Cholesterol Asymmetrically Modulates the Conformational Ensemble of the Nucleotide-Binding Domains of P-Glycoprotein in Lipid Nanodiscs

P-Glycoprotein (P-gp) is an ATP-dependent efflux pump that clears a wide variety of drugs and toxins from cells. P-gp undergoes large-scale structural changes and demonstrates conformational heterogeneity even within a single catalytic or drug-bound state, although the role of heterogeneity remains...

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Veröffentlicht in:	Biochemistry (Easton) 2021-01, Vol.60 (1), p.85-94
Hauptverfasser:	Clouser, Amanda F, Alam, Yasmine H, Atkins, William M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals ATP Binding Cassette Transporter, Subfamily B - chemistry ATP Binding Cassette Transporter, Subfamily B - metabolism Cholesterol - metabolism Hydrolysis Kinetics Lipid Bilayers - metabolism Mice Protein Conformation Protein Domains
Online-Zugang:	Volltext
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