Low circulating dihomo-gamma-linolenic acid is associated with diabetic retinopathy: a cross sectional study of KAMOGAWA-DM cohort study
Diabetic retinopathy (DR), one of the major complications of diabetes, can cause blindness and reduce quality of life. Dyslipidemia is reported to be associated with DR, whereas arachidonic acid may have a protective effect against DR. We aimed to investigate the association of circulating n-3 and n...
Gespeichert in:
| Veröffentlicht in: | Endocrine Journal 2021, Vol.68(4), pp.421-428 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 428 |
|---|---|
| container_issue | 4 |
| container_start_page | 421 |
| container_title | Endocrine Journal |
| container_volume | 68 |
| creator | Okamura, Takuro Nakajima, Hanako Hashimoto, Yoshitaka Majima, Saori Senmaru, Takafumi Ushigome, Emi Nakanishi, Naoko Hamaguchi, Masahide Asano, Mai Yamazaki, Masahiro Takakuwa, Hiroshi Fukui, Michiaki |
| description | Diabetic retinopathy (DR), one of the major complications of diabetes, can cause blindness and reduce quality of life. Dyslipidemia is reported to be associated with DR, whereas arachidonic acid may have a protective effect against DR. We aimed to investigate the association of circulating n-3 and n-6 polyunsaturated fatty acids (PUFAs) with DR. In this cross-sectional study, 190 Japanese patients with type 2 diabetes were classified as no diabetic retinopathy (NDR), simple diabetic retinopathy (SDR), or proliferative diabetic retinopathy (PDR) including pre-proliferative diabetic retinopathy. Circulating fatty acids (FAs) were measured by gas chromatograph-mass spectrometry. Logistic regression analysis was performed to investigate the association between the levels of FAs and the presence of DR. The average age, body mass index and the duration of diabetes were 62.7 ± 12.1 years, 25.0 ± 4.5 kg/m2, and 9.8 ± 8.7 years, respectively. Twenty-seven patients were diagnosed with DR. Circulating levels of dihomo-gamma-linolenic acid (DGLA) in the NDR (n = 163), SDR (n = 13) and PDR (n = 14) groups were 28.3 ± 11.0 μg/mL, 24.4 ± 9.7 μg/mL, and 21.8 ± 6.2 μg/mL, respectively (p = 0.032). The logarithm of circulating DGLA levels was associated with the presence of DR after adjusting for covariates (OR of 1-unit increment: 0.79, 95% CI: 0.62–1.00, p = 0.049). Circulating DGLA was negatively associated with the presence of DR. |
| doi_str_mv | 10.1507/endocrj.EJ20-0564 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2473399341</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2473399341</sourcerecordid><originalsourceid>FETCH-LOGICAL-c526t-1090d67e679569c81f31bdd195fcd4ecf9b1132558f7f11a8cf85f9cfc6af1343</originalsourceid><addsrcrecordid>eNpdkc1uEzEUhS1ERUPLA7BBltiwcbHH9syYXVRKgKbqpoil5fgn42hmHGyPqrwBj41DwizY3Lu43znSPQeAtwTfEI6bj3Y0Qcfdzd33CiPMa_YCLAhlLWKc4ZdggQVpUSu4uASvU9phTCln9BW4pJTWpBbVAvxeh2eofdRTr7Ift9D4LgwBbdUwKNT7MfR29Boq7Q30CaqUgvYqWwOffe4KrjY2FyCWOYa9yt3hE1RQx5ASTFZnH0bVw5Qnc4DBwfvlw-Nq-XOJPj9AHboQ8-l2DS6c6pN9c95X4MeXu6fbr2j9uPp2u1wjzas6I4IFNnVj60bwWuiWOEo2xhDBnTbMaic2hNCK89Y1jhDVatdyJ7TTtXIlG3oFPpx89zH8mmzKcvBJ275Xow1TkhVrKBWCMlLQ9_-huzDF8k2heIVLlGUVipyovy9H6-Q--kHFgyRYHmuS55rksSZ5rKlo3p2dp81gzaz410sBVidgl7La2hlQsWTd29mybiU7jtl6JnSnYsHoH6npqrU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2520543252</pqid></control><display><type>article</type><title>Low circulating dihomo-gamma-linolenic acid is associated with diabetic retinopathy: a cross sectional study of KAMOGAWA-DM cohort study</title><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Okamura, Takuro ; Nakajima, Hanako ; Hashimoto, Yoshitaka ; Majima, Saori ; Senmaru, Takafumi ; Ushigome, Emi ; Nakanishi, Naoko ; Hamaguchi, Masahide ; Asano, Mai ; Yamazaki, Masahiro ; Takakuwa, Hiroshi ; Fukui, Michiaki</creator><creatorcontrib>Okamura, Takuro ; Nakajima, Hanako ; Hashimoto, Yoshitaka ; Majima, Saori ; Senmaru, Takafumi ; Ushigome, Emi ; Nakanishi, Naoko ; Hamaguchi, Masahide ; Asano, Mai ; Yamazaki, Masahiro ; Takakuwa, Hiroshi ; Fukui, Michiaki</creatorcontrib><description>Diabetic retinopathy (DR), one of the major complications of diabetes, can cause blindness and reduce quality of life. Dyslipidemia is reported to be associated with DR, whereas arachidonic acid may have a protective effect against DR. We aimed to investigate the association of circulating n-3 and n-6 polyunsaturated fatty acids (PUFAs) with DR. In this cross-sectional study, 190 Japanese patients with type 2 diabetes were classified as no diabetic retinopathy (NDR), simple diabetic retinopathy (SDR), or proliferative diabetic retinopathy (PDR) including pre-proliferative diabetic retinopathy. Circulating fatty acids (FAs) were measured by gas chromatograph-mass spectrometry. Logistic regression analysis was performed to investigate the association between the levels of FAs and the presence of DR. The average age, body mass index and the duration of diabetes were 62.7 ± 12.1 years, 25.0 ± 4.5 kg/m2, and 9.8 ± 8.7 years, respectively. Twenty-seven patients were diagnosed with DR. Circulating levels of dihomo-gamma-linolenic acid (DGLA) in the NDR (n = 163), SDR (n = 13) and PDR (n = 14) groups were 28.3 ± 11.0 μg/mL, 24.4 ± 9.7 μg/mL, and 21.8 ± 6.2 μg/mL, respectively (p = 0.032). The logarithm of circulating DGLA levels was associated with the presence of DR after adjusting for covariates (OR of 1-unit increment: 0.79, 95% CI: 0.62–1.00, p = 0.049). Circulating DGLA was negatively associated with the presence of DR.</description><identifier>ISSN: 0918-8959</identifier><identifier>EISSN: 1348-4540</identifier><identifier>DOI: 10.1507/endocrj.EJ20-0564</identifier><identifier>PMID: 33361692</identifier><language>eng</language><publisher>Japan: The Japan Endocrine Society</publisher><subject>Arachidonic acid ; Blindness ; Body mass index ; Cohort analysis ; Cohort study ; Cross-sectional studies ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; Diabetic retinopathy ; Dihomo-gamma-linolenic acid ; Dyslipidemia ; Epidemiology ; Fatty acids ; Linolenic acid ; Mass spectroscopy ; Polyunsaturated fatty acids ; Quality of life ; Retinopathy</subject><ispartof>Endocrine Journal, 2021, Vol.68(4), pp.421-428</ispartof><rights>The Japan Endocrine Society</rights><rights>Copyright Japan Science and Technology Agency 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-1090d67e679569c81f31bdd195fcd4ecf9b1132558f7f11a8cf85f9cfc6af1343</citedby><cites>FETCH-LOGICAL-c526t-1090d67e679569c81f31bdd195fcd4ecf9b1132558f7f11a8cf85f9cfc6af1343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33361692$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okamura, Takuro</creatorcontrib><creatorcontrib>Nakajima, Hanako</creatorcontrib><creatorcontrib>Hashimoto, Yoshitaka</creatorcontrib><creatorcontrib>Majima, Saori</creatorcontrib><creatorcontrib>Senmaru, Takafumi</creatorcontrib><creatorcontrib>Ushigome, Emi</creatorcontrib><creatorcontrib>Nakanishi, Naoko</creatorcontrib><creatorcontrib>Hamaguchi, Masahide</creatorcontrib><creatorcontrib>Asano, Mai</creatorcontrib><creatorcontrib>Yamazaki, Masahiro</creatorcontrib><creatorcontrib>Takakuwa, Hiroshi</creatorcontrib><creatorcontrib>Fukui, Michiaki</creatorcontrib><title>Low circulating dihomo-gamma-linolenic acid is associated with diabetic retinopathy: a cross sectional study of KAMOGAWA-DM cohort study</title><title>Endocrine Journal</title><addtitle>Endocr J</addtitle><description>Diabetic retinopathy (DR), one of the major complications of diabetes, can cause blindness and reduce quality of life. Dyslipidemia is reported to be associated with DR, whereas arachidonic acid may have a protective effect against DR. We aimed to investigate the association of circulating n-3 and n-6 polyunsaturated fatty acids (PUFAs) with DR. In this cross-sectional study, 190 Japanese patients with type 2 diabetes were classified as no diabetic retinopathy (NDR), simple diabetic retinopathy (SDR), or proliferative diabetic retinopathy (PDR) including pre-proliferative diabetic retinopathy. Circulating fatty acids (FAs) were measured by gas chromatograph-mass spectrometry. Logistic regression analysis was performed to investigate the association between the levels of FAs and the presence of DR. The average age, body mass index and the duration of diabetes were 62.7 ± 12.1 years, 25.0 ± 4.5 kg/m2, and 9.8 ± 8.7 years, respectively. Twenty-seven patients were diagnosed with DR. Circulating levels of dihomo-gamma-linolenic acid (DGLA) in the NDR (n = 163), SDR (n = 13) and PDR (n = 14) groups were 28.3 ± 11.0 μg/mL, 24.4 ± 9.7 μg/mL, and 21.8 ± 6.2 μg/mL, respectively (p = 0.032). The logarithm of circulating DGLA levels was associated with the presence of DR after adjusting for covariates (OR of 1-unit increment: 0.79, 95% CI: 0.62–1.00, p = 0.049). Circulating DGLA was negatively associated with the presence of DR.</description><subject>Arachidonic acid</subject><subject>Blindness</subject><subject>Body mass index</subject><subject>Cohort analysis</subject><subject>Cohort study</subject><subject>Cross-sectional studies</subject><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetic retinopathy</subject><subject>Dihomo-gamma-linolenic acid</subject><subject>Dyslipidemia</subject><subject>Epidemiology</subject><subject>Fatty acids</subject><subject>Linolenic acid</subject><subject>Mass spectroscopy</subject><subject>Polyunsaturated fatty acids</subject><subject>Quality of life</subject><subject>Retinopathy</subject><issn>0918-8959</issn><issn>1348-4540</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpdkc1uEzEUhS1ERUPLA7BBltiwcbHH9syYXVRKgKbqpoil5fgn42hmHGyPqrwBj41DwizY3Lu43znSPQeAtwTfEI6bj3Y0Qcfdzd33CiPMa_YCLAhlLWKc4ZdggQVpUSu4uASvU9phTCln9BW4pJTWpBbVAvxeh2eofdRTr7Ift9D4LgwBbdUwKNT7MfR29Boq7Q30CaqUgvYqWwOffe4KrjY2FyCWOYa9yt3hE1RQx5ASTFZnH0bVw5Qnc4DBwfvlw-Nq-XOJPj9AHboQ8-l2DS6c6pN9c95X4MeXu6fbr2j9uPp2u1wjzas6I4IFNnVj60bwWuiWOEo2xhDBnTbMaic2hNCK89Y1jhDVatdyJ7TTtXIlG3oFPpx89zH8mmzKcvBJ275Xow1TkhVrKBWCMlLQ9_-huzDF8k2heIVLlGUVipyovy9H6-Q--kHFgyRYHmuS55rksSZ5rKlo3p2dp81gzaz410sBVidgl7La2hlQsWTd29mybiU7jtl6JnSnYsHoH6npqrU</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Okamura, Takuro</creator><creator>Nakajima, Hanako</creator><creator>Hashimoto, Yoshitaka</creator><creator>Majima, Saori</creator><creator>Senmaru, Takafumi</creator><creator>Ushigome, Emi</creator><creator>Nakanishi, Naoko</creator><creator>Hamaguchi, Masahide</creator><creator>Asano, Mai</creator><creator>Yamazaki, Masahiro</creator><creator>Takakuwa, Hiroshi</creator><creator>Fukui, Michiaki</creator><general>The Japan Endocrine Society</general><general>Japan Science and Technology Agency</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20210101</creationdate><title>Low circulating dihomo-gamma-linolenic acid is associated with diabetic retinopathy: a cross sectional study of KAMOGAWA-DM cohort study</title><author>Okamura, Takuro ; Nakajima, Hanako ; Hashimoto, Yoshitaka ; Majima, Saori ; Senmaru, Takafumi ; Ushigome, Emi ; Nakanishi, Naoko ; Hamaguchi, Masahide ; Asano, Mai ; Yamazaki, Masahiro ; Takakuwa, Hiroshi ; Fukui, Michiaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-1090d67e679569c81f31bdd195fcd4ecf9b1132558f7f11a8cf85f9cfc6af1343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Arachidonic acid</topic><topic>Blindness</topic><topic>Body mass index</topic><topic>Cohort analysis</topic><topic>Cohort study</topic><topic>Cross-sectional studies</topic><topic>Diabetes</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetic retinopathy</topic><topic>Dihomo-gamma-linolenic acid</topic><topic>Dyslipidemia</topic><topic>Epidemiology</topic><topic>Fatty acids</topic><topic>Linolenic acid</topic><topic>Mass spectroscopy</topic><topic>Polyunsaturated fatty acids</topic><topic>Quality of life</topic><topic>Retinopathy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okamura, Takuro</creatorcontrib><creatorcontrib>Nakajima, Hanako</creatorcontrib><creatorcontrib>Hashimoto, Yoshitaka</creatorcontrib><creatorcontrib>Majima, Saori</creatorcontrib><creatorcontrib>Senmaru, Takafumi</creatorcontrib><creatorcontrib>Ushigome, Emi</creatorcontrib><creatorcontrib>Nakanishi, Naoko</creatorcontrib><creatorcontrib>Hamaguchi, Masahide</creatorcontrib><creatorcontrib>Asano, Mai</creatorcontrib><creatorcontrib>Yamazaki, Masahiro</creatorcontrib><creatorcontrib>Takakuwa, Hiroshi</creatorcontrib><creatorcontrib>Fukui, Michiaki</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrine Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okamura, Takuro</au><au>Nakajima, Hanako</au><au>Hashimoto, Yoshitaka</au><au>Majima, Saori</au><au>Senmaru, Takafumi</au><au>Ushigome, Emi</au><au>Nakanishi, Naoko</au><au>Hamaguchi, Masahide</au><au>Asano, Mai</au><au>Yamazaki, Masahiro</au><au>Takakuwa, Hiroshi</au><au>Fukui, Michiaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low circulating dihomo-gamma-linolenic acid is associated with diabetic retinopathy: a cross sectional study of KAMOGAWA-DM cohort study</atitle><jtitle>Endocrine Journal</jtitle><addtitle>Endocr J</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>68</volume><issue>4</issue><spage>421</spage><epage>428</epage><pages>421-428</pages><issn>0918-8959</issn><eissn>1348-4540</eissn><abstract>Diabetic retinopathy (DR), one of the major complications of diabetes, can cause blindness and reduce quality of life. Dyslipidemia is reported to be associated with DR, whereas arachidonic acid may have a protective effect against DR. We aimed to investigate the association of circulating n-3 and n-6 polyunsaturated fatty acids (PUFAs) with DR. In this cross-sectional study, 190 Japanese patients with type 2 diabetes were classified as no diabetic retinopathy (NDR), simple diabetic retinopathy (SDR), or proliferative diabetic retinopathy (PDR) including pre-proliferative diabetic retinopathy. Circulating fatty acids (FAs) were measured by gas chromatograph-mass spectrometry. Logistic regression analysis was performed to investigate the association between the levels of FAs and the presence of DR. The average age, body mass index and the duration of diabetes were 62.7 ± 12.1 years, 25.0 ± 4.5 kg/m2, and 9.8 ± 8.7 years, respectively. Twenty-seven patients were diagnosed with DR. Circulating levels of dihomo-gamma-linolenic acid (DGLA) in the NDR (n = 163), SDR (n = 13) and PDR (n = 14) groups were 28.3 ± 11.0 μg/mL, 24.4 ± 9.7 μg/mL, and 21.8 ± 6.2 μg/mL, respectively (p = 0.032). The logarithm of circulating DGLA levels was associated with the presence of DR after adjusting for covariates (OR of 1-unit increment: 0.79, 95% CI: 0.62–1.00, p = 0.049). Circulating DGLA was negatively associated with the presence of DR.</abstract><cop>Japan</cop><pub>The Japan Endocrine Society</pub><pmid>33361692</pmid><doi>10.1507/endocrj.EJ20-0564</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0918-8959 |
| ispartof | Endocrine Journal, 2021, Vol.68(4), pp.421-428 |
| issn | 0918-8959 1348-4540 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2473399341 |
| source | J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Arachidonic acid Blindness Body mass index Cohort analysis Cohort study Cross-sectional studies Diabetes Diabetes mellitus (non-insulin dependent) Diabetic retinopathy Dihomo-gamma-linolenic acid Dyslipidemia Epidemiology Fatty acids Linolenic acid Mass spectroscopy Polyunsaturated fatty acids Quality of life Retinopathy |
| title | Low circulating dihomo-gamma-linolenic acid is associated with diabetic retinopathy: a cross sectional study of KAMOGAWA-DM cohort study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T01%3A40%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Low%20circulating%20dihomo-gamma-linolenic%20acid%20is%20associated%20with%20diabetic%20retinopathy:%20a%20cross%20sectional%20study%20of%20KAMOGAWA-DM%20cohort%20study&rft.jtitle=Endocrine%20Journal&rft.au=Okamura,%20Takuro&rft.date=2021-01-01&rft.volume=68&rft.issue=4&rft.spage=421&rft.epage=428&rft.pages=421-428&rft.issn=0918-8959&rft.eissn=1348-4540&rft_id=info:doi/10.1507/endocrj.EJ20-0564&rft_dat=%3Cproquest_cross%3E2473399341%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2520543252&rft_id=info:pmid/33361692&rfr_iscdi=true |