Diagnostic value of bronchoalveolar lavage fluid cryptococcal antigen-lateral flow immunochromatographic assay for pulmonary cryptococcosis in non-HIV patients
Background: The aim of this study was to investigate the diagnostic value of cryptococcal antigen-lateral flow immunochromatographic assay (CrAg-LFA) in bronchoalveolar lavage fluid (BALF) of patients with pulmonary cryptococcosis (PC). Methods: A total of 308 patients were divided into the PC group...
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| Veröffentlicht in: | Diagnostic microbiology and infectious disease 2021-03, Vol.99 (3), p.115276-115276, Article 115276 |
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| container_title | Diagnostic microbiology and infectious disease |
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| creator | Zeng, Hui-Qing Zhang, Xiao-Bin Cai, Xue-Ying Yang, Dong-Yong Lin, Li Chen, Mei-Jun Guo, Wei-Feng Luo, Xiongbiao |
| description | Background: The aim of this study was to investigate the diagnostic value of cryptococcal antigen-lateral flow immunochromatographic assay (CrAg-LFA) in bronchoalveolar lavage fluid (BALF) of patients with pulmonary cryptococcosis (PC). Methods: A total of 308 patients were divided into the PC group (n = 72) and the non-PC group (n = 236). The clinical data, pathogen detection, radiological imaging, and the detection of the cryptococcal antigen in blood and BALF samples were analyzed. Results: The sensitivity, specificity, positive, and negative predicted values of CrAg-LFA in the serum were 75.0%, 99.6%, 98.2%, and 92.9%, respectively, while those in the BALF were 93.1%, 100.0%, 100.0%, and 97.9%, respectively. The sensitivity of the CrAg-LFA in BALF was significantly higher than that in the serum of the patients in the PC group (P < 0.05). Conclusion: CrAg-LFA has a higher diagnostic value for PC when analyzing BALF samples compared to serum samples. |
| doi_str_mv | 10.1016/j.diagmicrobio.2020.115276 |
| format | Article |
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Methods: A total of 308 patients were divided into the PC group (n = 72) and the non-PC group (n = 236). The clinical data, pathogen detection, radiological imaging, and the detection of the cryptococcal antigen in blood and BALF samples were analyzed. Results: The sensitivity, specificity, positive, and negative predicted values of CrAg-LFA in the serum were 75.0%, 99.6%, 98.2%, and 92.9%, respectively, while those in the BALF were 93.1%, 100.0%, 100.0%, and 97.9%, respectively. The sensitivity of the CrAg-LFA in BALF was significantly higher than that in the serum of the patients in the PC group (P < 0.05). Conclusion: CrAg-LFA has a higher diagnostic value for PC when analyzing BALF samples compared to serum samples.</description><identifier>ISSN: 0732-8893</identifier><identifier>EISSN: 1879-0070</identifier><identifier>DOI: 10.1016/j.diagmicrobio.2020.115276</identifier><identifier>PMID: 33341492</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Bronchoalveolar lavage fluid ; Colloidal gold immunochromatographic assay ; Cryptococcal capsular polysaccharide antigen ; Pulmonary cryptococosis</subject><ispartof>Diagnostic microbiology and infectious disease, 2021-03, Vol.99 (3), p.115276-115276, Article 115276</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-ecaa9e7df8c330d7cfb8030686eff3accf9a8c8c9fd260f9007703772e076e4f3</citedby><cites>FETCH-LOGICAL-c432t-ecaa9e7df8c330d7cfb8030686eff3accf9a8c8c9fd260f9007703772e076e4f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0732889320306532$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33341492$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zeng, Hui-Qing</creatorcontrib><creatorcontrib>Zhang, Xiao-Bin</creatorcontrib><creatorcontrib>Cai, Xue-Ying</creatorcontrib><creatorcontrib>Yang, Dong-Yong</creatorcontrib><creatorcontrib>Lin, Li</creatorcontrib><creatorcontrib>Chen, Mei-Jun</creatorcontrib><creatorcontrib>Guo, Wei-Feng</creatorcontrib><creatorcontrib>Luo, Xiongbiao</creatorcontrib><title>Diagnostic value of bronchoalveolar lavage fluid cryptococcal antigen-lateral flow immunochromatographic assay for pulmonary cryptococcosis in non-HIV patients</title><title>Diagnostic microbiology and infectious disease</title><addtitle>Diagn Microbiol Infect Dis</addtitle><description>Background: The aim of this study was to investigate the diagnostic value of cryptococcal antigen-lateral flow immunochromatographic assay (CrAg-LFA) in bronchoalveolar lavage fluid (BALF) of patients with pulmonary cryptococcosis (PC). Methods: A total of 308 patients were divided into the PC group (n = 72) and the non-PC group (n = 236). The clinical data, pathogen detection, radiological imaging, and the detection of the cryptococcal antigen in blood and BALF samples were analyzed. Results: The sensitivity, specificity, positive, and negative predicted values of CrAg-LFA in the serum were 75.0%, 99.6%, 98.2%, and 92.9%, respectively, while those in the BALF were 93.1%, 100.0%, 100.0%, and 97.9%, respectively. The sensitivity of the CrAg-LFA in BALF was significantly higher than that in the serum of the patients in the PC group (P < 0.05). Conclusion: CrAg-LFA has a higher diagnostic value for PC when analyzing BALF samples compared to serum samples.</description><subject>Bronchoalveolar lavage fluid</subject><subject>Colloidal gold immunochromatographic assay</subject><subject>Cryptococcal capsular polysaccharide antigen</subject><subject>Pulmonary cryptococosis</subject><issn>0732-8893</issn><issn>1879-0070</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqNkcFu1DAQhi0EotvCKyCLE5csTpzGCTfUAq1UiQtwtWad8a5XjifYzlb7NLwqrrZFPXIajeaffzT_x9j7WqxrUXcf9-vRwXZyJtLG0boRTRnUl43qXrBV3auhEkKJl2wllGyqvh_kGTtPaS9E3QyteM3OpJRt3Q7Niv25LlaBUnaGH8AvyMnyTaRgdgT-gOQhcg8H2CK3fnEjN_E4ZzJkDHgOIbsthspDxlh66-meu2laApldpAkybSPMu-IOKcGRW4p8XvxEAeLxmRcll7gLPFCobm5_8Rmyw5DTG_bKgk_49rFesJ9fv_y4uqnuvn-7vfp8V5lWNrlCAzCgGm1vpBSjMnbTCym6vkNrJRhjB-hNbwY7Np2wQwlICalUg0J12Fp5wT6cfOdIvxdMWU8uGfQeAtKSdNOq-lJ2Q98V6aeTtOSfUkSr5-im8o6uhX4ApPf6OSD9AEifAJXld493ls2E47_VJyJFcH0SYPn24DDqZEoSBkcX0WQ9kvufO38B5i6ujg</recordid><startdate>202103</startdate><enddate>202103</enddate><creator>Zeng, Hui-Qing</creator><creator>Zhang, Xiao-Bin</creator><creator>Cai, Xue-Ying</creator><creator>Yang, Dong-Yong</creator><creator>Lin, Li</creator><creator>Chen, Mei-Jun</creator><creator>Guo, Wei-Feng</creator><creator>Luo, Xiongbiao</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202103</creationdate><title>Diagnostic value of bronchoalveolar lavage fluid cryptococcal antigen-lateral flow immunochromatographic assay for pulmonary cryptococcosis in non-HIV patients</title><author>Zeng, Hui-Qing ; Zhang, Xiao-Bin ; Cai, Xue-Ying ; Yang, Dong-Yong ; Lin, Li ; Chen, Mei-Jun ; Guo, Wei-Feng ; Luo, Xiongbiao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-ecaa9e7df8c330d7cfb8030686eff3accf9a8c8c9fd260f9007703772e076e4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Bronchoalveolar lavage fluid</topic><topic>Colloidal gold immunochromatographic assay</topic><topic>Cryptococcal capsular polysaccharide antigen</topic><topic>Pulmonary cryptococosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zeng, Hui-Qing</creatorcontrib><creatorcontrib>Zhang, Xiao-Bin</creatorcontrib><creatorcontrib>Cai, Xue-Ying</creatorcontrib><creatorcontrib>Yang, Dong-Yong</creatorcontrib><creatorcontrib>Lin, Li</creatorcontrib><creatorcontrib>Chen, Mei-Jun</creatorcontrib><creatorcontrib>Guo, Wei-Feng</creatorcontrib><creatorcontrib>Luo, Xiongbiao</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diagnostic microbiology and infectious disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zeng, Hui-Qing</au><au>Zhang, Xiao-Bin</au><au>Cai, Xue-Ying</au><au>Yang, Dong-Yong</au><au>Lin, Li</au><au>Chen, Mei-Jun</au><au>Guo, Wei-Feng</au><au>Luo, Xiongbiao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic value of bronchoalveolar lavage fluid cryptococcal antigen-lateral flow immunochromatographic assay for pulmonary cryptococcosis in non-HIV patients</atitle><jtitle>Diagnostic microbiology and infectious disease</jtitle><addtitle>Diagn Microbiol Infect Dis</addtitle><date>2021-03</date><risdate>2021</risdate><volume>99</volume><issue>3</issue><spage>115276</spage><epage>115276</epage><pages>115276-115276</pages><artnum>115276</artnum><issn>0732-8893</issn><eissn>1879-0070</eissn><abstract>Background: The aim of this study was to investigate the diagnostic value of cryptococcal antigen-lateral flow immunochromatographic assay (CrAg-LFA) in bronchoalveolar lavage fluid (BALF) of patients with pulmonary cryptococcosis (PC). Methods: A total of 308 patients were divided into the PC group (n = 72) and the non-PC group (n = 236). The clinical data, pathogen detection, radiological imaging, and the detection of the cryptococcal antigen in blood and BALF samples were analyzed. Results: The sensitivity, specificity, positive, and negative predicted values of CrAg-LFA in the serum were 75.0%, 99.6%, 98.2%, and 92.9%, respectively, while those in the BALF were 93.1%, 100.0%, 100.0%, and 97.9%, respectively. The sensitivity of the CrAg-LFA in BALF was significantly higher than that in the serum of the patients in the PC group (P < 0.05). Conclusion: CrAg-LFA has a higher diagnostic value for PC when analyzing BALF samples compared to serum samples.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>33341492</pmid><doi>10.1016/j.diagmicrobio.2020.115276</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | Elsevier ScienceDirect Journals |
| subjects | Bronchoalveolar lavage fluid Colloidal gold immunochromatographic assay Cryptococcal capsular polysaccharide antigen Pulmonary cryptococosis |
| title | Diagnostic value of bronchoalveolar lavage fluid cryptococcal antigen-lateral flow immunochromatographic assay for pulmonary cryptococcosis in non-HIV patients |
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