The miR-623/CXCL12 axis inhibits LPS-induced nucleus pulposus cell apoptosis and senescence

•miR-623 expression based on bioinformatics and experimental analyses.•Specific effects of miR-623 on LPS-stimulated nucleus pulposus cells (NPCs).•miR-623 directly binds the 3′-UTR of CXCL12.•Effects of CXCL12 silencing on LPS-stimulated NPCs.•miR-623 protects NPCs against LPS-induced injury throug...

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Veröffentlicht in:	Mechanisms of ageing and development 2021-03, Vol.194, p.111417-111417, Article 111417
Hauptverfasser:	Zhong, Hua, Zhou, Zhihong, Guo, Lebin, Liu, Fusheng, Zheng, Bowen, Bi, Sheng, Tian, Chenjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis CXCL12 Intervertebral disc degeneration (IDD) miR-623 Nucleus pulposus cell (NPC) Senescence
Online-Zugang:	Volltext
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