The ubiquitin proteasome system is necessary for efficient proliferation of porcine reproductive and respiratory syndrome virus

•Proteasome inhibitor MG132 inhibits PRRSV proliferation in a dose-dependent manner.•MG132 inhibits PRRSV proliferation at the adsorption and replication steps.•PRRSV infection alters the expression profile of cellular ubiquitin.•Overexpression of ubiquitin partially reverses the MG132 inhibitory ef...

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Veröffentlicht in:	Veterinary microbiology 2021-02, Vol.253, p.108947-108947, Article 108947
Hauptverfasser:	Pang, Yu, Li, Mao, Zhou, Yanrong, Liu, Wei, Tao, Ran, Zhang, Hejin, Xiao, Shaobo, Fang, Liurong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal diseases Cell proliferation Ectopic expression Free ubiquitin Homeostasis MG132 Poly-ubiquitin Porcine reproductive and respiratory syndrome virus (PRRSV) Proteasome inhibitors Proteasomes Quality control Regulatory proteins Ubiquitin Ubiquitin-proteasome system (UPS) Viral replication Virus attachment
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