Mandibular-related bone metabolism in orchiectomized rats treated with sex hormones
•Estradiol and testosterone therapies play a role in mandibular bone metabolism.•Testosterone replacement therapy might protect the alveolar bone height.•Estradiol may influence serum levels of ALP in orchiectomized rats.•Sex hormones deficiency exhibits a decrease in mandibular bone mineral density...
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| Veröffentlicht in: | Archives of oral biology 2021-02, Vol.122, p.105000-105000, Article 105000 |
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| container_title | Archives of oral biology |
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| creator | Gomes, Natália Amanda Guarenghi, Gabriel Guidio Valenga, Henrique Meister Warnavin, Stephanie von Stein Cubas Chaves, João Daniel Paganella Cardoso, Anny Caroline Steffens, João Paulo |
| description | •Estradiol and testosterone therapies play a role in mandibular bone metabolism.•Testosterone replacement therapy might protect the alveolar bone height.•Estradiol may influence serum levels of ALP in orchiectomized rats.•Sex hormones deficiency exhibits a decrease in mandibular bone mineral density.
This study aimed to compare the impact of testosterone and estrogen replacement therapy on mandibular bone density and bone-related markers.
Forty male adult rats were randomly allocated to 4 experimental groups (n = 10/group): Sham (Control); Orchiectomy; Orchiectomy plus testosterone replacement; and orchiectomy plus estradiol replacement. Twenty-four days after orchiectomy, the hemi-mandibles were collected and processed for analysis of microhardness in cortical and trabecular bone, radiographic bone density and histomorphometric evaluation. Serum was collected for the analysis of calcium, phosphorus, alkaline phosphatase and magnesium.
The orchiectomy group had the lowest mandibular bone density (p |
| doi_str_mv | 10.1016/j.archoralbio.2020.105000 |
| format | Article |
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This study aimed to compare the impact of testosterone and estrogen replacement therapy on mandibular bone density and bone-related markers.
Forty male adult rats were randomly allocated to 4 experimental groups (n = 10/group): Sham (Control); Orchiectomy; Orchiectomy plus testosterone replacement; and orchiectomy plus estradiol replacement. Twenty-four days after orchiectomy, the hemi-mandibles were collected and processed for analysis of microhardness in cortical and trabecular bone, radiographic bone density and histomorphometric evaluation. Serum was collected for the analysis of calcium, phosphorus, alkaline phosphatase and magnesium.
The orchiectomy group had the lowest mandibular bone density (p < 0.01) and also their serum levels of alkaline phosphatase were higher than all other experimental groups (p < 0.001). Estradiol replacement significantly reduced microhardness when compared to orchiectomy in cortical bone (p < 0.05). Both testosterone and estrogen replacement reverted orchiectomy impact on this parameter (p < 0.01); and decreased alkaline phosphatase to levels comparable to the Sham-Control group. The effect of estrogen was more pronounced than testosterone, and a statistically significant difference was observed between Sham-Control and testosterone replacement (p < 0.05) but not between Sham-Control and estradiol replacement groups.
Our findings demonstrated that both estradiol and testosterone replacement therapies play a role in mandibular bone metabolism, but suggest different pathways.</description><identifier>ISSN: 0003-9969</identifier><identifier>EISSN: 1879-1506</identifier><identifier>DOI: 10.1016/j.archoralbio.2020.105000</identifier><identifier>PMID: 33307323</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Bone Density ; Dentistry ; Estradiol - administration & dosage ; Gonadal Steroid Hormones - administration & dosage ; Male ; Mandible ; Mandible - diagnostic imaging ; Mandible - metabolism ; Orchiectomy ; Osteoporosis ; Rats ; Sex hormones ; Testosterone - administration & dosage</subject><ispartof>Archives of oral biology, 2021-02, Vol.122, p.105000-105000, Article 105000</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-9fdc275b47759c04c434e9f85b1d8c975ef8dd4e1437f9c6ed8b6df3fede4353</citedby><cites>FETCH-LOGICAL-c377t-9fdc275b47759c04c434e9f85b1d8c975ef8dd4e1437f9c6ed8b6df3fede4353</cites><orcidid>0000-0002-6071-553X ; 0000-0003-4050-8151</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0003996920303782$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33307323$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gomes, Natália Amanda</creatorcontrib><creatorcontrib>Guarenghi, Gabriel Guidio</creatorcontrib><creatorcontrib>Valenga, Henrique Meister</creatorcontrib><creatorcontrib>Warnavin, Stephanie von Stein Cubas</creatorcontrib><creatorcontrib>Chaves, João Daniel Paganella</creatorcontrib><creatorcontrib>Cardoso, Anny Caroline</creatorcontrib><creatorcontrib>Steffens, João Paulo</creatorcontrib><title>Mandibular-related bone metabolism in orchiectomized rats treated with sex hormones</title><title>Archives of oral biology</title><addtitle>Arch Oral Biol</addtitle><description>•Estradiol and testosterone therapies play a role in mandibular bone metabolism.•Testosterone replacement therapy might protect the alveolar bone height.•Estradiol may influence serum levels of ALP in orchiectomized rats.•Sex hormones deficiency exhibits a decrease in mandibular bone mineral density.
This study aimed to compare the impact of testosterone and estrogen replacement therapy on mandibular bone density and bone-related markers.
Forty male adult rats were randomly allocated to 4 experimental groups (n = 10/group): Sham (Control); Orchiectomy; Orchiectomy plus testosterone replacement; and orchiectomy plus estradiol replacement. Twenty-four days after orchiectomy, the hemi-mandibles were collected and processed for analysis of microhardness in cortical and trabecular bone, radiographic bone density and histomorphometric evaluation. Serum was collected for the analysis of calcium, phosphorus, alkaline phosphatase and magnesium.
The orchiectomy group had the lowest mandibular bone density (p < 0.01) and also their serum levels of alkaline phosphatase were higher than all other experimental groups (p < 0.001). Estradiol replacement significantly reduced microhardness when compared to orchiectomy in cortical bone (p < 0.05). Both testosterone and estrogen replacement reverted orchiectomy impact on this parameter (p < 0.01); and decreased alkaline phosphatase to levels comparable to the Sham-Control group. The effect of estrogen was more pronounced than testosterone, and a statistically significant difference was observed between Sham-Control and testosterone replacement (p < 0.05) but not between Sham-Control and estradiol replacement groups.
Our findings demonstrated that both estradiol and testosterone replacement therapies play a role in mandibular bone metabolism, but suggest different pathways.</description><subject>Animals</subject><subject>Bone Density</subject><subject>Dentistry</subject><subject>Estradiol - administration & dosage</subject><subject>Gonadal Steroid Hormones - administration & dosage</subject><subject>Male</subject><subject>Mandible</subject><subject>Mandible - diagnostic imaging</subject><subject>Mandible - metabolism</subject><subject>Orchiectomy</subject><subject>Osteoporosis</subject><subject>Rats</subject><subject>Sex hormones</subject><subject>Testosterone - administration & dosage</subject><issn>0003-9969</issn><issn>1879-1506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1PwyAUhonRuDn9C6beedMJpZRyaRa_khkv3D2hcJqxtGVC69evl9lpvPSKcPK8vIcHoQuC5wST4mozV16vnVdNZd08w9luzjDGB2hKSi5SwnBxiKZxQlMhCjFBJyFs4pUVBTlGE0op5jSjU_T8qDpjq6FRPvXQqB5MUrkOkhZ6VbnGhjaxXeJinwXdu9Z-RsKrPiS9h2_8zfbrJMB7EjdqYzScoqNaNQHO9ucMrW5vVov7dPl097C4Xqaact6nojY646zKOWdC41znNAdRl6wiptSCM6hLY3IgOeW10AWYsipMTWswkFNGZ-hyfHbr3csAoZetDRqaRnXghiCznOOsZLQUERUjqr0LwUMtt962yn9IguVOqdzIP0rlTqkclcbs-b5mqFowv8kfhxFYjADEv75a8DJoC50GY31UJo2z_6j5Aomhjz0</recordid><startdate>202102</startdate><enddate>202102</enddate><creator>Gomes, Natália Amanda</creator><creator>Guarenghi, Gabriel Guidio</creator><creator>Valenga, Henrique Meister</creator><creator>Warnavin, Stephanie von Stein Cubas</creator><creator>Chaves, João Daniel Paganella</creator><creator>Cardoso, Anny Caroline</creator><creator>Steffens, João Paulo</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6071-553X</orcidid><orcidid>https://orcid.org/0000-0003-4050-8151</orcidid></search><sort><creationdate>202102</creationdate><title>Mandibular-related bone metabolism in orchiectomized rats treated with sex hormones</title><author>Gomes, Natália Amanda ; 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This study aimed to compare the impact of testosterone and estrogen replacement therapy on mandibular bone density and bone-related markers.
Forty male adult rats were randomly allocated to 4 experimental groups (n = 10/group): Sham (Control); Orchiectomy; Orchiectomy plus testosterone replacement; and orchiectomy plus estradiol replacement. Twenty-four days after orchiectomy, the hemi-mandibles were collected and processed for analysis of microhardness in cortical and trabecular bone, radiographic bone density and histomorphometric evaluation. Serum was collected for the analysis of calcium, phosphorus, alkaline phosphatase and magnesium.
The orchiectomy group had the lowest mandibular bone density (p < 0.01) and also their serum levels of alkaline phosphatase were higher than all other experimental groups (p < 0.001). Estradiol replacement significantly reduced microhardness when compared to orchiectomy in cortical bone (p < 0.05). Both testosterone and estrogen replacement reverted orchiectomy impact on this parameter (p < 0.01); and decreased alkaline phosphatase to levels comparable to the Sham-Control group. The effect of estrogen was more pronounced than testosterone, and a statistically significant difference was observed between Sham-Control and testosterone replacement (p < 0.05) but not between Sham-Control and estradiol replacement groups.
Our findings demonstrated that both estradiol and testosterone replacement therapies play a role in mandibular bone metabolism, but suggest different pathways.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>33307323</pmid><doi>10.1016/j.archoralbio.2020.105000</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-6071-553X</orcidid><orcidid>https://orcid.org/0000-0003-4050-8151</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Bone Density Dentistry Estradiol - administration & dosage Gonadal Steroid Hormones - administration & dosage Male Mandible Mandible - diagnostic imaging Mandible - metabolism Orchiectomy Osteoporosis Rats Sex hormones Testosterone - administration & dosage |
| title | Mandibular-related bone metabolism in orchiectomized rats treated with sex hormones |
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