Degenerative Lumbar Stenosis Surgery: Predictive Factors of Clinical Outcome—Experience with 1001 Patients
Degenerative lumbar spinal stenosis (DLSS) carries a high risk of morbidity and represents a financial burden to society. A late diagnosis can lead to severe disability. Although lumbar decompressive surgery has been widely used worldwide, the proper preoperative factors to define the ideal candidat...
Gespeichert in:
Veröffentlicht in: | World neurosurgery 2021-03, Vol.147, p.e306-e314 |
---|---|
Hauptverfasser: | , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | e314 |
---|---|
container_issue | |
container_start_page | e306 |
container_title | World neurosurgery |
container_volume | 147 |
creator | Aimar, Enrico Iess, Guglielmo Gaetani, Paolo Galbiati, Tommaso Francesco Isidori, Alessandra Lavanga, Vito Longhitano, Federico Menghetti, Claudia Messina, Alberto Luca Zekaj, Edvin Broggi, Giovanni |
description | Degenerative lumbar spinal stenosis (DLSS) carries a high risk of morbidity and represents a financial burden to society. A late diagnosis can lead to severe disability. Although lumbar decompressive surgery has been widely used worldwide, the proper preoperative factors to define the ideal candidates for decompression are missing.
A total of 1001 patients who had undergone decompressive surgery from 2012 to 2019 for DLSS were screened for the presence of 9 clinical and radiological parameters. For all cases, the differences between the baseline and postoperative Oswestry disability index were calculated and the results categorized as 5 different classes (ranging from very poor outcomes to excellent outcomes) according to the specific scores. Generalized ordinal logistic regression was then used to analyze the significance of the 9 parameters (coded as dummy variables) in predicting the outcome as measured by Oswestry disability index improvement after surgery.
Of the 9 parameters, 8 were found to be significant predictors. The radiological grade of compression was the strongest, followed by polyneuropathy, obesity, symptom duration, gait autonomy, radicular deficits, American Society of Anesthesiologists score, and level of surgery. In contrast, previous back surgery was not predictive of the outcome.
Our findings have indicated that the ideal candidate for surgery will have the following preoperative characteristics: Schizas grade D, no signs of peripheral polyneuropathy, body mass index |
doi_str_mv | 10.1016/j.wneu.2020.12.048 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2471456917</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1878875020326140</els_id><sourcerecordid>2471456917</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-df6b4403a4f62553bbbaab2071317da5b4f12a1ef75c33a698ba1fe2d0fe678b3</originalsourceid><addsrcrecordid>eNp9kMtqWzEQhkVJqYPrF-giaNmNHd2OdByyCc6tYHAg7VpIOiNH5lxcSSeXXR6iT9gnybGdZtnZzDB888N8CH2jZEYJlaeb2VML_YwRNizYjIjyEzqmpSqnpZLzo4-5ICM0SWlDhuJUlIp_QSPOuSCKyWNUX8IaWogmh0fAy76xJuL7DG2XQsL3fVxDfDnDdxGq4PbMtXG5iwl3Hi_q0AZnarzqs-sa-Pv65-p5CzFA6wA_hfyAKSEU3w3p0Ob0FX32pk4wee9j9Ov66ufidrpc3fxYXCynjhcyTysvrRCEG-ElKwpurTXGMqIop6oyhRWeMkPBq8JxbuS8tIZ6YBXxIFVp-Rh9P-RuY_e7h5R1E5KDujYtdH3STCgqCjmnakDZAXWxSymC19sYGhNfNCV6J1pv9E603onWlOlB9HB08p7f2waqj5N_Wgfg_ADA8OVjgKiT20upQgSXddWF_-W_AY7lkPM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2471456917</pqid></control><display><type>article</type><title>Degenerative Lumbar Stenosis Surgery: Predictive Factors of Clinical Outcome—Experience with 1001 Patients</title><source>ScienceDirect Journals (5 years ago - present)</source><creator>Aimar, Enrico ; Iess, Guglielmo ; Gaetani, Paolo ; Galbiati, Tommaso Francesco ; Isidori, Alessandra ; Lavanga, Vito ; Longhitano, Federico ; Menghetti, Claudia ; Messina, Alberto Luca ; Zekaj, Edvin ; Broggi, Giovanni</creator><creatorcontrib>Aimar, Enrico ; Iess, Guglielmo ; Gaetani, Paolo ; Galbiati, Tommaso Francesco ; Isidori, Alessandra ; Lavanga, Vito ; Longhitano, Federico ; Menghetti, Claudia ; Messina, Alberto Luca ; Zekaj, Edvin ; Broggi, Giovanni</creatorcontrib><description>Degenerative lumbar spinal stenosis (DLSS) carries a high risk of morbidity and represents a financial burden to society. A late diagnosis can lead to severe disability. Although lumbar decompressive surgery has been widely used worldwide, the proper preoperative factors to define the ideal candidates for decompression are missing.
A total of 1001 patients who had undergone decompressive surgery from 2012 to 2019 for DLSS were screened for the presence of 9 clinical and radiological parameters. For all cases, the differences between the baseline and postoperative Oswestry disability index were calculated and the results categorized as 5 different classes (ranging from very poor outcomes to excellent outcomes) according to the specific scores. Generalized ordinal logistic regression was then used to analyze the significance of the 9 parameters (coded as dummy variables) in predicting the outcome as measured by Oswestry disability index improvement after surgery.
Of the 9 parameters, 8 were found to be significant predictors. The radiological grade of compression was the strongest, followed by polyneuropathy, obesity, symptom duration, gait autonomy, radicular deficits, American Society of Anesthesiologists score, and level of surgery. In contrast, previous back surgery was not predictive of the outcome.
Our findings have indicated that the ideal candidate for surgery will have the following preoperative characteristics: Schizas grade D, no signs of peripheral polyneuropathy, body mass index <30 kg/m2, symptom duration of <2 years, gait autonomy <100 m, no radicular deficits, 1 level of stenosis, and an American Society of Anesthesiologists score of 1, 2, or 3.</description><identifier>ISSN: 1878-8750</identifier><identifier>EISSN: 1878-8769</identifier><identifier>DOI: 10.1016/j.wneu.2020.12.048</identifier><identifier>PMID: 33340726</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Clinical outcome ; Lumbar stenosis ; Predictive factors ; Retrospective study ; Surgery</subject><ispartof>World neurosurgery, 2021-03, Vol.147, p.e306-e314</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-df6b4403a4f62553bbbaab2071317da5b4f12a1ef75c33a698ba1fe2d0fe678b3</citedby><cites>FETCH-LOGICAL-c356t-df6b4403a4f62553bbbaab2071317da5b4f12a1ef75c33a698ba1fe2d0fe678b3</cites><orcidid>0000-0003-3357-5233 ; 0000-0001-6183-6125</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.wneu.2020.12.048$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33340726$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aimar, Enrico</creatorcontrib><creatorcontrib>Iess, Guglielmo</creatorcontrib><creatorcontrib>Gaetani, Paolo</creatorcontrib><creatorcontrib>Galbiati, Tommaso Francesco</creatorcontrib><creatorcontrib>Isidori, Alessandra</creatorcontrib><creatorcontrib>Lavanga, Vito</creatorcontrib><creatorcontrib>Longhitano, Federico</creatorcontrib><creatorcontrib>Menghetti, Claudia</creatorcontrib><creatorcontrib>Messina, Alberto Luca</creatorcontrib><creatorcontrib>Zekaj, Edvin</creatorcontrib><creatorcontrib>Broggi, Giovanni</creatorcontrib><title>Degenerative Lumbar Stenosis Surgery: Predictive Factors of Clinical Outcome—Experience with 1001 Patients</title><title>World neurosurgery</title><addtitle>World Neurosurg</addtitle><description>Degenerative lumbar spinal stenosis (DLSS) carries a high risk of morbidity and represents a financial burden to society. A late diagnosis can lead to severe disability. Although lumbar decompressive surgery has been widely used worldwide, the proper preoperative factors to define the ideal candidates for decompression are missing.
A total of 1001 patients who had undergone decompressive surgery from 2012 to 2019 for DLSS were screened for the presence of 9 clinical and radiological parameters. For all cases, the differences between the baseline and postoperative Oswestry disability index were calculated and the results categorized as 5 different classes (ranging from very poor outcomes to excellent outcomes) according to the specific scores. Generalized ordinal logistic regression was then used to analyze the significance of the 9 parameters (coded as dummy variables) in predicting the outcome as measured by Oswestry disability index improvement after surgery.
Of the 9 parameters, 8 were found to be significant predictors. The radiological grade of compression was the strongest, followed by polyneuropathy, obesity, symptom duration, gait autonomy, radicular deficits, American Society of Anesthesiologists score, and level of surgery. In contrast, previous back surgery was not predictive of the outcome.
Our findings have indicated that the ideal candidate for surgery will have the following preoperative characteristics: Schizas grade D, no signs of peripheral polyneuropathy, body mass index <30 kg/m2, symptom duration of <2 years, gait autonomy <100 m, no radicular deficits, 1 level of stenosis, and an American Society of Anesthesiologists score of 1, 2, or 3.</description><subject>Clinical outcome</subject><subject>Lumbar stenosis</subject><subject>Predictive factors</subject><subject>Retrospective study</subject><subject>Surgery</subject><issn>1878-8750</issn><issn>1878-8769</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kMtqWzEQhkVJqYPrF-giaNmNHd2OdByyCc6tYHAg7VpIOiNH5lxcSSeXXR6iT9gnybGdZtnZzDB888N8CH2jZEYJlaeb2VML_YwRNizYjIjyEzqmpSqnpZLzo4-5ICM0SWlDhuJUlIp_QSPOuSCKyWNUX8IaWogmh0fAy76xJuL7DG2XQsL3fVxDfDnDdxGq4PbMtXG5iwl3Hi_q0AZnarzqs-sa-Pv65-p5CzFA6wA_hfyAKSEU3w3p0Ob0FX32pk4wee9j9Ov66ufidrpc3fxYXCynjhcyTysvrRCEG-ElKwpurTXGMqIop6oyhRWeMkPBq8JxbuS8tIZ6YBXxIFVp-Rh9P-RuY_e7h5R1E5KDujYtdH3STCgqCjmnakDZAXWxSymC19sYGhNfNCV6J1pv9E603onWlOlB9HB08p7f2waqj5N_Wgfg_ADA8OVjgKiT20upQgSXddWF_-W_AY7lkPM</recordid><startdate>202103</startdate><enddate>202103</enddate><creator>Aimar, Enrico</creator><creator>Iess, Guglielmo</creator><creator>Gaetani, Paolo</creator><creator>Galbiati, Tommaso Francesco</creator><creator>Isidori, Alessandra</creator><creator>Lavanga, Vito</creator><creator>Longhitano, Federico</creator><creator>Menghetti, Claudia</creator><creator>Messina, Alberto Luca</creator><creator>Zekaj, Edvin</creator><creator>Broggi, Giovanni</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3357-5233</orcidid><orcidid>https://orcid.org/0000-0001-6183-6125</orcidid></search><sort><creationdate>202103</creationdate><title>Degenerative Lumbar Stenosis Surgery: Predictive Factors of Clinical Outcome—Experience with 1001 Patients</title><author>Aimar, Enrico ; Iess, Guglielmo ; Gaetani, Paolo ; Galbiati, Tommaso Francesco ; Isidori, Alessandra ; Lavanga, Vito ; Longhitano, Federico ; Menghetti, Claudia ; Messina, Alberto Luca ; Zekaj, Edvin ; Broggi, Giovanni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-df6b4403a4f62553bbbaab2071317da5b4f12a1ef75c33a698ba1fe2d0fe678b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Clinical outcome</topic><topic>Lumbar stenosis</topic><topic>Predictive factors</topic><topic>Retrospective study</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aimar, Enrico</creatorcontrib><creatorcontrib>Iess, Guglielmo</creatorcontrib><creatorcontrib>Gaetani, Paolo</creatorcontrib><creatorcontrib>Galbiati, Tommaso Francesco</creatorcontrib><creatorcontrib>Isidori, Alessandra</creatorcontrib><creatorcontrib>Lavanga, Vito</creatorcontrib><creatorcontrib>Longhitano, Federico</creatorcontrib><creatorcontrib>Menghetti, Claudia</creatorcontrib><creatorcontrib>Messina, Alberto Luca</creatorcontrib><creatorcontrib>Zekaj, Edvin</creatorcontrib><creatorcontrib>Broggi, Giovanni</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>World neurosurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aimar, Enrico</au><au>Iess, Guglielmo</au><au>Gaetani, Paolo</au><au>Galbiati, Tommaso Francesco</au><au>Isidori, Alessandra</au><au>Lavanga, Vito</au><au>Longhitano, Federico</au><au>Menghetti, Claudia</au><au>Messina, Alberto Luca</au><au>Zekaj, Edvin</au><au>Broggi, Giovanni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Degenerative Lumbar Stenosis Surgery: Predictive Factors of Clinical Outcome—Experience with 1001 Patients</atitle><jtitle>World neurosurgery</jtitle><addtitle>World Neurosurg</addtitle><date>2021-03</date><risdate>2021</risdate><volume>147</volume><spage>e306</spage><epage>e314</epage><pages>e306-e314</pages><issn>1878-8750</issn><eissn>1878-8769</eissn><abstract>Degenerative lumbar spinal stenosis (DLSS) carries a high risk of morbidity and represents a financial burden to society. A late diagnosis can lead to severe disability. Although lumbar decompressive surgery has been widely used worldwide, the proper preoperative factors to define the ideal candidates for decompression are missing.
A total of 1001 patients who had undergone decompressive surgery from 2012 to 2019 for DLSS were screened for the presence of 9 clinical and radiological parameters. For all cases, the differences between the baseline and postoperative Oswestry disability index were calculated and the results categorized as 5 different classes (ranging from very poor outcomes to excellent outcomes) according to the specific scores. Generalized ordinal logistic regression was then used to analyze the significance of the 9 parameters (coded as dummy variables) in predicting the outcome as measured by Oswestry disability index improvement after surgery.
Of the 9 parameters, 8 were found to be significant predictors. The radiological grade of compression was the strongest, followed by polyneuropathy, obesity, symptom duration, gait autonomy, radicular deficits, American Society of Anesthesiologists score, and level of surgery. In contrast, previous back surgery was not predictive of the outcome.
Our findings have indicated that the ideal candidate for surgery will have the following preoperative characteristics: Schizas grade D, no signs of peripheral polyneuropathy, body mass index <30 kg/m2, symptom duration of <2 years, gait autonomy <100 m, no radicular deficits, 1 level of stenosis, and an American Society of Anesthesiologists score of 1, 2, or 3.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>33340726</pmid><doi>10.1016/j.wneu.2020.12.048</doi><orcidid>https://orcid.org/0000-0003-3357-5233</orcidid><orcidid>https://orcid.org/0000-0001-6183-6125</orcidid></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1878-8750 |
ispartof | World neurosurgery, 2021-03, Vol.147, p.e306-e314 |
issn | 1878-8750 1878-8769 |
language | eng |
recordid | cdi_proquest_miscellaneous_2471456917 |
source | ScienceDirect Journals (5 years ago - present) |
subjects | Clinical outcome Lumbar stenosis Predictive factors Retrospective study Surgery |
title | Degenerative Lumbar Stenosis Surgery: Predictive Factors of Clinical Outcome—Experience with 1001 Patients |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T04%3A13%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Degenerative%20Lumbar%20Stenosis%20Surgery:%20Predictive%20Factors%20of%20Clinical%20Outcome%E2%80%94Experience%20with%201001%20Patients&rft.jtitle=World%20neurosurgery&rft.au=Aimar,%20Enrico&rft.date=2021-03&rft.volume=147&rft.spage=e306&rft.epage=e314&rft.pages=e306-e314&rft.issn=1878-8750&rft.eissn=1878-8769&rft_id=info:doi/10.1016/j.wneu.2020.12.048&rft_dat=%3Cproquest_cross%3E2471456917%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2471456917&rft_id=info:pmid/33340726&rft_els_id=S1878875020326140&rfr_iscdi=true |