36), with a significant decrease in total antioxidant capacity/status (−1.65, −2.88 to −0.43), aldehyde/NADPH dehydrogenase (−0.77, −1.38 to −0.17), lactoferrin/transferrin/albumin (−1.92, −2.96 to −0.89) and selenium/zinc (−1.42, −2.23 to −0.61). Oxidative stress markers were higher in tears and in cornea of keratoconus than in aqueous humour, and antioxidants were decreased in tears, aqueous humour and blood without difference between sample type. Oxidative stress markers increased in stromal cells and antioxidants decreased in endothelium.
Conclusion
Oxidative stress markers and antioxidants were dysregulated in keratoconus, involving an imbalance of redox homeostasis in tears, cornea, aqueous humour and blood.</description><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Aqueous Humor - metabolism</subject><subject>Biomarkers - metabolism</subject><subject>Blood</subject><subject>Cornea</subject><subject>Cornea - metabolism</subject><subject>Endothelium</subject><subject>Epithelium</subject><subject>Homeostasis</subject><subject>Human health and pathology</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>inflammation</subject><subject>Keratoconus</subject><subject>Keratoconus - metabolism</subject><subject>Lactoferrin</subject><subject>Life Sciences</subject><subject>Malondialdehyde</subject><subject>Meta-analysis</subject><subject>NADPH dehydrogenase</subject><subject>oxidative damage</subject><subject>Oxidative Stress</subject><subject>Psychology</subject><subject>Reactive nitrogen species</subject><subject>Reactive oxygen species</subject><subject>Selenium</subject><subject>Sensory Organs</subject><subject>stroma</subject><subject>Stromal cells</subject><subject>Systematic review</subject><subject>Tears</subject><subject>Tears - metabolism</subject><subject>Transferrins</subject><issn>1755-375X</issn><issn>1395-3931</issn><issn>1755-3768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kdtKHEEQhpugxENykRcIA97oxWqfezZ3i8QDLOxFEshd0zNTja0z06ZrZs3e-Qg-o09i6-oKgRQU1RQff_3NT8gXRo9ZrhMX8ZhJw-QHssuMUhNhdLm1eavfO2QP8ZpSzbSWH8mOEELJKTe7pFr8DY0bwhIK1ze5hxA3GxwSIBadSzeQsAh9kacbYh37Eb8VrsAVDtBluC4SLAPcvYh0MLjH-wfXu3aFAT-Rbe9ahM-vc5_8Ovv-8_RiMl-cX57O5pNaci4njeeCS1C-5Dr7lp7LkkkqVaVBsKbSlRfUO1_Vxihfl141simVqTz34Eop9snRWvfKtfY2hWx7ZaML9mI2t887KiQVU6qWLLOHa_Y2xT8j4GC7gDW0reshjmi5NBmmU15m9OAf9DqOKf8tU8owzaai1O_H6xQRE_iNA0btc0g2h2RfQsrs11fFseqg2ZBvqWTgZA3chRZW_1eys8WPteQT-QGcag</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Navel, Valentin</creator><creator>Malecaze, Jean</creator><creator>Pereira, Bruno</creator><creator>Baker, Julien S.</creator><creator>Malecaze, François</creator><creator>Sapin, Vincent</creator><creator>Chiambaretta, Frédéric</creator><creator>Dutheil, Frédéric</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>1XC</scope><scope>BXJBU</scope><orcidid>https://orcid.org/0000-0002-1468-6029</orcidid><orcidid>https://orcid.org/0000-0001-6317-345X</orcidid><orcidid>https://orcid.org/0000-0002-9093-7897</orcidid><orcidid>https://orcid.org/0000-0002-7452-315X</orcidid></search><sort><creationdate>202109</creationdate><title>Oxidative and antioxidative stress markers in keratoconus: a systematic review and meta‐analysis</title><author>Navel, Valentin ; Malecaze, Jean ; Pereira, Bruno ; Baker, Julien S. ; Malecaze, François ; Sapin, Vincent ; Chiambaretta, Frédéric ; Dutheil, Frédéric</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4224-df2324e5f8267554f24814045b6e31db6bf30fafbc775fc8f5d4d857bf2fea843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Aqueous Humor - metabolism</topic><topic>Biomarkers - metabolism</topic><topic>Blood</topic><topic>Cornea</topic><topic>Cornea - metabolism</topic><topic>Endothelium</topic><topic>Epithelium</topic><topic>Homeostasis</topic><topic>Human health and pathology</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>inflammation</topic><topic>Keratoconus</topic><topic>Keratoconus - metabolism</topic><topic>Lactoferrin</topic><topic>Life Sciences</topic><topic>Malondialdehyde</topic><topic>Meta-analysis</topic><topic>NADPH dehydrogenase</topic><topic>oxidative damage</topic><topic>Oxidative Stress</topic><topic>Psychology</topic><topic>Reactive nitrogen species</topic><topic>Reactive oxygen species</topic><topic>Selenium</topic><topic>Sensory Organs</topic><topic>stroma</topic><topic>Stromal cells</topic><topic>Systematic review</topic><topic>Tears</topic><topic>Tears - metabolism</topic><topic>Transferrins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Navel, Valentin</creatorcontrib><creatorcontrib>Malecaze, Jean</creatorcontrib><creatorcontrib>Pereira, Bruno</creatorcontrib><creatorcontrib>Baker, Julien S.</creatorcontrib><creatorcontrib>Malecaze, François</creatorcontrib><creatorcontrib>Sapin, Vincent</creatorcontrib><creatorcontrib>Chiambaretta, Frédéric</creatorcontrib><creatorcontrib>Dutheil, Frédéric</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>HAL-SHS: Archive ouverte en Sciences de l'Homme et de la Société</collection><jtitle>Acta ophthalmologica (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Navel, Valentin</au><au>Malecaze, Jean</au><au>Pereira, Bruno</au><au>Baker, Julien S.</au><au>Malecaze, François</au><au>Sapin, Vincent</au><au>Chiambaretta, Frédéric</au><au>Dutheil, Frédéric</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxidative and antioxidative stress markers in keratoconus: a systematic review and meta‐analysis</atitle><jtitle>Acta ophthalmologica (Oxford, England)</jtitle><addtitle>Acta Ophthalmol</addtitle><date>2021-09</date><risdate>2021</risdate><volume>99</volume><issue>6</issue><spage>e777</spage><epage>e794</epage><pages>e777-e794</pages><issn>1755-375X</issn><issn>1395-3931</issn><eissn>1755-3768</eissn><abstract>Purpose
To conduct a systematic review and meta‐analysis on the levels of oxidative stress markers and antioxidants in keratoconus compared to healthy subject.
Method
The PubMed, Cochrane Library, Embase, Science Direct and Google Scholar databases were searched on 1st June 2020 for studies reporting oxidative and antioxidative stress markers in keratoconus and healthy controls. Main meta‐analysis was stratified by type of biomarkers, type of samples (tears, cornea, aqueous humour and blood) and type of corneal samples (stromal cells, epithelium and endothelium).
Results
We included 36 articles, for a total of 1328 keratoconus patients and 1208 healthy controls. There is an overall increase in oxidative stress markers in keratoconus compared with healthy controls (standard mean deviation (SMD) = 0.94, 95% confidence interval (95% CI) 0.55–1.33), with a significant increase in reactive oxygen and nitrogen species (1.09, 0.41–1.78) and malondialdehyde (1.78, 0.83–2.73). There is an overall decrease in antioxidants in keratoconus compared with healthy controls (−0.63, −0.89 to −0.36), with a significant decrease in total antioxidant capacity/status (−1.65, −2.88 to −0.43), aldehyde/NADPH dehydrogenase (−0.77, −1.38 to −0.17), lactoferrin/transferrin/albumin (−1.92, −2.96 to −0.89) and selenium/zinc (−1.42, −2.23 to −0.61). Oxidative stress markers were higher in tears and in cornea of keratoconus than in aqueous humour, and antioxidants were decreased in tears, aqueous humour and blood without difference between sample type. Oxidative stress markers increased in stromal cells and antioxidants decreased in endothelium.
Conclusion
Oxidative stress markers and antioxidants were dysregulated in keratoconus, involving an imbalance of redox homeostasis in tears, cornea, aqueous humour and blood.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33354927</pmid><doi>10.1111/aos.14714</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0002-1468-6029</orcidid><orcidid>https://orcid.org/0000-0001-6317-345X</orcidid><orcidid>https://orcid.org/0000-0002-9093-7897</orcidid><orcidid>https://orcid.org/0000-0002-7452-315X</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1755-375X |
| ispartof | Acta ophthalmologica (Oxford, England), 2021-09, Vol.99 (6), p.e777-e794 |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Antioxidants Antioxidants - metabolism Aqueous Humor - metabolism Biomarkers - metabolism Blood Cornea Cornea - metabolism Endothelium Epithelium Homeostasis Human health and pathology Humanities and Social Sciences Humans inflammation Keratoconus Keratoconus - metabolism Lactoferrin Life Sciences Malondialdehyde Meta-analysis NADPH dehydrogenase oxidative damage Oxidative Stress Psychology Reactive nitrogen species Reactive oxygen species Selenium Sensory Organs stroma Stromal cells Systematic review Tears Tears - metabolism Transferrins |
| title | Oxidative and antioxidative stress markers in keratoconus: a systematic review and meta‐analysis |
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