Voltage-gated sodium channel Nav1.5 promotes tumor progression and enhances chemosensitivity to 5-fluorouracil in colorectal cancer

Nav1.5, encoded by SCN5A, has been associated with metastasis in colorectal cancer (CRC). Here, we investigated the mechanism by which Nav1.5 regulates tumor progression and whether Nav1.5 influences chemosensitivity to 5-fluorouracil (5-FU) in CRCs. CRC cases were evaluated for Nav1.5 expression. E...

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Veröffentlicht in:	Cancer letters 2021-03, Vol.500, p.119-131
Hauptverfasser:	Sui, Qiaoqi, Peng, Jianhong, Han, Kai, Lin, Junzhong, Zhang, Rongxin, Ou, Qingjian, Qin, Jiayi, Deng, Yuxiang, Zhou, Wenhao, Kong, Lingheng, Tang, Jinghua, Xiao, Binyi, Li, Yuan, Yu, Long, Fang, Yujing, Ding, Pei-Rong, Pan, Zhizhong
Format:	Artikel
Sprache:	eng
Schlagworte:	5-fluorouracil-stimulated apoptosis Calcium influx Calmodulin Colorectal cancer Nav1.5
Online-Zugang:	Volltext
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