Lymph node ratio as an independent prognostic factor for breast cancer-related mortality in patients with node-positive breast cancer
Aim: This study assessed whether prognostic information could be obtained in patients with lymph node (LN)-positive breast cancer based on their LN ratios (LNRs) and explored the relationships between other potential prognostic factors and survival. Setting and Design: This was a retrospective clini...
Gespeichert in:
| Veröffentlicht in: | Journal of cancer research and therapeutics 2020-10, Vol.16 (6), p.1387-1392 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1392 |
|---|---|
| container_issue | 6 |
| container_start_page | 1387 |
| container_title | Journal of cancer research and therapeutics |
| container_volume | 16 |
| creator | Cetin, Ilknur Akay, Sitki Caglar Ozkok, Hale Sengoz, Meric |
| description | Aim: This study assessed whether prognostic information could be obtained in patients with lymph node (LN)-positive breast cancer based on their LN ratios (LNRs) and explored the relationships between other potential prognostic factors and survival.
Setting and Design: This was a retrospective clinical study.
Materials and Methods: This study included 608 women with node-positive nonmetastatic breast cancer. Clinical and pathologic data were retrospectively evaluated. The median age was 51 years (range: 23-84 years). All patients received adjuvant radiotherapy after radical surgery. A total dose of 50 Gy was administered to the chest wall or breast and LN regions with 2 Gy daily fractions. A 10-Gy boost was administered to the breast tumor bed. The cutoff value of LNR was defined as low risk (0.65) in 113 patients. Prognostic variables included patient characteristics, disease characteristics, and interventional factors. The primary endpoint was overall survival and the secondary endpoint was breast cancer-related mortality.
Statistical Analysis Used: Statistical analyses were performed using the Kaplan-Meier method, log-rank test, and Cox regression analysis. P value was required to be |
| doi_str_mv | 10.4103/jcrt.JCRT_1034_19 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2471539604</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2532697519</sourcerecordid><originalsourceid>FETCH-LOGICAL-c456d-e13db106a0ed5fefaf748bcda369590fbf01af8d30ebf6dcd1153abe195fd283</originalsourceid><addsrcrecordid>eNp1kcuKFDEYRoMoTjv6AG4k4GY2NZNbXbKUxisNA9I7FyGV_NHqqUrKJDVNP8C8t-npGVHBRRIC5_tyOQi9puRSUMKvdibmyy_rr1tVdkJR-QStqJRdJSjvnqIVkS2vqOjYGXqR0o6QumWse47OOOeCdYSt0N3mMM0_sA8WcNR5CFgnrD0evIUZyuQznmP47kPKg8FOmxwidmX0EXTK2GhvIFYRRp3B4inErMchH0oDnkthKUh4P-TTGdUc0pCHW_g7_hI9c3pM8OphPUfbD--360_V5vrj5_W7TWVE3dgKKLc9JY0mYGsHTrtWdL2xmjeylsT1jlDtOssJ9K6xxlJac90DlbWzrOPn6OJUW170c4GU1TQkA-OoPYQlKSbaEpANEQV9-w-6C0v05XKK1Zw1sq2pLBQ9USaGlCI4Ncdh0vFQhKijInVUpP5UVDJvHpqXfgL7O_HopADfTsA-jBliuhmXPURV2Bsf9v9vVkV6q-59quNfq3ufSielvXr0yX8BeG6y1Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2532697519</pqid></control><display><type>article</type><title>Lymph node ratio as an independent prognostic factor for breast cancer-related mortality in patients with node-positive breast cancer</title><source>MEDLINE</source><source>Medknow Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Cetin, Ilknur ; Akay, Sitki ; Caglar Ozkok, Hale ; Sengoz, Meric</creator><creatorcontrib>Cetin, Ilknur ; Akay, Sitki ; Caglar Ozkok, Hale ; Sengoz, Meric</creatorcontrib><description>Aim: This study assessed whether prognostic information could be obtained in patients with lymph node (LN)-positive breast cancer based on their LN ratios (LNRs) and explored the relationships between other potential prognostic factors and survival.
Setting and Design: This was a retrospective clinical study.
Materials and Methods: This study included 608 women with node-positive nonmetastatic breast cancer. Clinical and pathologic data were retrospectively evaluated. The median age was 51 years (range: 23-84 years). All patients received adjuvant radiotherapy after radical surgery. A total dose of 50 Gy was administered to the chest wall or breast and LN regions with 2 Gy daily fractions. A 10-Gy boost was administered to the breast tumor bed. The cutoff value of LNR was defined as low risk (<0.21) in 278 patients, intermediate risk (0.21-0.65) in 217 patients, and high risk (>0.65) in 113 patients. Prognostic variables included patient characteristics, disease characteristics, and interventional factors. The primary endpoint was overall survival and the secondary endpoint was breast cancer-related mortality.
Statistical Analysis Used: Statistical analyses were performed using the Kaplan-Meier method, log-rank test, and Cox regression analysis. P value was required to be <0.05.
Results: Within a median follow-up period of 95.4 months (range: 5-232.4 months), overall survival rates for 10 and 15 years were 66% and 53%, respectively. Multivariate analysis revealed that LNR (P = 0.026), estrogen receptor status (ERS) (P = 0.021), age (P = 0.04), and smoking (P = 0.024) were independent significant prognostic factors for overall survival. Breast cancer-related mortality rates at 10 and 15 years were 70.7% and 60%, respectively. LNR (P = 0.03) and ERS (P = 0.002) were independent significant prognostic factors for breast cancer-related mortality.
Conclusions: LNR and ERS were significant prognostic factors for survival at all endpoints.</description><identifier>ISSN: 0973-1482</identifier><identifier>EISSN: 1998-4138</identifier><identifier>DOI: 10.4103/jcrt.JCRT_1034_19</identifier><identifier>PMID: 33342802</identifier><language>eng</language><publisher>India: Wolters Kluwer India Pvt. Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Breast - pathology ; Breast - surgery ; Breast cancer ; Breast Neoplasms - mortality ; Breast Neoplasms - pathology ; Breast Neoplasms - therapy ; Female ; Follow-Up Studies ; Humans ; Kaplan-Meier Estimate ; Lymph Node Excision - statistics & numerical data ; Lymph Node Ratio - statistics & numerical data ; Lymph Nodes - pathology ; Lymph Nodes - surgery ; Lymphatic Metastasis - diagnosis ; Lymphatic Metastasis - pathology ; Lymphatic Metastasis - therapy ; Lymphatic system ; Mastectomy ; Medical prognosis ; Middle Aged ; Mortality ; Prognosis ; Radiotherapy, Adjuvant ; Retrospective Studies ; Risk Assessment - methods ; Risk Assessment - statistics & numerical data ; Survival Rate ; Young Adult</subject><ispartof>Journal of cancer research and therapeutics, 2020-10, Vol.16 (6), p.1387-1392</ispartof><rights>2020. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456d-e13db106a0ed5fefaf748bcda369590fbf01af8d30ebf6dcd1153abe195fd283</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27458,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33342802$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cetin, Ilknur</creatorcontrib><creatorcontrib>Akay, Sitki</creatorcontrib><creatorcontrib>Caglar Ozkok, Hale</creatorcontrib><creatorcontrib>Sengoz, Meric</creatorcontrib><title>Lymph node ratio as an independent prognostic factor for breast cancer-related mortality in patients with node-positive breast cancer</title><title>Journal of cancer research and therapeutics</title><addtitle>J Cancer Res Ther</addtitle><description>Aim: This study assessed whether prognostic information could be obtained in patients with lymph node (LN)-positive breast cancer based on their LN ratios (LNRs) and explored the relationships between other potential prognostic factors and survival.
Setting and Design: This was a retrospective clinical study.
Materials and Methods: This study included 608 women with node-positive nonmetastatic breast cancer. Clinical and pathologic data were retrospectively evaluated. The median age was 51 years (range: 23-84 years). All patients received adjuvant radiotherapy after radical surgery. A total dose of 50 Gy was administered to the chest wall or breast and LN regions with 2 Gy daily fractions. A 10-Gy boost was administered to the breast tumor bed. The cutoff value of LNR was defined as low risk (<0.21) in 278 patients, intermediate risk (0.21-0.65) in 217 patients, and high risk (>0.65) in 113 patients. Prognostic variables included patient characteristics, disease characteristics, and interventional factors. The primary endpoint was overall survival and the secondary endpoint was breast cancer-related mortality.
Statistical Analysis Used: Statistical analyses were performed using the Kaplan-Meier method, log-rank test, and Cox regression analysis. P value was required to be <0.05.
Results: Within a median follow-up period of 95.4 months (range: 5-232.4 months), overall survival rates for 10 and 15 years were 66% and 53%, respectively. Multivariate analysis revealed that LNR (P = 0.026), estrogen receptor status (ERS) (P = 0.021), age (P = 0.04), and smoking (P = 0.024) were independent significant prognostic factors for overall survival. Breast cancer-related mortality rates at 10 and 15 years were 70.7% and 60%, respectively. LNR (P = 0.03) and ERS (P = 0.002) were independent significant prognostic factors for breast cancer-related mortality.
Conclusions: LNR and ERS were significant prognostic factors for survival at all endpoints.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Breast - pathology</subject><subject>Breast - surgery</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - mortality</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - therapy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Lymph Node Excision - statistics & numerical data</subject><subject>Lymph Node Ratio - statistics & numerical data</subject><subject>Lymph Nodes - pathology</subject><subject>Lymph Nodes - surgery</subject><subject>Lymphatic Metastasis - diagnosis</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Lymphatic Metastasis - therapy</subject><subject>Lymphatic system</subject><subject>Mastectomy</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Prognosis</subject><subject>Radiotherapy, Adjuvant</subject><subject>Retrospective Studies</subject><subject>Risk Assessment - methods</subject><subject>Risk Assessment - statistics & numerical data</subject><subject>Survival Rate</subject><subject>Young Adult</subject><issn>0973-1482</issn><issn>1998-4138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kcuKFDEYRoMoTjv6AG4k4GY2NZNbXbKUxisNA9I7FyGV_NHqqUrKJDVNP8C8t-npGVHBRRIC5_tyOQi9puRSUMKvdibmyy_rr1tVdkJR-QStqJRdJSjvnqIVkS2vqOjYGXqR0o6QumWse47OOOeCdYSt0N3mMM0_sA8WcNR5CFgnrD0evIUZyuQznmP47kPKg8FOmxwidmX0EXTK2GhvIFYRRp3B4inErMchH0oDnkthKUh4P-TTGdUc0pCHW_g7_hI9c3pM8OphPUfbD--360_V5vrj5_W7TWVE3dgKKLc9JY0mYGsHTrtWdL2xmjeylsT1jlDtOssJ9K6xxlJac90DlbWzrOPn6OJUW170c4GU1TQkA-OoPYQlKSbaEpANEQV9-w-6C0v05XKK1Zw1sq2pLBQ9USaGlCI4Ncdh0vFQhKijInVUpP5UVDJvHpqXfgL7O_HopADfTsA-jBliuhmXPURV2Bsf9v9vVkV6q-59quNfq3ufSielvXr0yX8BeG6y1Q</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Cetin, Ilknur</creator><creator>Akay, Sitki</creator><creator>Caglar Ozkok, Hale</creator><creator>Sengoz, Meric</creator><general>Wolters Kluwer India Pvt. Ltd</general><general>Medknow Publications & Media Pvt. Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20201001</creationdate><title>Lymph node ratio as an independent prognostic factor for breast cancer-related mortality in patients with node-positive breast cancer</title><author>Cetin, Ilknur ; Akay, Sitki ; Caglar Ozkok, Hale ; Sengoz, Meric</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456d-e13db106a0ed5fefaf748bcda369590fbf01af8d30ebf6dcd1153abe195fd283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Breast - pathology</topic><topic>Breast - surgery</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - mortality</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - therapy</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Lymph Node Excision - statistics & numerical data</topic><topic>Lymph Node Ratio - statistics & numerical data</topic><topic>Lymph Nodes - pathology</topic><topic>Lymph Nodes - surgery</topic><topic>Lymphatic Metastasis - diagnosis</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Lymphatic Metastasis - therapy</topic><topic>Lymphatic system</topic><topic>Mastectomy</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Prognosis</topic><topic>Radiotherapy, Adjuvant</topic><topic>Retrospective Studies</topic><topic>Risk Assessment - methods</topic><topic>Risk Assessment - statistics & numerical data</topic><topic>Survival Rate</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cetin, Ilknur</creatorcontrib><creatorcontrib>Akay, Sitki</creatorcontrib><creatorcontrib>Caglar Ozkok, Hale</creatorcontrib><creatorcontrib>Sengoz, Meric</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cancer research and therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cetin, Ilknur</au><au>Akay, Sitki</au><au>Caglar Ozkok, Hale</au><au>Sengoz, Meric</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lymph node ratio as an independent prognostic factor for breast cancer-related mortality in patients with node-positive breast cancer</atitle><jtitle>Journal of cancer research and therapeutics</jtitle><addtitle>J Cancer Res Ther</addtitle><date>2020-10-01</date><risdate>2020</risdate><volume>16</volume><issue>6</issue><spage>1387</spage><epage>1392</epage><pages>1387-1392</pages><issn>0973-1482</issn><eissn>1998-4138</eissn><abstract>Aim: This study assessed whether prognostic information could be obtained in patients with lymph node (LN)-positive breast cancer based on their LN ratios (LNRs) and explored the relationships between other potential prognostic factors and survival.
Setting and Design: This was a retrospective clinical study.
Materials and Methods: This study included 608 women with node-positive nonmetastatic breast cancer. Clinical and pathologic data were retrospectively evaluated. The median age was 51 years (range: 23-84 years). All patients received adjuvant radiotherapy after radical surgery. A total dose of 50 Gy was administered to the chest wall or breast and LN regions with 2 Gy daily fractions. A 10-Gy boost was administered to the breast tumor bed. The cutoff value of LNR was defined as low risk (<0.21) in 278 patients, intermediate risk (0.21-0.65) in 217 patients, and high risk (>0.65) in 113 patients. Prognostic variables included patient characteristics, disease characteristics, and interventional factors. The primary endpoint was overall survival and the secondary endpoint was breast cancer-related mortality.
Statistical Analysis Used: Statistical analyses were performed using the Kaplan-Meier method, log-rank test, and Cox regression analysis. P value was required to be <0.05.
Results: Within a median follow-up period of 95.4 months (range: 5-232.4 months), overall survival rates for 10 and 15 years were 66% and 53%, respectively. Multivariate analysis revealed that LNR (P = 0.026), estrogen receptor status (ERS) (P = 0.021), age (P = 0.04), and smoking (P = 0.024) were independent significant prognostic factors for overall survival. Breast cancer-related mortality rates at 10 and 15 years were 70.7% and 60%, respectively. LNR (P = 0.03) and ERS (P = 0.002) were independent significant prognostic factors for breast cancer-related mortality.
Conclusions: LNR and ERS were significant prognostic factors for survival at all endpoints.</abstract><cop>India</cop><pub>Wolters Kluwer India Pvt. Ltd</pub><pmid>33342802</pmid><doi>10.4103/jcrt.JCRT_1034_19</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0973-1482 |
| ispartof | Journal of cancer research and therapeutics, 2020-10, Vol.16 (6), p.1387-1392 |
| issn | 0973-1482 1998-4138 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2471539604 |
| source | MEDLINE; Medknow Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Aged, 80 and over Breast - pathology Breast - surgery Breast cancer Breast Neoplasms - mortality Breast Neoplasms - pathology Breast Neoplasms - therapy Female Follow-Up Studies Humans Kaplan-Meier Estimate Lymph Node Excision - statistics & numerical data Lymph Node Ratio - statistics & numerical data Lymph Nodes - pathology Lymph Nodes - surgery Lymphatic Metastasis - diagnosis Lymphatic Metastasis - pathology Lymphatic Metastasis - therapy Lymphatic system Mastectomy Medical prognosis Middle Aged Mortality Prognosis Radiotherapy, Adjuvant Retrospective Studies Risk Assessment - methods Risk Assessment - statistics & numerical data Survival Rate Young Adult |
| title | Lymph node ratio as an independent prognostic factor for breast cancer-related mortality in patients with node-positive breast cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T14%3A46%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Lymph%20node%20ratio%20as%20an%20independent%20prognostic%20factor%20for%20breast%20cancer-related%20mortality%20in%20patients%20with%20node-positive%20breast%20cancer&rft.jtitle=Journal%20of%20cancer%20research%20and%20therapeutics&rft.au=Cetin,%20Ilknur&rft.date=2020-10-01&rft.volume=16&rft.issue=6&rft.spage=1387&rft.epage=1392&rft.pages=1387-1392&rft.issn=0973-1482&rft.eissn=1998-4138&rft_id=info:doi/10.4103/jcrt.JCRT_1034_19&rft_dat=%3Cproquest_cross%3E2532697519%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2532697519&rft_id=info:pmid/33342802&rfr_iscdi=true |