Recognition and Removal of Amyloid‐β by a Heteromultivalent Macrocyclic Coassembly: A Potential Strategy for the Treatment of Alzheimer's Disease

The imbalance of amyloid‐β (Aβ) production and clearance causes aggregation of Aβ1‐42 monomers to form fibrils and amyloid plaques, which is an indispensable process in the pathogenesis of Alzheimer's disease (AD), and eventually leads to pathological changes and cognitive impairment. Consequen...

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Veröffentlicht in:	Advanced materials (Weinheim) 2021-01, Vol.33 (4), p.e2006483-n/a
Hauptverfasser:	Wang, Hui, Xu, XinXin, Pan, Yu‐Chen, Yan, YuXing, Hu, Xin‐Yue, Chen, RunWen, Ravoo, Bart Jan, Guo, Dong‐Sheng, Zhang, Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Peptides - chemistry Amyloid beta-Peptides - metabolism amyloid plaques Animals Apoptosis Apoptosis - drug effects Calixarenes Calixarenes - chemistry Cognition Cyclodextrins Cyclodextrins - chemistry Fibrillation heteromultivalent recognition Humans Impairment Macrocyclic Compounds - chemistry Macrocyclic Compounds - pharmacology Materials science Mice Microglia - drug effects Microglia - metabolism Monomers Oxidizing agents Pathogenesis pathological impairment Pathology Peptide Fragments - chemistry Peptide Fragments - metabolism Plaque, Amyloid - drug therapy Plaque, Amyloid - metabolism Recognition Strategy
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