Knockdown of slit signaling during limb development leads to a reduction in humerus length

Background Slits (1–3) and their Robo (1–3) receptors play multiple non‐neuronal roles in development, including in development of muscle, heart and mammary gland. Previous work has demonstrated expression of Slit and Robo family members during limb development, where their functions are unclear. Re...

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Veröffentlicht in:	Developmental dynamics 2021-09, Vol.250 (9), p.1340-1357
Hauptverfasser:	Rafipay, Alexandra, Dun, Xin‐Peng, Parkinson, David B, Erskine, Lynda, Vargesson, Neil
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals bone development Cardiac muscle chicken Chickens forelimb Frogs gene expression Hindlimb Humerus Humerus - metabolism Hybridization Limb buds Mammary gland Mammary glands Membrane Proteins - metabolism Mice mouse mouse knockout Muscles Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Robo Robo protein Signal Transduction - genetics Signaling slit Slit protein Slits
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