Vitreous substitutes: An overview of the properties, importance, and development
Vitreous or vitreous humor is a complex transparent gel that fills the space between the lens and retina of an eye and acts as a transparent medium that allows light to pass through it to reach the photoreceptor layer (retina) of the eye. The vitreous humor is removed in ocular surgery (vitrectomy)...
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| Veröffentlicht in: | Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2021-08, Vol.109 (8), p.1156-1176 |
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| container_title | Journal of biomedical materials research. Part B, Applied biomaterials |
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| creator | Yadav, Indu Purohit, Shiv Dutt Singh, Hemant Bhushan, Sakchi Yadav, Manoj Kumar Velpandian, Thirumurthy Chawla, Rohan Hazra, Saugata Mishra, Narayan Chandra |
| description | Vitreous or vitreous humor is a complex transparent gel that fills the space between the lens and retina of an eye and acts as a transparent medium that allows light to pass through it to reach the photoreceptor layer (retina) of the eye. The vitreous humor is removed in ocular surgery (vitrectomy) for pathologies like retinal detachment, macular hole, diabetes‐related vitreous hemorrhage detachment, and ocular trauma. Since the vitreous is not actively regenerated or replenished, there is a need for a vitreous substitute to fill the vitreous cavity to provide a temporary or permanent tamponade to the retina following some vitreoretinal surgeries. An ideal vitreous substitute could probably be left inside the eye forever. The vitreous humor is transparent, biocompatible, viscoelastic and highly hydrophilic; polymeric hydrogels with these properties can be a potential candidate to be used as vitreous substitutes. To meet the tremendous demand for the vitreous substitute, many scientists all over the world have developed various kinds of vitreous substitutes or tamponade agent. Vitreous substitutes, whatsoever developed till date, are associated with several advantages and disadvantages, and there is no ideal vitreous substitute available till date. This review highlights the polymer‐based vitreous substitutes developed so far, along with their advantages and limitations. The gas‐based and oil‐based substitutes have also been discussed but very briefly. |
| doi_str_mv | 10.1002/jbm.b.34778 |
| format | Article |
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The vitreous humor is removed in ocular surgery (vitrectomy) for pathologies like retinal detachment, macular hole, diabetes‐related vitreous hemorrhage detachment, and ocular trauma. Since the vitreous is not actively regenerated or replenished, there is a need for a vitreous substitute to fill the vitreous cavity to provide a temporary or permanent tamponade to the retina following some vitreoretinal surgeries. An ideal vitreous substitute could probably be left inside the eye forever. The vitreous humor is transparent, biocompatible, viscoelastic and highly hydrophilic; polymeric hydrogels with these properties can be a potential candidate to be used as vitreous substitutes. To meet the tremendous demand for the vitreous substitute, many scientists all over the world have developed various kinds of vitreous substitutes or tamponade agent. Vitreous substitutes, whatsoever developed till date, are associated with several advantages and disadvantages, and there is no ideal vitreous substitute available till date. This review highlights the polymer‐based vitreous substitutes developed so far, along with their advantages and limitations. The gas‐based and oil‐based substitutes have also been discussed but very briefly.</description><identifier>ISSN: 1552-4973</identifier><identifier>EISSN: 1552-4981</identifier><identifier>DOI: 10.1002/jbm.b.34778</identifier><identifier>PMID: 33319466</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Biocompatibility ; Biocompatible Materials - chemistry ; Biocompatible Materials - therapeutic use ; Biomedical materials ; Diabetes mellitus ; Eye ; Eye Diseases - surgery ; Eye lens ; Hemorrhage ; Humans ; hydrogel ; Hydrogels ; Hydrogels - chemistry ; Hydrogels - therapeutic use ; Materials research ; Materials science ; Polymers ; Retina ; retinal detachment ; Substitutes ; Surgery ; Tamponade ; tamponade agent ; Trauma ; Viscoelasticity ; Vitrectomy ; Vitreous Body - surgery ; Vitreous humor ; Vitreous humour ; vitreous substitutes</subject><ispartof>Journal of biomedical materials research. Part B, Applied biomaterials, 2021-08, Vol.109 (8), p.1156-1176</ispartof><rights>2020 Wiley Periodicals LLC.</rights><rights>2021 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4238-987a8c49a849a2a6134aaf0753107de955880f7ece30341a887e8eeed320292c3</citedby><cites>FETCH-LOGICAL-c4238-987a8c49a849a2a6134aaf0753107de955880f7ece30341a887e8eeed320292c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbm.b.34778$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbm.b.34778$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33319466$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yadav, Indu</creatorcontrib><creatorcontrib>Purohit, Shiv Dutt</creatorcontrib><creatorcontrib>Singh, Hemant</creatorcontrib><creatorcontrib>Bhushan, Sakchi</creatorcontrib><creatorcontrib>Yadav, Manoj Kumar</creatorcontrib><creatorcontrib>Velpandian, Thirumurthy</creatorcontrib><creatorcontrib>Chawla, Rohan</creatorcontrib><creatorcontrib>Hazra, Saugata</creatorcontrib><creatorcontrib>Mishra, Narayan Chandra</creatorcontrib><title>Vitreous substitutes: An overview of the properties, importance, and development</title><title>Journal of biomedical materials research. Part B, Applied biomaterials</title><addtitle>J Biomed Mater Res B Appl Biomater</addtitle><description>Vitreous or vitreous humor is a complex transparent gel that fills the space between the lens and retina of an eye and acts as a transparent medium that allows light to pass through it to reach the photoreceptor layer (retina) of the eye. The vitreous humor is removed in ocular surgery (vitrectomy) for pathologies like retinal detachment, macular hole, diabetes‐related vitreous hemorrhage detachment, and ocular trauma. Since the vitreous is not actively regenerated or replenished, there is a need for a vitreous substitute to fill the vitreous cavity to provide a temporary or permanent tamponade to the retina following some vitreoretinal surgeries. An ideal vitreous substitute could probably be left inside the eye forever. The vitreous humor is transparent, biocompatible, viscoelastic and highly hydrophilic; polymeric hydrogels with these properties can be a potential candidate to be used as vitreous substitutes. To meet the tremendous demand for the vitreous substitute, many scientists all over the world have developed various kinds of vitreous substitutes or tamponade agent. Vitreous substitutes, whatsoever developed till date, are associated with several advantages and disadvantages, and there is no ideal vitreous substitute available till date. This review highlights the polymer‐based vitreous substitutes developed so far, along with their advantages and limitations. 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An ideal vitreous substitute could probably be left inside the eye forever. The vitreous humor is transparent, biocompatible, viscoelastic and highly hydrophilic; polymeric hydrogels with these properties can be a potential candidate to be used as vitreous substitutes. To meet the tremendous demand for the vitreous substitute, many scientists all over the world have developed various kinds of vitreous substitutes or tamponade agent. Vitreous substitutes, whatsoever developed till date, are associated with several advantages and disadvantages, and there is no ideal vitreous substitute available till date. This review highlights the polymer‐based vitreous substitutes developed so far, along with their advantages and limitations. The gas‐based and oil‐based substitutes have also been discussed but very briefly.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>33319466</pmid><doi>10.1002/jbm.b.34778</doi><tpages>21</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Biocompatibility Biocompatible Materials - chemistry Biocompatible Materials - therapeutic use Biomedical materials Diabetes mellitus Eye Eye Diseases - surgery Eye lens Hemorrhage Humans hydrogel Hydrogels Hydrogels - chemistry Hydrogels - therapeutic use Materials research Materials science Polymers Retina retinal detachment Substitutes Surgery Tamponade tamponade agent Trauma Viscoelasticity Vitrectomy Vitreous Body - surgery Vitreous humor Vitreous humour vitreous substitutes |
| title | Vitreous substitutes: An overview of the properties, importance, and development |
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