Lack of Annexin A6 Exacerbates Liver Dysfunction and Reduces Lifespan of Niemann-Pick Type C Protein–Deficient Mice

Niemann-Pick type C (NPC) disease is a lysosomal storage disorder characterized by cholesterol accumulation caused by loss-of-function mutations in the Npc1 gene. NPC disease primarily affects the brain, causing neuronal damage and affecting motor coordination. In addition, considerable liver malfun...

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Veröffentlicht in:	The American journal of pathology 2021-03, Vol.191 (3), p.475-486
Hauptverfasser:	Meneses-Salas, Elsa, Garcia-Forn, Marta, Castany-Pladevall, Carla, Lu, Albert, Fajardo, Alba, Jose, Jaimy, Wahba, Mohamed, Bosch, Marta, Pol, Albert, Tebar, Francesc, Klein, Andrés D., Zanlungo, Silvana, Pérez-Navarro, Esther, Grewal, Thomas, Enrich, Carlos, Rentero, Carles
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Annexin A6 - physiology Behavior, Animal Intracellular Signaling Peptides and Proteins - physiology Liver Diseases - etiology Liver Diseases - metabolism Liver Diseases - pathology Longevity Mice Mice, Knockout
Online-Zugang:	Volltext
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