A short course of tofacitinib sustains the immunoregulatory effect of CTLA4‐Ig in the presence of inflammatory cytokines and promotes long‐term survival of murine cardiac allografts

Costimulation blockade‐based regimens are a promising strategy for management of transplant recipients. However, maintenance immunosuppression via CTLA4‐Ig monotherapy is characterized by high frequency of rejection episodes. Recent evidence suggests that inflammatory cytokines contribute to allorea...

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Veröffentlicht in:	American journal of transplantation 2021-08, Vol.21 (8), p.2675-2687
Hauptverfasser:	Iglesias, Marcos, Khalifian, Saami, Oh, Byoung C., Zhang, Yichuan, Miller, Devin, Beck, Sarah, Brandacher, Gerald, Raimondi, Giorgio
Format:	Artikel
Sprache:	eng
Schlagworte:	Abatacept - pharmacology Allografts Animals basic (laboratory) research / science CD28 antigen Cell activation Costimulator CTLA-4 Antigen CTLA-4 protein Cytokines cytokines / cytokine receptors Dendritic cells Effector cells Graft rejection Graft Rejection - drug therapy Graft Rejection - prevention & control Graft Survival Heart Transplantation Heart transplants Humans immunobiology Immunoconjugates Immunoglobulins Immunomodulation Immunoregulation immunosuppressant ‐ fusion proteins and monoclonal antibodies: belatacept Immunosuppression immunosuppression / immune modulation Inflammation Ischemia lymphocyte biology: activation Lymphocytes Lymphocytes T Mice Mice, Inbred BALB C Mice, Inbred C57BL Monoclonal antibodies Phenotypes Piperidines Pyrimidines Rodents signaling / signaling pathways: JAK / STAT tolerance: costimulation blockade
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