Lactobacillus plantarum Y44 alleviates oxidative stress by regulating gut microbiota and colonic barrier function in Balb/C mice with subcutaneous d-galactose injection
Probiotics have been proved to ameliorate the symptoms of the host induced by oxidative stress. In this study, the protective effects of Lactobacillus plantarum Y44 on Balb/C mice injured by d-galactose (d-gal)-injection were examined. Six weeks of continuous subcutaneous d-gal injection caused live...
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| Veröffentlicht in: | Food & function 2021-01, Vol.12 (1), p.373-386 |
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| creator | Gao, Yuan Liu, Yujun Ma, Fenglian Sun, Mengying Song, Yinglong Xu, Dongxue Mu, Guangqing Tuo, Yanfeng |
| description | Probiotics have been proved to ameliorate the symptoms of the host induced by oxidative stress. In this study, the protective effects of Lactobacillus plantarum Y44 on Balb/C mice injured by d-galactose (d-gal)-injection were examined. Six weeks of continuous subcutaneous d-gal injection caused liver and colon injury of the Balb/C mice. L. plantarum Y44 administration significantly reversed the injury by modulating hepatic protein expressions related to the Nrf-2/Keap-1 pathway, and enhancing expressions of colonic tight junction proteins. L. plantarum Y44 administration restored the d-gal injection-induced gut microbiota imbalance by manipulating the ratio of Firmicutes/Bacteroidetes (F/B) and Proteobacteria relative abundance at the phylum level, and manipulating relative abundances of Lactobacillaceae, Muribaculaceae, Ruminococcaceae, Desulfovibrionaceae, and Prevotellaceae at the family level. Moreover, the d-gal injection-induced glycerophospholipid metabolism disorder was ameliorated, evidenced by the decline of phosphatidyl ethanolamine (PE), phosphatidylcholine (PC), phosphatidyl serine (PS), and lysophosphatidyl choline (LysoPC) levels in the serum of the mice after the L. plantarum Y44 administration. Spearman correlation analysis revealed a significant correlation between changes in gut microbiota composition, glycerophospholipid levels, and oxidative stress-related indicators. In summary, L. plantarum Y44 administration ameliorated d-gal injection-induced oxidative stress in Balb/C mice by manipulating gut microbiota and intestinal barrier function, and further influenced the glycerophospholipid metabolism and hepatic Nrf-2/Keap-1 pathway-related protein expressions. |
| doi_str_mv | 10.1039/d0fo02794d |
| format | Article |
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In this study, the protective effects of Lactobacillus plantarum Y44 on Balb/C mice injured by d-galactose (d-gal)-injection were examined. Six weeks of continuous subcutaneous d-gal injection caused liver and colon injury of the Balb/C mice. L. plantarum Y44 administration significantly reversed the injury by modulating hepatic protein expressions related to the Nrf-2/Keap-1 pathway, and enhancing expressions of colonic tight junction proteins. L. plantarum Y44 administration restored the d-gal injection-induced gut microbiota imbalance by manipulating the ratio of Firmicutes/Bacteroidetes (F/B) and Proteobacteria relative abundance at the phylum level, and manipulating relative abundances of Lactobacillaceae, Muribaculaceae, Ruminococcaceae, Desulfovibrionaceae, and Prevotellaceae at the family level. Moreover, the d-gal injection-induced glycerophospholipid metabolism disorder was ameliorated, evidenced by the decline of phosphatidyl ethanolamine (PE), phosphatidylcholine (PC), phosphatidyl serine (PS), and lysophosphatidyl choline (LysoPC) levels in the serum of the mice after the L. plantarum Y44 administration. Spearman correlation analysis revealed a significant correlation between changes in gut microbiota composition, glycerophospholipid levels, and oxidative stress-related indicators. In summary, L. plantarum Y44 administration ameliorated d-gal injection-induced oxidative stress in Balb/C mice by manipulating gut microbiota and intestinal barrier function, and further influenced the glycerophospholipid metabolism and hepatic Nrf-2/Keap-1 pathway-related protein expressions.</description><identifier>ISSN: 2042-6496</identifier><identifier>EISSN: 2042-650X</identifier><identifier>DOI: 10.1039/d0fo02794d</identifier><identifier>PMID: 33325942</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Abundance ; Choline ; Colon ; Correlation analysis ; D-Galactose ; Digestive system ; Ethanolamine ; GA-binding protein ; Galactose ; Gastrointestinal tract ; Injection ; Injuries ; Intestinal microflora ; Intestine ; Lactobacilli ; Lactobacillus plantarum ; Lecithin ; Liver ; Metabolism ; Microbiota ; Oxidative stress ; Phosphatidylcholine ; Probiotics ; Protein turnover ; Proteins ; Relative abundance ; Serine</subject><ispartof>Food & function, 2021-01, Vol.12 (1), p.373-386</ispartof><rights>Copyright Royal Society of Chemistry 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-bdfb8fe63df4ef17215114f23b6beca7847c9dc0b12a715f90371428bf5ba60c3</citedby><cites>FETCH-LOGICAL-c356t-bdfb8fe63df4ef17215114f23b6beca7847c9dc0b12a715f90371428bf5ba60c3</cites><orcidid>0000-0003-2874-4354 ; 0000-0002-3931-4272 ; 0000-0001-9356-753X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33325942$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gao, Yuan</creatorcontrib><creatorcontrib>Liu, Yujun</creatorcontrib><creatorcontrib>Ma, Fenglian</creatorcontrib><creatorcontrib>Sun, Mengying</creatorcontrib><creatorcontrib>Song, Yinglong</creatorcontrib><creatorcontrib>Xu, Dongxue</creatorcontrib><creatorcontrib>Mu, Guangqing</creatorcontrib><creatorcontrib>Tuo, Yanfeng</creatorcontrib><title>Lactobacillus plantarum Y44 alleviates oxidative stress by regulating gut microbiota and colonic barrier function in Balb/C mice with subcutaneous d-galactose injection</title><title>Food & function</title><addtitle>Food Funct</addtitle><description>Probiotics have been proved to ameliorate the symptoms of the host induced by oxidative stress. In this study, the protective effects of Lactobacillus plantarum Y44 on Balb/C mice injured by d-galactose (d-gal)-injection were examined. Six weeks of continuous subcutaneous d-gal injection caused liver and colon injury of the Balb/C mice. L. plantarum Y44 administration significantly reversed the injury by modulating hepatic protein expressions related to the Nrf-2/Keap-1 pathway, and enhancing expressions of colonic tight junction proteins. L. plantarum Y44 administration restored the d-gal injection-induced gut microbiota imbalance by manipulating the ratio of Firmicutes/Bacteroidetes (F/B) and Proteobacteria relative abundance at the phylum level, and manipulating relative abundances of Lactobacillaceae, Muribaculaceae, Ruminococcaceae, Desulfovibrionaceae, and Prevotellaceae at the family level. Moreover, the d-gal injection-induced glycerophospholipid metabolism disorder was ameliorated, evidenced by the decline of phosphatidyl ethanolamine (PE), phosphatidylcholine (PC), phosphatidyl serine (PS), and lysophosphatidyl choline (LysoPC) levels in the serum of the mice after the L. plantarum Y44 administration. Spearman correlation analysis revealed a significant correlation between changes in gut microbiota composition, glycerophospholipid levels, and oxidative stress-related indicators. In summary, L. plantarum Y44 administration ameliorated d-gal injection-induced oxidative stress in Balb/C mice by manipulating gut microbiota and intestinal barrier function, and further influenced the glycerophospholipid metabolism and hepatic Nrf-2/Keap-1 pathway-related protein expressions.</description><subject>Abundance</subject><subject>Choline</subject><subject>Colon</subject><subject>Correlation analysis</subject><subject>D-Galactose</subject><subject>Digestive system</subject><subject>Ethanolamine</subject><subject>GA-binding protein</subject><subject>Galactose</subject><subject>Gastrointestinal tract</subject><subject>Injection</subject><subject>Injuries</subject><subject>Intestinal microflora</subject><subject>Intestine</subject><subject>Lactobacilli</subject><subject>Lactobacillus plantarum</subject><subject>Lecithin</subject><subject>Liver</subject><subject>Metabolism</subject><subject>Microbiota</subject><subject>Oxidative stress</subject><subject>Phosphatidylcholine</subject><subject>Probiotics</subject><subject>Protein turnover</subject><subject>Proteins</subject><subject>Relative abundance</subject><subject>Serine</subject><issn>2042-6496</issn><issn>2042-650X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpdkctqFEEUhgsxmBCz8QGkwI0IberWXd1LnRgVBrJJIK6auo41VFeNdUnMG_mY1mQSF57NORy-__BzfgDeYPQRIzqda2QjInxi-gU4IYiRbujR7cvnmU3DMTjLeYta0Wkap_EVOKaUkn5i5AT8WQtVohTKeV8z3HkRikh1gT8Yg8J7c-dEMRnG306L4u4MzCWZnKF8gMlsqm_LsIGbWuDiVIrSxSKgCBqq6GNwCkqRkjMJ2hpUcTFAF-Bn4eX5aq8w8N6VnzBXqWoRwcRmQncb4fe2smnw1jzKXoMjK3w2Z0_9FNxcfrlefevWV1-_rz6tO0X7oXRSWzlaM1BtmbGYE9xjzCyhcpBGCT4yriatkMREcNzbCVGOGRml7aUYkKKn4P3h7i7FX9XkMi8uK-P9wdxMGEcDGTnvG_ruP3QbawrN3Z4aBzxyhhv14UC17-ScjJ13yS0iPcwYzfsI5wt0efUY4UWD3z6drHIx-h_6HBj9CzbhmhI</recordid><startdate>20210107</startdate><enddate>20210107</enddate><creator>Gao, Yuan</creator><creator>Liu, Yujun</creator><creator>Ma, Fenglian</creator><creator>Sun, Mengying</creator><creator>Song, Yinglong</creator><creator>Xu, Dongxue</creator><creator>Mu, Guangqing</creator><creator>Tuo, Yanfeng</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2874-4354</orcidid><orcidid>https://orcid.org/0000-0002-3931-4272</orcidid><orcidid>https://orcid.org/0000-0001-9356-753X</orcidid></search><sort><creationdate>20210107</creationdate><title>Lactobacillus plantarum Y44 alleviates oxidative stress by regulating gut microbiota and colonic barrier function in Balb/C mice with subcutaneous d-galactose injection</title><author>Gao, Yuan ; Liu, Yujun ; Ma, Fenglian ; Sun, Mengying ; Song, Yinglong ; Xu, Dongxue ; Mu, Guangqing ; Tuo, Yanfeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-bdfb8fe63df4ef17215114f23b6beca7847c9dc0b12a715f90371428bf5ba60c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Abundance</topic><topic>Choline</topic><topic>Colon</topic><topic>Correlation analysis</topic><topic>D-Galactose</topic><topic>Digestive system</topic><topic>Ethanolamine</topic><topic>GA-binding protein</topic><topic>Galactose</topic><topic>Gastrointestinal tract</topic><topic>Injection</topic><topic>Injuries</topic><topic>Intestinal microflora</topic><topic>Intestine</topic><topic>Lactobacilli</topic><topic>Lactobacillus plantarum</topic><topic>Lecithin</topic><topic>Liver</topic><topic>Metabolism</topic><topic>Microbiota</topic><topic>Oxidative stress</topic><topic>Phosphatidylcholine</topic><topic>Probiotics</topic><topic>Protein turnover</topic><topic>Proteins</topic><topic>Relative abundance</topic><topic>Serine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gao, Yuan</creatorcontrib><creatorcontrib>Liu, Yujun</creatorcontrib><creatorcontrib>Ma, Fenglian</creatorcontrib><creatorcontrib>Sun, Mengying</creatorcontrib><creatorcontrib>Song, Yinglong</creatorcontrib><creatorcontrib>Xu, Dongxue</creatorcontrib><creatorcontrib>Mu, Guangqing</creatorcontrib><creatorcontrib>Tuo, Yanfeng</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Food & function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gao, Yuan</au><au>Liu, Yujun</au><au>Ma, Fenglian</au><au>Sun, Mengying</au><au>Song, Yinglong</au><au>Xu, Dongxue</au><au>Mu, Guangqing</au><au>Tuo, Yanfeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lactobacillus plantarum Y44 alleviates oxidative stress by regulating gut microbiota and colonic barrier function in Balb/C mice with subcutaneous d-galactose injection</atitle><jtitle>Food & function</jtitle><addtitle>Food Funct</addtitle><date>2021-01-07</date><risdate>2021</risdate><volume>12</volume><issue>1</issue><spage>373</spage><epage>386</epage><pages>373-386</pages><issn>2042-6496</issn><eissn>2042-650X</eissn><abstract>Probiotics have been proved to ameliorate the symptoms of the host induced by oxidative stress. In this study, the protective effects of Lactobacillus plantarum Y44 on Balb/C mice injured by d-galactose (d-gal)-injection were examined. Six weeks of continuous subcutaneous d-gal injection caused liver and colon injury of the Balb/C mice. L. plantarum Y44 administration significantly reversed the injury by modulating hepatic protein expressions related to the Nrf-2/Keap-1 pathway, and enhancing expressions of colonic tight junction proteins. L. plantarum Y44 administration restored the d-gal injection-induced gut microbiota imbalance by manipulating the ratio of Firmicutes/Bacteroidetes (F/B) and Proteobacteria relative abundance at the phylum level, and manipulating relative abundances of Lactobacillaceae, Muribaculaceae, Ruminococcaceae, Desulfovibrionaceae, and Prevotellaceae at the family level. Moreover, the d-gal injection-induced glycerophospholipid metabolism disorder was ameliorated, evidenced by the decline of phosphatidyl ethanolamine (PE), phosphatidylcholine (PC), phosphatidyl serine (PS), and lysophosphatidyl choline (LysoPC) levels in the serum of the mice after the L. plantarum Y44 administration. Spearman correlation analysis revealed a significant correlation between changes in gut microbiota composition, glycerophospholipid levels, and oxidative stress-related indicators. In summary, L. plantarum Y44 administration ameliorated d-gal injection-induced oxidative stress in Balb/C mice by manipulating gut microbiota and intestinal barrier function, and further influenced the glycerophospholipid metabolism and hepatic Nrf-2/Keap-1 pathway-related protein expressions.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>33325942</pmid><doi>10.1039/d0fo02794d</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-2874-4354</orcidid><orcidid>https://orcid.org/0000-0002-3931-4272</orcidid><orcidid>https://orcid.org/0000-0001-9356-753X</orcidid></addata></record> |
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| ispartof | Food & function, 2021-01, Vol.12 (1), p.373-386 |
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| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Abundance Choline Colon Correlation analysis D-Galactose Digestive system Ethanolamine GA-binding protein Galactose Gastrointestinal tract Injection Injuries Intestinal microflora Intestine Lactobacilli Lactobacillus plantarum Lecithin Liver Metabolism Microbiota Oxidative stress Phosphatidylcholine Probiotics Protein turnover Proteins Relative abundance Serine |
| title | Lactobacillus plantarum Y44 alleviates oxidative stress by regulating gut microbiota and colonic barrier function in Balb/C mice with subcutaneous d-galactose injection |
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