Accelerating bone healing in vivo by harnessing the age-altered activation of c-Jun N-terminal kinase 3

We have recently demonstrated that c-Jun N-terminal kinase 3 (JNK3) is a key modulator of the enhanced osteogenic potential of stem cells derived from children when compared to those derived from adults. In this study, we formulated a JNK3-activator nanoparticle (JNK3*) that recapitulates the immens...

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Veröffentlicht in:	Biomaterials 2021-01, Vol.268, p.120540-120540, Article 120540
Hauptverfasser:	González-Vázquez, Arlyng, Raftery, Rosanne M., Günbay, Suzan, Chen, Gang, Murray, Dylan J., O'Brien, Fergal J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Bone healing Collagen jnk3 Mechanobiology Mitogen-Activated Protein Kinase 10 - genetics Mitogen-Activated Protein Kinase 10 - metabolism Osteogenesis Rats Scaffold Stem Cells - metabolism Therapeutic Up-Regulation
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