Surgical microwave ablation of otherwise non-resectable colorectal cancer liver metastases: Expanding opportunities for long term survival
Colorectal liver metastases (CRLM) are the most common extra-lymphatic metastases in colorectal cancers, however, only 15–20% of these patients are candidates for resection. We reviewed our institutional experience with 135 surgical ablations for unresectable CRLM. Retrospective review of surgically...
Gespeichert in:
| Veröffentlicht in: | Surgical oncology 2021-03, Vol.36, p.61-64 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 64 |
|---|---|
| container_issue | |
| container_start_page | 61 |
| container_title | Surgical oncology |
| container_volume | 36 |
| creator | McEachron, Kendall R. Ankeny, Jacob S. Robbins, Alexandria Altman, Ariella M. Marmor, Schelomo D'Souza, Donna Schat, Robben Spilseth, Benjamin Jensen, Eric H. |
| description | Colorectal liver metastases (CRLM) are the most common extra-lymphatic metastases in colorectal cancers, however, only 15–20% of these patients are candidates for resection. We reviewed our institutional experience with 135 surgical ablations for unresectable CRLM.
Retrospective review of surgically ablated CRLM from 2009 to 2018. Patient-specific variables were obtained from the medical record. Kaplan-Meier modeling was performed for survival analyses.
We ablated 135 CRLM in 36 patients over 40 procedures. Median age was 52 years and 58% of patients were male. All patients received systemic chemotherapy. The ablation procedure was completed laparoscopically in 68% of procedures. Median number of ablated lesions per patient was 2 (range 1–15). Median maximum diameter of ablated lesions was 1.9 cm (range 0.5–12.2). Median follow up of the study was 28 months. In this time, median disease-free survival was not reached. Of the 135 lesions ablated, the per-lesion recurrence rate was 6/135 (4.4%). Median overall survival was 81 months.
Surgical ablation of CRLM can provide excellent local control and long-term survival outcomes in patients who may otherwise not be candidates for other liver-directed therapies. |
| doi_str_mv | 10.1016/j.suronc.2020.11.016 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2470282199</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0960740420304497</els_id><sourcerecordid>2478243735</sourcerecordid><originalsourceid>FETCH-LOGICAL-c390t-1df853608475dd0decc9e912fefecaa8ab91ffbfcc0dd50e59f895f330de9c883</originalsourceid><addsrcrecordid>eNp9kc2OFCEUhYnROD2jb2AMiRs31fJTP-DCZDKZUZNJXKhrQsNlpFMFJVA1-go-tVR6dOHChEA4fPcC5yD0gpI9JbR_c9znJcVg9oywKtF9FR-hHRWDbDhn5DHaEdmTZmhJe4bOcz4SQvqB0afojHNO-16QHfr1eUl33ugRT96keK9XwPow6uJjwNHhWL5BuvcZcIihSZDBlHoO2MQxpm0zYqODgYRHv9Z5gqJzHZDf4usfsw7Whzsc5zmmsgRfPGTsYqVjlQukCddvrH7V4zP0xOkxw_OH9QJ9vbn-cvWhuf30_uPV5W1juCSlodaJjvdEtENnLbFgjARJmQMHRmuhD5I6d3DGEGs7Ap10QnaO84pKIwS_QK9PfecUvy-Qi5p8NjCOOkBcsmLtQJhgVMqKvvoHPcYlhfq6jRKs5QPvKtWeqGpgzgmcmpOfdPqpKFFbVuqoTlmpLStFqapiLXv50Hw5TGD_Fv0JpwLvTgBUN1YPSWXjoXpt_ea8stH__4bf4OSsAQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2478243735</pqid></control><display><type>article</type><title>Surgical microwave ablation of otherwise non-resectable colorectal cancer liver metastases: Expanding opportunities for long term survival</title><source>Access via ScienceDirect (Elsevier)</source><creator>McEachron, Kendall R. ; Ankeny, Jacob S. ; Robbins, Alexandria ; Altman, Ariella M. ; Marmor, Schelomo ; D'Souza, Donna ; Schat, Robben ; Spilseth, Benjamin ; Jensen, Eric H.</creator><creatorcontrib>McEachron, Kendall R. ; Ankeny, Jacob S. ; Robbins, Alexandria ; Altman, Ariella M. ; Marmor, Schelomo ; D'Souza, Donna ; Schat, Robben ; Spilseth, Benjamin ; Jensen, Eric H.</creatorcontrib><description>Colorectal liver metastases (CRLM) are the most common extra-lymphatic metastases in colorectal cancers, however, only 15–20% of these patients are candidates for resection. We reviewed our institutional experience with 135 surgical ablations for unresectable CRLM.
Retrospective review of surgically ablated CRLM from 2009 to 2018. Patient-specific variables were obtained from the medical record. Kaplan-Meier modeling was performed for survival analyses.
We ablated 135 CRLM in 36 patients over 40 procedures. Median age was 52 years and 58% of patients were male. All patients received systemic chemotherapy. The ablation procedure was completed laparoscopically in 68% of procedures. Median number of ablated lesions per patient was 2 (range 1–15). Median maximum diameter of ablated lesions was 1.9 cm (range 0.5–12.2). Median follow up of the study was 28 months. In this time, median disease-free survival was not reached. Of the 135 lesions ablated, the per-lesion recurrence rate was 6/135 (4.4%). Median overall survival was 81 months.
Surgical ablation of CRLM can provide excellent local control and long-term survival outcomes in patients who may otherwise not be candidates for other liver-directed therapies.</description><identifier>ISSN: 0960-7404</identifier><identifier>EISSN: 1879-3320</identifier><identifier>DOI: 10.1016/j.suronc.2020.11.016</identifier><identifier>PMID: 33316680</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Ablation ; Cancer ; Cancer therapies ; Catheters ; Chemotherapy ; Colorectal cancer ; Colorectal carcinoma ; Laparoscopy ; Lesions ; Liver ; Liver cancer ; Metastases ; Metastasis ; Microwave ablation ; Patients ; Surgical outcomes ; Survival ; Ultrasonic imaging</subject><ispartof>Surgical oncology, 2021-03, Vol.36, p.61-64</ispartof><rights>2020</rights><rights>Copyright © 2020. Published by Elsevier Ltd.</rights><rights>Copyright Elsevier Limited Mar 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-1df853608475dd0decc9e912fefecaa8ab91ffbfcc0dd50e59f895f330de9c883</citedby><cites>FETCH-LOGICAL-c390t-1df853608475dd0decc9e912fefecaa8ab91ffbfcc0dd50e59f895f330de9c883</cites><orcidid>0000-0002-2598-0549 ; 0000-0003-0225-9318 ; 0000-0003-2668-3287 ; 0000-0002-8330-3394</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.suronc.2020.11.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33316680$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McEachron, Kendall R.</creatorcontrib><creatorcontrib>Ankeny, Jacob S.</creatorcontrib><creatorcontrib>Robbins, Alexandria</creatorcontrib><creatorcontrib>Altman, Ariella M.</creatorcontrib><creatorcontrib>Marmor, Schelomo</creatorcontrib><creatorcontrib>D'Souza, Donna</creatorcontrib><creatorcontrib>Schat, Robben</creatorcontrib><creatorcontrib>Spilseth, Benjamin</creatorcontrib><creatorcontrib>Jensen, Eric H.</creatorcontrib><title>Surgical microwave ablation of otherwise non-resectable colorectal cancer liver metastases: Expanding opportunities for long term survival</title><title>Surgical oncology</title><addtitle>Surg Oncol</addtitle><description>Colorectal liver metastases (CRLM) are the most common extra-lymphatic metastases in colorectal cancers, however, only 15–20% of these patients are candidates for resection. We reviewed our institutional experience with 135 surgical ablations for unresectable CRLM.
Retrospective review of surgically ablated CRLM from 2009 to 2018. Patient-specific variables were obtained from the medical record. Kaplan-Meier modeling was performed for survival analyses.
We ablated 135 CRLM in 36 patients over 40 procedures. Median age was 52 years and 58% of patients were male. All patients received systemic chemotherapy. The ablation procedure was completed laparoscopically in 68% of procedures. Median number of ablated lesions per patient was 2 (range 1–15). Median maximum diameter of ablated lesions was 1.9 cm (range 0.5–12.2). Median follow up of the study was 28 months. In this time, median disease-free survival was not reached. Of the 135 lesions ablated, the per-lesion recurrence rate was 6/135 (4.4%). Median overall survival was 81 months.
Surgical ablation of CRLM can provide excellent local control and long-term survival outcomes in patients who may otherwise not be candidates for other liver-directed therapies.</description><subject>Ablation</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Catheters</subject><subject>Chemotherapy</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Laparoscopy</subject><subject>Lesions</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Microwave ablation</subject><subject>Patients</subject><subject>Surgical outcomes</subject><subject>Survival</subject><subject>Ultrasonic imaging</subject><issn>0960-7404</issn><issn>1879-3320</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kc2OFCEUhYnROD2jb2AMiRs31fJTP-DCZDKZUZNJXKhrQsNlpFMFJVA1-go-tVR6dOHChEA4fPcC5yD0gpI9JbR_c9znJcVg9oywKtF9FR-hHRWDbDhn5DHaEdmTZmhJe4bOcz4SQvqB0afojHNO-16QHfr1eUl33ugRT96keK9XwPow6uJjwNHhWL5BuvcZcIihSZDBlHoO2MQxpm0zYqODgYRHv9Z5gqJzHZDf4usfsw7Whzsc5zmmsgRfPGTsYqVjlQukCddvrH7V4zP0xOkxw_OH9QJ9vbn-cvWhuf30_uPV5W1juCSlodaJjvdEtENnLbFgjARJmQMHRmuhD5I6d3DGEGs7Ap10QnaO84pKIwS_QK9PfecUvy-Qi5p8NjCOOkBcsmLtQJhgVMqKvvoHPcYlhfq6jRKs5QPvKtWeqGpgzgmcmpOfdPqpKFFbVuqoTlmpLStFqapiLXv50Hw5TGD_Fv0JpwLvTgBUN1YPSWXjoXpt_ea8stH__4bf4OSsAQ</recordid><startdate>202103</startdate><enddate>202103</enddate><creator>McEachron, Kendall R.</creator><creator>Ankeny, Jacob S.</creator><creator>Robbins, Alexandria</creator><creator>Altman, Ariella M.</creator><creator>Marmor, Schelomo</creator><creator>D'Souza, Donna</creator><creator>Schat, Robben</creator><creator>Spilseth, Benjamin</creator><creator>Jensen, Eric H.</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2598-0549</orcidid><orcidid>https://orcid.org/0000-0003-0225-9318</orcidid><orcidid>https://orcid.org/0000-0003-2668-3287</orcidid><orcidid>https://orcid.org/0000-0002-8330-3394</orcidid></search><sort><creationdate>202103</creationdate><title>Surgical microwave ablation of otherwise non-resectable colorectal cancer liver metastases: Expanding opportunities for long term survival</title><author>McEachron, Kendall R. ; Ankeny, Jacob S. ; Robbins, Alexandria ; Altman, Ariella M. ; Marmor, Schelomo ; D'Souza, Donna ; Schat, Robben ; Spilseth, Benjamin ; Jensen, Eric H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-1df853608475dd0decc9e912fefecaa8ab91ffbfcc0dd50e59f895f330de9c883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Ablation</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Catheters</topic><topic>Chemotherapy</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Laparoscopy</topic><topic>Lesions</topic><topic>Liver</topic><topic>Liver cancer</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Microwave ablation</topic><topic>Patients</topic><topic>Surgical outcomes</topic><topic>Survival</topic><topic>Ultrasonic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McEachron, Kendall R.</creatorcontrib><creatorcontrib>Ankeny, Jacob S.</creatorcontrib><creatorcontrib>Robbins, Alexandria</creatorcontrib><creatorcontrib>Altman, Ariella M.</creatorcontrib><creatorcontrib>Marmor, Schelomo</creatorcontrib><creatorcontrib>D'Souza, Donna</creatorcontrib><creatorcontrib>Schat, Robben</creatorcontrib><creatorcontrib>Spilseth, Benjamin</creatorcontrib><creatorcontrib>Jensen, Eric H.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McEachron, Kendall R.</au><au>Ankeny, Jacob S.</au><au>Robbins, Alexandria</au><au>Altman, Ariella M.</au><au>Marmor, Schelomo</au><au>D'Souza, Donna</au><au>Schat, Robben</au><au>Spilseth, Benjamin</au><au>Jensen, Eric H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surgical microwave ablation of otherwise non-resectable colorectal cancer liver metastases: Expanding opportunities for long term survival</atitle><jtitle>Surgical oncology</jtitle><addtitle>Surg Oncol</addtitle><date>2021-03</date><risdate>2021</risdate><volume>36</volume><spage>61</spage><epage>64</epage><pages>61-64</pages><issn>0960-7404</issn><eissn>1879-3320</eissn><abstract>Colorectal liver metastases (CRLM) are the most common extra-lymphatic metastases in colorectal cancers, however, only 15–20% of these patients are candidates for resection. We reviewed our institutional experience with 135 surgical ablations for unresectable CRLM.
Retrospective review of surgically ablated CRLM from 2009 to 2018. Patient-specific variables were obtained from the medical record. Kaplan-Meier modeling was performed for survival analyses.
We ablated 135 CRLM in 36 patients over 40 procedures. Median age was 52 years and 58% of patients were male. All patients received systemic chemotherapy. The ablation procedure was completed laparoscopically in 68% of procedures. Median number of ablated lesions per patient was 2 (range 1–15). Median maximum diameter of ablated lesions was 1.9 cm (range 0.5–12.2). Median follow up of the study was 28 months. In this time, median disease-free survival was not reached. Of the 135 lesions ablated, the per-lesion recurrence rate was 6/135 (4.4%). Median overall survival was 81 months.
Surgical ablation of CRLM can provide excellent local control and long-term survival outcomes in patients who may otherwise not be candidates for other liver-directed therapies.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>33316680</pmid><doi>10.1016/j.suronc.2020.11.016</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-2598-0549</orcidid><orcidid>https://orcid.org/0000-0003-0225-9318</orcidid><orcidid>https://orcid.org/0000-0003-2668-3287</orcidid><orcidid>https://orcid.org/0000-0002-8330-3394</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-7404 |
| ispartof | Surgical oncology, 2021-03, Vol.36, p.61-64 |
| issn | 0960-7404 1879-3320 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2470282199 |
| source | Access via ScienceDirect (Elsevier) |
| subjects | Ablation Cancer Cancer therapies Catheters Chemotherapy Colorectal cancer Colorectal carcinoma Laparoscopy Lesions Liver Liver cancer Metastases Metastasis Microwave ablation Patients Surgical outcomes Survival Ultrasonic imaging |
| title | Surgical microwave ablation of otherwise non-resectable colorectal cancer liver metastases: Expanding opportunities for long term survival |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T14%3A08%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Surgical%20microwave%20ablation%20of%20otherwise%20non-resectable%20colorectal%20cancer%20liver%20metastases:%20Expanding%20opportunities%20for%20long%20term%20survival&rft.jtitle=Surgical%20oncology&rft.au=McEachron,%20Kendall%20R.&rft.date=2021-03&rft.volume=36&rft.spage=61&rft.epage=64&rft.pages=61-64&rft.issn=0960-7404&rft.eissn=1879-3320&rft_id=info:doi/10.1016/j.suronc.2020.11.016&rft_dat=%3Cproquest_cross%3E2478243735%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2478243735&rft_id=info:pmid/33316680&rft_els_id=S0960740420304497&rfr_iscdi=true |