The use of therapeutic plasma exchange for pediatric patients supported on extracorporeal membranous oxygenator therapy: A narrative review

Therapeutic plasma exchange in children is increasingly recognized as a life-saving treatment and is challenged by some technical considerations. As extracorporeal membrane oxygenation has been used for nearly half a century for refractory reversible respiratory and/or cardiac failure in both pediat...

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Veröffentlicht in:Perfusion 2022-03, Vol.37 (2), p.113-122
Hauptverfasser: Kassif Lerner, Reut, Pollak, Uri
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container_title Perfusion
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creator Kassif Lerner, Reut
Pollak, Uri
description Therapeutic plasma exchange in children is increasingly recognized as a life-saving treatment and is challenged by some technical considerations. As extracorporeal membrane oxygenation has been used for nearly half a century for refractory reversible respiratory and/or cardiac failure in both pediatric and adult populations, it may serve as an extracorporeal platform for therapeutic plasma exchange. It is most commonly described in patients with sepsis with multiple organ failure or thrombocytopenia associated multi organ failure. Additional pathophysiological processes of inflammatory and immunological storms might benefit from the combination of extracorporeal membrane oxygenation and plasma exchange. This is a nonmethodological review of English-language reports of therapeutic plasma exchange performed in patients supported by extracorporeal membrane oxygenation, both pediatric and adult, searching six databases, MEDLINE, Clinical Key, GOOGLE SCHOLAR, CINAHL, Cochrane library, and EMBASE.
doi_str_mv 10.1177/0267659120974324
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subjects Adult
Anticoagulants
Apheresis
Child
Exchanging
Extracorporeal membrane oxygenation
Extracorporeal Membrane Oxygenation - adverse effects
Failure
Humans
Immunology
Inflammation
Membranes
Multiple Organ Failure
Oxygenation
Oxygenators, Membrane
Patients
Pediatrics
Plasma
Plasma Exchange - adverse effects
Search engines
Sepsis
Thrombocytopenia
Thrombocytopenia - etiology
title The use of therapeutic plasma exchange for pediatric patients supported on extracorporeal membranous oxygenator therapy: A narrative review
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