Freeze‐Thawing Chitosan/Ions Hydrogel Coated Gauzes Releasing Multiple Metal Ions on Demand for Improved Infected Wound Healing
Imbalance of metal ions in the wound microenvironment is a key factor that leads to delayed wound healing. However, single metal administration to enhance wound repair is usually not enough due to the overlapping nature of the wound healing phases. Herein, a facile freeze‐thawing strategy is develop...
Gespeichert in:
| Veröffentlicht in: | Advanced healthcare materials 2021-03, Vol.10 (6), p.e2001591-n/a |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | n/a |
|---|---|
| container_issue | 6 |
| container_start_page | e2001591 |
| container_title | Advanced healthcare materials |
| container_volume | 10 |
| creator | Xiao, Jian Zhou, Yajiao Ye, Mengqi An, Ying Wang, Kangning Wu, Qiuji Song, Liwan Zhang, Junwen He, Huacheng Zhang, Qianwen Wu, Jiang |
| description | Imbalance of metal ions in the wound microenvironment is a key factor that leads to delayed wound healing. However, single metal administration to enhance wound repair is usually not enough due to the overlapping nature of the wound healing phases. Herein, a facile freeze‐thawing strategy is developed to incorporate chitosan/ions hydrogel into medical gauzes to realize on‐demand release of multiple ions to accelerate wound healing. In vitro study reveals that the gauzes can temporally release multiple metal ions on demand, and the released metal ions show effectiveness in killing bacteria and expediting cell migration. In vivo studies demonstrate that the metal ions loaded gauzes can efficiently enhance infected wound healing. Further histological analysis find that these metal ion‐loaded gauzes accelerate wound healing by promoting granulation formation, collagen deposition and maturation, re‐epithelization, angiogenesis, and inhibiting inflammation via regulating the expression of inflammatory factors (e.g., tumor necrosis factor‐α) and polarization of macrophages. Thus, this novel metal ions delivery system has great potential in infected tissue repair and antibacterial applications.
Chitosan/metal ions hydrogels are coated to medical gauzes through a simple freeze‐thawing strategy to realize on‐demand release of multiple metal ions for improved wound healing by promoting granulation formation, collagen deposition and maturation, re‐epithelization, angiogenesis, and inhibiting inflammation via regulating the expression of inflammatory factors (e.g., tumor necrosis factor‐α ) and polarization of macrophages. |
| doi_str_mv | 10.1002/adhm.202001591 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2470280175</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2470280175</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3731-1f42b22777e58681cf7685c498ac6a3ac37beac10957e6f954623d7d553cdf2c3</originalsourceid><addsrcrecordid>eNqFkctKAzEUhoMoKurWpQTcuGnNZTKZWUq9tGARRHEZ0swZO5KZ1GRGqSt9A5_RJzG1WsGN2SSQ7_84hx-hfUr6lBB2rItp3WeEEUJFTtfQNqM567FU5Ourd0K20F4IDySeVNA0o5toi3POSJJk2-jt3AO8wMfr-81UP1fNPR5Mq9YF3RyPXBPwcF54dw8WD5xuocAXunuBgK_Bgg4LfNzZtppZwGNotcVfIdfgU6h1U-DSeTyqZ949xeyoKcEsJHeui39D0DYadtFGqW2Ave97B92en90Mhr3Lq4vR4OSyZ7jktEfLhE0Yk1KCyOIWppRpJkySZ9qkmutITUAbSnIhIS1zkaSMF7IQgpuiZIbvoKOlN07z2EFoVV0FA9bqBlwXFEskYRmhUkT08A_64DrfxOkUE4RmMqOJjFR_SRnvQvBQqpmvau3nihK16Ect-lGrfmLg4FvbTWooVvhPGxHIl8BzZWH-j06dnA7Hv_JPO_Ccow</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2501878147</pqid></control><display><type>article</type><title>Freeze‐Thawing Chitosan/Ions Hydrogel Coated Gauzes Releasing Multiple Metal Ions on Demand for Improved Infected Wound Healing</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Xiao, Jian ; Zhou, Yajiao ; Ye, Mengqi ; An, Ying ; Wang, Kangning ; Wu, Qiuji ; Song, Liwan ; Zhang, Junwen ; He, Huacheng ; Zhang, Qianwen ; Wu, Jiang</creator><creatorcontrib>Xiao, Jian ; Zhou, Yajiao ; Ye, Mengqi ; An, Ying ; Wang, Kangning ; Wu, Qiuji ; Song, Liwan ; Zhang, Junwen ; He, Huacheng ; Zhang, Qianwen ; Wu, Jiang</creatorcontrib><description>Imbalance of metal ions in the wound microenvironment is a key factor that leads to delayed wound healing. However, single metal administration to enhance wound repair is usually not enough due to the overlapping nature of the wound healing phases. Herein, a facile freeze‐thawing strategy is developed to incorporate chitosan/ions hydrogel into medical gauzes to realize on‐demand release of multiple ions to accelerate wound healing. In vitro study reveals that the gauzes can temporally release multiple metal ions on demand, and the released metal ions show effectiveness in killing bacteria and expediting cell migration. In vivo studies demonstrate that the metal ions loaded gauzes can efficiently enhance infected wound healing. Further histological analysis find that these metal ion‐loaded gauzes accelerate wound healing by promoting granulation formation, collagen deposition and maturation, re‐epithelization, angiogenesis, and inhibiting inflammation via regulating the expression of inflammatory factors (e.g., tumor necrosis factor‐α) and polarization of macrophages. Thus, this novel metal ions delivery system has great potential in infected tissue repair and antibacterial applications.
Chitosan/metal ions hydrogels are coated to medical gauzes through a simple freeze‐thawing strategy to realize on‐demand release of multiple metal ions for improved wound healing by promoting granulation formation, collagen deposition and maturation, re‐epithelization, angiogenesis, and inhibiting inflammation via regulating the expression of inflammatory factors (e.g., tumor necrosis factor‐α ) and polarization of macrophages.</description><identifier>ISSN: 2192-2640</identifier><identifier>EISSN: 2192-2659</identifier><identifier>DOI: 10.1002/adhm.202001591</identifier><identifier>PMID: 33320448</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Angiogenesis ; Antiinfectives and antibacterials ; Bandages ; Cell adhesion & migration ; Chitosan ; Collagen ; controlled release ; Freeze-thawing ; freeze‐thaw ; Granulation ; Hydrogels ; In vivo methods and tests ; Inflammation ; Ions ; Leukocyte migration ; Macrophages ; Melting ; Metal ions ; Microenvironments ; Repair ; Thawing ; Wound Healing</subject><ispartof>Advanced healthcare materials, 2021-03, Vol.10 (6), p.e2001591-n/a</ispartof><rights>2020 Wiley‐VCH GmbH</rights><rights>2020 Wiley-VCH GmbH.</rights><rights>2021 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3731-1f42b22777e58681cf7685c498ac6a3ac37beac10957e6f954623d7d553cdf2c3</citedby><cites>FETCH-LOGICAL-c3731-1f42b22777e58681cf7685c498ac6a3ac37beac10957e6f954623d7d553cdf2c3</cites><orcidid>0000-0001-5177-0636</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fadhm.202001591$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fadhm.202001591$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33320448$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xiao, Jian</creatorcontrib><creatorcontrib>Zhou, Yajiao</creatorcontrib><creatorcontrib>Ye, Mengqi</creatorcontrib><creatorcontrib>An, Ying</creatorcontrib><creatorcontrib>Wang, Kangning</creatorcontrib><creatorcontrib>Wu, Qiuji</creatorcontrib><creatorcontrib>Song, Liwan</creatorcontrib><creatorcontrib>Zhang, Junwen</creatorcontrib><creatorcontrib>He, Huacheng</creatorcontrib><creatorcontrib>Zhang, Qianwen</creatorcontrib><creatorcontrib>Wu, Jiang</creatorcontrib><title>Freeze‐Thawing Chitosan/Ions Hydrogel Coated Gauzes Releasing Multiple Metal Ions on Demand for Improved Infected Wound Healing</title><title>Advanced healthcare materials</title><addtitle>Adv Healthc Mater</addtitle><description>Imbalance of metal ions in the wound microenvironment is a key factor that leads to delayed wound healing. However, single metal administration to enhance wound repair is usually not enough due to the overlapping nature of the wound healing phases. Herein, a facile freeze‐thawing strategy is developed to incorporate chitosan/ions hydrogel into medical gauzes to realize on‐demand release of multiple ions to accelerate wound healing. In vitro study reveals that the gauzes can temporally release multiple metal ions on demand, and the released metal ions show effectiveness in killing bacteria and expediting cell migration. In vivo studies demonstrate that the metal ions loaded gauzes can efficiently enhance infected wound healing. Further histological analysis find that these metal ion‐loaded gauzes accelerate wound healing by promoting granulation formation, collagen deposition and maturation, re‐epithelization, angiogenesis, and inhibiting inflammation via regulating the expression of inflammatory factors (e.g., tumor necrosis factor‐α) and polarization of macrophages. Thus, this novel metal ions delivery system has great potential in infected tissue repair and antibacterial applications.
Chitosan/metal ions hydrogels are coated to medical gauzes through a simple freeze‐thawing strategy to realize on‐demand release of multiple metal ions for improved wound healing by promoting granulation formation, collagen deposition and maturation, re‐epithelization, angiogenesis, and inhibiting inflammation via regulating the expression of inflammatory factors (e.g., tumor necrosis factor‐α ) and polarization of macrophages.</description><subject>Angiogenesis</subject><subject>Antiinfectives and antibacterials</subject><subject>Bandages</subject><subject>Cell adhesion & migration</subject><subject>Chitosan</subject><subject>Collagen</subject><subject>controlled release</subject><subject>Freeze-thawing</subject><subject>freeze‐thaw</subject><subject>Granulation</subject><subject>Hydrogels</subject><subject>In vivo methods and tests</subject><subject>Inflammation</subject><subject>Ions</subject><subject>Leukocyte migration</subject><subject>Macrophages</subject><subject>Melting</subject><subject>Metal ions</subject><subject>Microenvironments</subject><subject>Repair</subject><subject>Thawing</subject><subject>Wound Healing</subject><issn>2192-2640</issn><issn>2192-2659</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctKAzEUhoMoKurWpQTcuGnNZTKZWUq9tGARRHEZ0swZO5KZ1GRGqSt9A5_RJzG1WsGN2SSQ7_84hx-hfUr6lBB2rItp3WeEEUJFTtfQNqM567FU5Ourd0K20F4IDySeVNA0o5toi3POSJJk2-jt3AO8wMfr-81UP1fNPR5Mq9YF3RyPXBPwcF54dw8WD5xuocAXunuBgK_Bgg4LfNzZtppZwGNotcVfIdfgU6h1U-DSeTyqZ949xeyoKcEsJHeui39D0DYadtFGqW2Ave97B92en90Mhr3Lq4vR4OSyZ7jktEfLhE0Yk1KCyOIWppRpJkySZ9qkmutITUAbSnIhIS1zkaSMF7IQgpuiZIbvoKOlN07z2EFoVV0FA9bqBlwXFEskYRmhUkT08A_64DrfxOkUE4RmMqOJjFR_SRnvQvBQqpmvau3nihK16Ect-lGrfmLg4FvbTWooVvhPGxHIl8BzZWH-j06dnA7Hv_JPO_Ccow</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Xiao, Jian</creator><creator>Zhou, Yajiao</creator><creator>Ye, Mengqi</creator><creator>An, Ying</creator><creator>Wang, Kangning</creator><creator>Wu, Qiuji</creator><creator>Song, Liwan</creator><creator>Zhang, Junwen</creator><creator>He, Huacheng</creator><creator>Zhang, Qianwen</creator><creator>Wu, Jiang</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T5</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7TO</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5177-0636</orcidid></search><sort><creationdate>20210301</creationdate><title>Freeze‐Thawing Chitosan/Ions Hydrogel Coated Gauzes Releasing Multiple Metal Ions on Demand for Improved Infected Wound Healing</title><author>Xiao, Jian ; Zhou, Yajiao ; Ye, Mengqi ; An, Ying ; Wang, Kangning ; Wu, Qiuji ; Song, Liwan ; Zhang, Junwen ; He, Huacheng ; Zhang, Qianwen ; Wu, Jiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3731-1f42b22777e58681cf7685c498ac6a3ac37beac10957e6f954623d7d553cdf2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Angiogenesis</topic><topic>Antiinfectives and antibacterials</topic><topic>Bandages</topic><topic>Cell adhesion & migration</topic><topic>Chitosan</topic><topic>Collagen</topic><topic>controlled release</topic><topic>Freeze-thawing</topic><topic>freeze‐thaw</topic><topic>Granulation</topic><topic>Hydrogels</topic><topic>In vivo methods and tests</topic><topic>Inflammation</topic><topic>Ions</topic><topic>Leukocyte migration</topic><topic>Macrophages</topic><topic>Melting</topic><topic>Metal ions</topic><topic>Microenvironments</topic><topic>Repair</topic><topic>Thawing</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xiao, Jian</creatorcontrib><creatorcontrib>Zhou, Yajiao</creatorcontrib><creatorcontrib>Ye, Mengqi</creatorcontrib><creatorcontrib>An, Ying</creatorcontrib><creatorcontrib>Wang, Kangning</creatorcontrib><creatorcontrib>Wu, Qiuji</creatorcontrib><creatorcontrib>Song, Liwan</creatorcontrib><creatorcontrib>Zhang, Junwen</creatorcontrib><creatorcontrib>He, Huacheng</creatorcontrib><creatorcontrib>Zhang, Qianwen</creatorcontrib><creatorcontrib>Wu, Jiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Immunology Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Advanced healthcare materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xiao, Jian</au><au>Zhou, Yajiao</au><au>Ye, Mengqi</au><au>An, Ying</au><au>Wang, Kangning</au><au>Wu, Qiuji</au><au>Song, Liwan</au><au>Zhang, Junwen</au><au>He, Huacheng</au><au>Zhang, Qianwen</au><au>Wu, Jiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Freeze‐Thawing Chitosan/Ions Hydrogel Coated Gauzes Releasing Multiple Metal Ions on Demand for Improved Infected Wound Healing</atitle><jtitle>Advanced healthcare materials</jtitle><addtitle>Adv Healthc Mater</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>10</volume><issue>6</issue><spage>e2001591</spage><epage>n/a</epage><pages>e2001591-n/a</pages><issn>2192-2640</issn><eissn>2192-2659</eissn><abstract>Imbalance of metal ions in the wound microenvironment is a key factor that leads to delayed wound healing. However, single metal administration to enhance wound repair is usually not enough due to the overlapping nature of the wound healing phases. Herein, a facile freeze‐thawing strategy is developed to incorporate chitosan/ions hydrogel into medical gauzes to realize on‐demand release of multiple ions to accelerate wound healing. In vitro study reveals that the gauzes can temporally release multiple metal ions on demand, and the released metal ions show effectiveness in killing bacteria and expediting cell migration. In vivo studies demonstrate that the metal ions loaded gauzes can efficiently enhance infected wound healing. Further histological analysis find that these metal ion‐loaded gauzes accelerate wound healing by promoting granulation formation, collagen deposition and maturation, re‐epithelization, angiogenesis, and inhibiting inflammation via regulating the expression of inflammatory factors (e.g., tumor necrosis factor‐α) and polarization of macrophages. Thus, this novel metal ions delivery system has great potential in infected tissue repair and antibacterial applications.
Chitosan/metal ions hydrogels are coated to medical gauzes through a simple freeze‐thawing strategy to realize on‐demand release of multiple metal ions for improved wound healing by promoting granulation formation, collagen deposition and maturation, re‐epithelization, angiogenesis, and inhibiting inflammation via regulating the expression of inflammatory factors (e.g., tumor necrosis factor‐α ) and polarization of macrophages.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33320448</pmid><doi>10.1002/adhm.202001591</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-5177-0636</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2192-2640 |
| ispartof | Advanced healthcare materials, 2021-03, Vol.10 (6), p.e2001591-n/a |
| issn | 2192-2640 2192-2659 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2470280175 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Angiogenesis Antiinfectives and antibacterials Bandages Cell adhesion & migration Chitosan Collagen controlled release Freeze-thawing freeze‐thaw Granulation Hydrogels In vivo methods and tests Inflammation Ions Leukocyte migration Macrophages Melting Metal ions Microenvironments Repair Thawing Wound Healing |
| title | Freeze‐Thawing Chitosan/Ions Hydrogel Coated Gauzes Releasing Multiple Metal Ions on Demand for Improved Infected Wound Healing |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T03%3A51%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Freeze%E2%80%90Thawing%20Chitosan/Ions%20Hydrogel%20Coated%20Gauzes%20Releasing%20Multiple%20Metal%20Ions%20on%20Demand%20for%20Improved%20Infected%20Wound%20Healing&rft.jtitle=Advanced%20healthcare%20materials&rft.au=Xiao,%20Jian&rft.date=2021-03-01&rft.volume=10&rft.issue=6&rft.spage=e2001591&rft.epage=n/a&rft.pages=e2001591-n/a&rft.issn=2192-2640&rft.eissn=2192-2659&rft_id=info:doi/10.1002/adhm.202001591&rft_dat=%3Cproquest_cross%3E2470280175%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2501878147&rft_id=info:pmid/33320448&rfr_iscdi=true |