Overexpression of Sine Oculis Homeobox Homolog 2 Predicts Poor Survival and Clinical Parameters of Patients with Colon Adenocarcinoma

Overexpression of Sine Oculis Homeobox Homolog 2 Predicts Poor Survival and Clinical Parameters of Patients with Colon Adenocarcinoma

Sine oculis homeobox homolog 2 (Six2), a developmental transcription factor, is known to be correlated with the development and prognosis of various cancers. In this study, we explored the prognostic value of Six2 in colon adenocarcinoma (COAD). Wilcoxon signed-rank test and logistic regression were...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Annals of clinical and laboratory science 2020-11, Vol.50 (6), p.717-725
Hauptverfasser: Jiang, Yaofei, Zhou, Bin, Liang, Bo, Zeng, Fei, Zou, Zhenhong
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 725
container_issue 6
container_start_page 717
container_title Annals of clinical and laboratory science
container_volume 50
creator Jiang, Yaofei
Zhou, Bin
Liang, Bo
Zeng, Fei
Zou, Zhenhong
description Sine oculis homeobox homolog 2 (Six2), a developmental transcription factor, is known to be correlated with the development and prognosis of various cancers. In this study, we explored the prognostic value of Six2 in colon adenocarcinoma (COAD). Wilcoxon signed-rank test and logistic regression were applied to identify relationship between clinical features and Six2 expression. The effect of Six2 expression and clinical features on the survival of COAD patients was explored using Kaplan-Meier and Cox regression analyses. Gene Set Enrichment Analysis (GSEA) was performed utilizing TCGA dataset. Compared to adjacent normal tissues, Six2 was highly expressed in COAD. Overexpression of Six2 in COAD was significantly associated with M classification (OR=2.557, positive vs. negative), N classification (OR=2.636, N2 vs. N0), and stage (OR=1.864, III vs. I) (all -values
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_2471458937</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2471458937</sourcerecordid><originalsourceid>FETCH-LOGICAL-p211t-d1eea4715c3b1f4d6f14594ede6550341a9d0a784cb16ea58d1955486b424b1a3</originalsourceid><addsrcrecordid>eNo1kF9LwzAUxYMgbk6_guTRl0LSJv3zOIo6YbDC9LncJrcaaZOatHN-AL-3Hc7zcu-Bc39wzwVZcilZlLOcLch1CB-MxYUQ7Iosklkiy-WS_OwO6PE4eAzBOEtdS_fGIt2pqTOBblyPrnHH0-I690ZjWnnURo2BVs55up_8wRygo2A1LTtjjZpNBR56HNGHE7CC0aCdL77M-E7LmWPpWqN1Crwy1vVwQy5b6ALenueKvD4-vJSbaLt7ei7X22iIOR8jzRFBZFyqpOGt0GnLhSwEakznTxPBodAMslyohqcIMte8kFLkaSNi0XBIVuT-jzt49zlhGOveBIVdBxbdFOp4hguZF0k2R-_O0anpUdeDNz347_q_uuQXtzRrHw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2471458937</pqid></control><display><type>article</type><title>Overexpression of Sine Oculis Homeobox Homolog 2 Predicts Poor Survival and Clinical Parameters of Patients with Colon Adenocarcinoma</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Jiang, Yaofei ; Zhou, Bin ; Liang, Bo ; Zeng, Fei ; Zou, Zhenhong</creator><creatorcontrib>Jiang, Yaofei ; Zhou, Bin ; Liang, Bo ; Zeng, Fei ; Zou, Zhenhong</creatorcontrib><description>Sine oculis homeobox homolog 2 (Six2), a developmental transcription factor, is known to be correlated with the development and prognosis of various cancers. In this study, we explored the prognostic value of Six2 in colon adenocarcinoma (COAD). Wilcoxon signed-rank test and logistic regression were applied to identify relationship between clinical features and Six2 expression. The effect of Six2 expression and clinical features on the survival of COAD patients was explored using Kaplan-Meier and Cox regression analyses. Gene Set Enrichment Analysis (GSEA) was performed utilizing TCGA dataset. Compared to adjacent normal tissues, Six2 was highly expressed in COAD. Overexpression of Six2 in COAD was significantly associated with M classification (OR=2.557, positive vs. negative), N classification (OR=2.636, N2 vs. N0), and stage (OR=1.864, III vs. I) (all -values&lt;0.05). Patients with higher Six2 expression had significantly poor overall survival (OS, =0.003). The univariate analysis showed that high expression of Six2 was significantly correlated with a poor OS (HR=1.135, 95%Cl 1.038-1.241; =0.005). The multivariate analysis demonstrated that Six2 was an independent predictor of OS (HR=1.107, 95%Cl 1.007-1.216; =0.036). According to GSEA, differentially enriched pathways in the Six2 high expression phenotype, included the TGF- β and Wnt signaling pathway. Six2 may be a valuable biomarker and potential therapeutic target for the treatment of COAD.</description><identifier>EISSN: 1550-8080</identifier><identifier>PMID: 33334785</identifier><language>eng</language><publisher>United States</publisher><ispartof>Annals of clinical and laboratory science, 2020-11, Vol.50 (6), p.717-725</ispartof><rights>2020 by the Association of Clinical Scientists, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33334785$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Yaofei</creatorcontrib><creatorcontrib>Zhou, Bin</creatorcontrib><creatorcontrib>Liang, Bo</creatorcontrib><creatorcontrib>Zeng, Fei</creatorcontrib><creatorcontrib>Zou, Zhenhong</creatorcontrib><title>Overexpression of Sine Oculis Homeobox Homolog 2 Predicts Poor Survival and Clinical Parameters of Patients with Colon Adenocarcinoma</title><title>Annals of clinical and laboratory science</title><addtitle>Ann Clin Lab Sci</addtitle><description>Sine oculis homeobox homolog 2 (Six2), a developmental transcription factor, is known to be correlated with the development and prognosis of various cancers. In this study, we explored the prognostic value of Six2 in colon adenocarcinoma (COAD). Wilcoxon signed-rank test and logistic regression were applied to identify relationship between clinical features and Six2 expression. The effect of Six2 expression and clinical features on the survival of COAD patients was explored using Kaplan-Meier and Cox regression analyses. Gene Set Enrichment Analysis (GSEA) was performed utilizing TCGA dataset. Compared to adjacent normal tissues, Six2 was highly expressed in COAD. Overexpression of Six2 in COAD was significantly associated with M classification (OR=2.557, positive vs. negative), N classification (OR=2.636, N2 vs. N0), and stage (OR=1.864, III vs. I) (all -values&lt;0.05). Patients with higher Six2 expression had significantly poor overall survival (OS, =0.003). The univariate analysis showed that high expression of Six2 was significantly correlated with a poor OS (HR=1.135, 95%Cl 1.038-1.241; =0.005). The multivariate analysis demonstrated that Six2 was an independent predictor of OS (HR=1.107, 95%Cl 1.007-1.216; =0.036). According to GSEA, differentially enriched pathways in the Six2 high expression phenotype, included the TGF- β and Wnt signaling pathway. Six2 may be a valuable biomarker and potential therapeutic target for the treatment of COAD.</description><issn>1550-8080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNo1kF9LwzAUxYMgbk6_guTRl0LSJv3zOIo6YbDC9LncJrcaaZOatHN-AL-3Hc7zcu-Bc39wzwVZcilZlLOcLch1CB-MxYUQ7Iosklkiy-WS_OwO6PE4eAzBOEtdS_fGIt2pqTOBblyPrnHH0-I690ZjWnnURo2BVs55up_8wRygo2A1LTtjjZpNBR56HNGHE7CC0aCdL77M-E7LmWPpWqN1Crwy1vVwQy5b6ALenueKvD4-vJSbaLt7ei7X22iIOR8jzRFBZFyqpOGt0GnLhSwEakznTxPBodAMslyohqcIMte8kFLkaSNi0XBIVuT-jzt49zlhGOveBIVdBxbdFOp4hguZF0k2R-_O0anpUdeDNz347_q_uuQXtzRrHw</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Jiang, Yaofei</creator><creator>Zhou, Bin</creator><creator>Liang, Bo</creator><creator>Zeng, Fei</creator><creator>Zou, Zhenhong</creator><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20201101</creationdate><title>Overexpression of Sine Oculis Homeobox Homolog 2 Predicts Poor Survival and Clinical Parameters of Patients with Colon Adenocarcinoma</title><author>Jiang, Yaofei ; Zhou, Bin ; Liang, Bo ; Zeng, Fei ; Zou, Zhenhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-d1eea4715c3b1f4d6f14594ede6550341a9d0a784cb16ea58d1955486b424b1a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Yaofei</creatorcontrib><creatorcontrib>Zhou, Bin</creatorcontrib><creatorcontrib>Liang, Bo</creatorcontrib><creatorcontrib>Zeng, Fei</creatorcontrib><creatorcontrib>Zou, Zhenhong</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of clinical and laboratory science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Yaofei</au><au>Zhou, Bin</au><au>Liang, Bo</au><au>Zeng, Fei</au><au>Zou, Zhenhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Overexpression of Sine Oculis Homeobox Homolog 2 Predicts Poor Survival and Clinical Parameters of Patients with Colon Adenocarcinoma</atitle><jtitle>Annals of clinical and laboratory science</jtitle><addtitle>Ann Clin Lab Sci</addtitle><date>2020-11-01</date><risdate>2020</risdate><volume>50</volume><issue>6</issue><spage>717</spage><epage>725</epage><pages>717-725</pages><eissn>1550-8080</eissn><abstract>Sine oculis homeobox homolog 2 (Six2), a developmental transcription factor, is known to be correlated with the development and prognosis of various cancers. In this study, we explored the prognostic value of Six2 in colon adenocarcinoma (COAD). Wilcoxon signed-rank test and logistic regression were applied to identify relationship between clinical features and Six2 expression. The effect of Six2 expression and clinical features on the survival of COAD patients was explored using Kaplan-Meier and Cox regression analyses. Gene Set Enrichment Analysis (GSEA) was performed utilizing TCGA dataset. Compared to adjacent normal tissues, Six2 was highly expressed in COAD. Overexpression of Six2 in COAD was significantly associated with M classification (OR=2.557, positive vs. negative), N classification (OR=2.636, N2 vs. N0), and stage (OR=1.864, III vs. I) (all -values&lt;0.05). Patients with higher Six2 expression had significantly poor overall survival (OS, =0.003). The univariate analysis showed that high expression of Six2 was significantly correlated with a poor OS (HR=1.135, 95%Cl 1.038-1.241; =0.005). The multivariate analysis demonstrated that Six2 was an independent predictor of OS (HR=1.107, 95%Cl 1.007-1.216; =0.036). According to GSEA, differentially enriched pathways in the Six2 high expression phenotype, included the TGF- β and Wnt signaling pathway. Six2 may be a valuable biomarker and potential therapeutic target for the treatment of COAD.</abstract><cop>United States</cop><pmid>33334785</pmid><tpages>9</tpages></addata></record>
fulltext fulltext
identifier EISSN: 1550-8080
ispartof Annals of clinical and laboratory science, 2020-11, Vol.50 (6), p.717-725
issn 1550-8080
language eng
recordid cdi_proquest_miscellaneous_2471458937
source Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
title Overexpression of Sine Oculis Homeobox Homolog 2 Predicts Poor Survival and Clinical Parameters of Patients with Colon Adenocarcinoma
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T17%3A40%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Overexpression%20of%20Sine%20Oculis%20Homeobox%20Homolog%202%20Predicts%20Poor%20Survival%20and%20Clinical%20Parameters%20of%20Patients%20with%20Colon%20Adenocarcinoma&rft.jtitle=Annals%20of%20clinical%20and%20laboratory%20science&rft.au=Jiang,%20Yaofei&rft.date=2020-11-01&rft.volume=50&rft.issue=6&rft.spage=717&rft.epage=725&rft.pages=717-725&rft.eissn=1550-8080&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E2471458937%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2471458937&rft_id=info:pmid/33334785&rfr_iscdi=true