STK11 /LKB1 Mutations in NSCLC Are Associated with KEAP1/NRF2-Dependent Radiotherapy Resistance Targetable by Glutaminase Inhibition

Radiotherapy with or without chemotherapy is a mainstay of treatment for locally advanced non-small cell lung cancer (NSCLC), but no predictive markers are currently available to select patients who will benefit from these therapies. In this study, we investigated the association between alterations...

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Veröffentlicht in:	Clinical cancer research 2021-03, Vol.27 (6), p.1720-1733
Hauptverfasser:	Sitthideatphaiboon, Piyada, Galan-Cobo, Ana, Negrao, Marcelo V, Qu, Xiao, Poteete, Alissa, Zhang, Fahao, Liu, Diane D, Lewis, Whitney E, Kemp, Haley N, Lewis, Jeff, Rinsurongkawong, Waree, Giri, Uma, Lee, J Jack, Zhang, Jianjun, Roth, Jack A, Swisher, Stephen, Heymach, John V
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinase Kinases - genetics Animals Apoptosis Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - radiotherapy Cell Proliferation Female Follow-Up Studies Gamma Rays - adverse effects Gene Expression Regulation, Neoplastic Glutaminase - antagonists & inhibitors Humans Kelch-Like ECH-Associated Protein 1 - genetics Kelch-Like ECH-Associated Protein 1 - metabolism Lung Neoplasms - genetics Lung Neoplasms - pathology Lung Neoplasms - radiotherapy Male Mice Mice, Nude Middle Aged Mutation NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Prognosis Radiation Tolerance - drug effects Radiotherapy - adverse effects Retrospective Studies Survival Rate Tumor Cells, Cultured Xenograft Model Antitumor Assays
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