The many faces of Sox2 function in neural crest development
Neural crest (NC) cells give rise to a wide variety of cell types and tissues, such as neurons and glial cells in the peripheral nervous system. Sox2, which encodes an HMG‐box transcription factor, is known to mediate pluripotency of primordial germ cells and embryonic stem (ES)/induced pluripotent...
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| Veröffentlicht in: | Development, growth & differentiation growth & differentiation, 2021-01, Vol.63 (1), p.93-99 |
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| creator | Wakamatsu, Yoshio Uchikawa, Masanori |
| description | Neural crest (NC) cells give rise to a wide variety of cell types and tissues, such as neurons and glial cells in the peripheral nervous system. Sox2, which encodes an HMG‐box transcription factor, is known to mediate pluripotency of primordial germ cells and embryonic stem (ES)/induced pluripotent stem (iPS) cells, and to regulate central nervous system development. Previous studies have revealed that Sox2 is also an important regulator of NC development. This review summarizes the well‐established inhibitory roles of Sox2 in NC formation and subsequent neuronal differentiation of NC‐derived cells. This review also covers recent studies suggesting additional roles for Sox2 in early NC development, neurogenesis, and glial differentiation of NC‐derived cells.
Previous studies have revealed that Sox2 is an important regulator of neural crest development, and this review article summarizes the well‐established inhibitory roles of Sox2 in neural crest formation and neuronal differentiation of neural‐crest‐derived cells. This review also covers recent studies suggesting additional roles of Sox2 in early NC development, neurogenesis, and glial differentiation of NC‐derived cells. |
| doi_str_mv | 10.1111/dgd.12705 |
| format | Article |
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Previous studies have revealed that Sox2 is an important regulator of neural crest development, and this review article summarizes the well‐established inhibitory roles of Sox2 in neural crest formation and neuronal differentiation of neural‐crest‐derived cells. This review also covers recent studies suggesting additional roles of Sox2 in early NC development, neurogenesis, and glial differentiation of NC‐derived cells.</description><identifier>ISSN: 0012-1592</identifier><identifier>EISSN: 1440-169X</identifier><identifier>DOI: 10.1111/dgd.12705</identifier><identifier>PMID: 33326593</identifier><language>eng</language><publisher>Japan: Wiley Subscription Services, Inc</publisher><subject>Cell differentiation ; Central nervous system ; dorsal root ganglia ; epithelial–mesenchymal transition ; Germ cells ; Glial cells ; Nervous system ; Neural crest ; Neurogenesis ; Neuronal-glial interactions ; Notch ; N‐cadherin ; Pax7 ; Pluripotency ; Schwann cell ; sensory neuron ; Sox10 ; Sox2</subject><ispartof>Development, growth & differentiation, 2021-01, Vol.63 (1), p.93-99</ispartof><rights>2020 Japanese Society of Developmental Biologists</rights><rights>2020 Japanese Society of Developmental Biologists.</rights><rights>2021 Japanese Society of Developmental Biologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4435-d39e63a5b3f68a3d84799334f824d66bc5d2bb36fdb2ee81d4478970d92aaba93</citedby><cites>FETCH-LOGICAL-c4435-d39e63a5b3f68a3d84799334f824d66bc5d2bb36fdb2ee81d4478970d92aaba93</cites><orcidid>0000-0002-8014-5749 ; 0000-0002-5595-4157</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fdgd.12705$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fdgd.12705$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27903,27904,45553,45554,46388,46812</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33326593$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wakamatsu, Yoshio</creatorcontrib><creatorcontrib>Uchikawa, Masanori</creatorcontrib><title>The many faces of Sox2 function in neural crest development</title><title>Development, growth & differentiation</title><addtitle>Dev Growth Differ</addtitle><description>Neural crest (NC) cells give rise to a wide variety of cell types and tissues, such as neurons and glial cells in the peripheral nervous system. Sox2, which encodes an HMG‐box transcription factor, is known to mediate pluripotency of primordial germ cells and embryonic stem (ES)/induced pluripotent stem (iPS) cells, and to regulate central nervous system development. Previous studies have revealed that Sox2 is also an important regulator of NC development. This review summarizes the well‐established inhibitory roles of Sox2 in NC formation and subsequent neuronal differentiation of NC‐derived cells. This review also covers recent studies suggesting additional roles for Sox2 in early NC development, neurogenesis, and glial differentiation of NC‐derived cells.
Previous studies have revealed that Sox2 is an important regulator of neural crest development, and this review article summarizes the well‐established inhibitory roles of Sox2 in neural crest formation and neuronal differentiation of neural‐crest‐derived cells. This review also covers recent studies suggesting additional roles of Sox2 in early NC development, neurogenesis, and glial differentiation of NC‐derived cells.</description><subject>Cell differentiation</subject><subject>Central nervous system</subject><subject>dorsal root ganglia</subject><subject>epithelial–mesenchymal transition</subject><subject>Germ cells</subject><subject>Glial cells</subject><subject>Nervous system</subject><subject>Neural crest</subject><subject>Neurogenesis</subject><subject>Neuronal-glial interactions</subject><subject>Notch</subject><subject>N‐cadherin</subject><subject>Pax7</subject><subject>Pluripotency</subject><subject>Schwann cell</subject><subject>sensory neuron</subject><subject>Sox10</subject><subject>Sox2</subject><issn>0012-1592</issn><issn>1440-169X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp10E9LwzAYBvAgipvTg19AAl700C3_2jR4kk2nIHhwgreQNol2tMlsVnXf3minB8H38l5-78PLA8AxRmMcZ6Kf9RgTjtIdMMSMoQRn4mkXDBHCJMGpIANwEMISIcQYJvtgQCklWSroEFwsXgxslNtAq0oToLfwwX8QaDtXrivvYOWgM12rali2JqyhNm-m9qvGuPUh2LOqDuZou0fg8fpqMb1J7u7nt9PLu6RkjKaJpsJkVKUFtVmuqM4ZF4JSZnPCdJYVZapJUdDM6oIYk2PNGM8FR1oQpQol6Aic9bmr1r928QnZVKE0da2c8V2QhHEUDzjmkZ7-oUvftS5-F5XggnHK8qjOe1W2PoTWWLlqq0a1G4mR_GpUxkbld6PRnmwTu6Ix-lf-VBjBpAfvVW02_yfJ2XzWR34CQ0B9YQ</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Wakamatsu, Yoshio</creator><creator>Uchikawa, Masanori</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8014-5749</orcidid><orcidid>https://orcid.org/0000-0002-5595-4157</orcidid></search><sort><creationdate>202101</creationdate><title>The many faces of Sox2 function in neural crest development</title><author>Wakamatsu, Yoshio ; Uchikawa, Masanori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4435-d39e63a5b3f68a3d84799334f824d66bc5d2bb36fdb2ee81d4478970d92aaba93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cell differentiation</topic><topic>Central nervous system</topic><topic>dorsal root ganglia</topic><topic>epithelial–mesenchymal transition</topic><topic>Germ cells</topic><topic>Glial cells</topic><topic>Nervous system</topic><topic>Neural crest</topic><topic>Neurogenesis</topic><topic>Neuronal-glial interactions</topic><topic>Notch</topic><topic>N‐cadherin</topic><topic>Pax7</topic><topic>Pluripotency</topic><topic>Schwann cell</topic><topic>sensory neuron</topic><topic>Sox10</topic><topic>Sox2</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wakamatsu, Yoshio</creatorcontrib><creatorcontrib>Uchikawa, Masanori</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Development, growth & differentiation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wakamatsu, Yoshio</au><au>Uchikawa, Masanori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The many faces of Sox2 function in neural crest development</atitle><jtitle>Development, growth & differentiation</jtitle><addtitle>Dev Growth Differ</addtitle><date>2021-01</date><risdate>2021</risdate><volume>63</volume><issue>1</issue><spage>93</spage><epage>99</epage><pages>93-99</pages><issn>0012-1592</issn><eissn>1440-169X</eissn><abstract>Neural crest (NC) cells give rise to a wide variety of cell types and tissues, such as neurons and glial cells in the peripheral nervous system. Sox2, which encodes an HMG‐box transcription factor, is known to mediate pluripotency of primordial germ cells and embryonic stem (ES)/induced pluripotent stem (iPS) cells, and to regulate central nervous system development. Previous studies have revealed that Sox2 is also an important regulator of NC development. This review summarizes the well‐established inhibitory roles of Sox2 in NC formation and subsequent neuronal differentiation of NC‐derived cells. This review also covers recent studies suggesting additional roles for Sox2 in early NC development, neurogenesis, and glial differentiation of NC‐derived cells.
Previous studies have revealed that Sox2 is an important regulator of neural crest development, and this review article summarizes the well‐established inhibitory roles of Sox2 in neural crest formation and neuronal differentiation of neural‐crest‐derived cells. This review also covers recent studies suggesting additional roles of Sox2 in early NC development, neurogenesis, and glial differentiation of NC‐derived cells.</abstract><cop>Japan</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33326593</pmid><doi>10.1111/dgd.12705</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-8014-5749</orcidid><orcidid>https://orcid.org/0000-0002-5595-4157</orcidid></addata></record> |
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| ispartof | Development, growth & differentiation, 2021-01, Vol.63 (1), p.93-99 |
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| language | eng |
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| source | Wiley-Blackwell Journals; Wiley Online Library Free Content; Freely Accessible Japanese Titles; EZB Electronic Journals Library |
| subjects | Cell differentiation Central nervous system dorsal root ganglia epithelial–mesenchymal transition Germ cells Glial cells Nervous system Neural crest Neurogenesis Neuronal-glial interactions Notch N‐cadherin Pax7 Pluripotency Schwann cell sensory neuron Sox10 Sox2 |
| title | The many faces of Sox2 function in neural crest development |
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