Neglected side effects to curative prostate cancer treatments
In this narrative review we summarize neglected side effects of curative intended treatment for prostate cancer. They include climacturia, arousal incontinence (AI), orgasmic disturbances such as altered orgasmic sensation, anorgasmia, and orgasm-associated pain (dysorgasmia), ejaculatory dysfunctio...
Gespeichert in:
| Veröffentlicht in: | International journal of impotence research 2021-05, Vol.33 (4), p.428-438 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 438 |
|---|---|
| container_issue | 4 |
| container_start_page | 428 |
| container_title | International journal of impotence research |
| container_volume | 33 |
| creator | Nolsøe, Alexander B. Jensen, Christian Fuglesang S. Østergren, Peter B. Fode, Mikkel |
| description | In this narrative review we summarize neglected side effects of curative intended treatment for prostate cancer. They include climacturia, arousal incontinence (AI), orgasmic disturbances such as altered orgasmic sensation, anorgasmia, and orgasm-associated pain (dysorgasmia), ejaculatory dysfunction, and morphological penile alterations in the form of shortening and deformity. Even though they have not received as much interest as erectile dysfunction (ED) or urinary incontinence, these side effects have been shown to negatively impact patient’s quality of life. They are common and rates of climacturia after radical prostatectomy (RP) range from 20% and 45%, less after external beam radiation therapy (EBRT). Decreased orgasmic sensation ranges from 3.9% to 60% after RP and between 36–57% after EBRT. Dysorgasmia ranges from 9.5–15% for both RP and EBRT. Anejculation after EBRT ranges from 11–71% and rates of penile shortening are reported between 0 and 100%. There are no internationally validated questionnaires that adequately asses these side effects. This is necessary if we are to align patient and partner expectations properly and consequently manage them optimally. Neglected side effects should be discussed with patients and their partners preoperatively, as they are associated with bother and may lead to patient’s avoiding sexual activity. |
| doi_str_mv | 10.1038/s41443-020-00386-4 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2470279851</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A662388699</galeid><sourcerecordid>A662388699</sourcerecordid><originalsourceid>FETCH-LOGICAL-c473t-501cc48ad48b3802ce40aa4b9ed0b25c1220da5bfb4ee2a146d1eff5a7fb14c93</originalsourceid><addsrcrecordid>eNp9kU1LHTEUhoMo9ar9Ay7KQKG4GXvyOcmiC5HWFkQ3dR0ymTPXkfmwSUbw3zfXa-u9IpJFOMnzvjknLyHHFE4pcP01CioEL4FBCblWpdghCyoqVUqhzS5ZgJGyNIbDPjmI8Q4ADFD1gexzzqlWvFqQb1e47NEnbIrYNVhg2-YqFmkq_Bxc6h6wuA9TTC5h4d3oMRQpoEsDjikekb3W9RE_Pu-H5ObH99_nP8vL64tf52eXpRcVT6UE6r3QrhG65hqYRwHOidpgAzWTnjIGjZN1WwtE5qhQDc2NSFe1NRXe8ENysvbNrfyZMSY7dNFj37sRpzlaJipgldGSZvTzK_RumsOYu7NMsjy0pGqDWroebTe2UwrOr0ztmVKMa63M6tnTN6i8Ghw6P43Ydvl8S_BlQ3CLrk-3cern1E1j3AbZGvT5b2PA1t6HbnDh0VKwq3DtOlybw7VP4VqRRZ-eR5vrAZv_kn9pZoCvgZivxiWGl9nfsf0LQvisuw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2528635161</pqid></control><display><type>article</type><title>Neglected side effects to curative prostate cancer treatments</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Nolsøe, Alexander B. ; Jensen, Christian Fuglesang S. ; Østergren, Peter B. ; Fode, Mikkel</creator><creatorcontrib>Nolsøe, Alexander B. ; Jensen, Christian Fuglesang S. ; Østergren, Peter B. ; Fode, Mikkel</creatorcontrib><description>In this narrative review we summarize neglected side effects of curative intended treatment for prostate cancer. They include climacturia, arousal incontinence (AI), orgasmic disturbances such as altered orgasmic sensation, anorgasmia, and orgasm-associated pain (dysorgasmia), ejaculatory dysfunction, and morphological penile alterations in the form of shortening and deformity. Even though they have not received as much interest as erectile dysfunction (ED) or urinary incontinence, these side effects have been shown to negatively impact patient’s quality of life. They are common and rates of climacturia after radical prostatectomy (RP) range from 20% and 45%, less after external beam radiation therapy (EBRT). Decreased orgasmic sensation ranges from 3.9% to 60% after RP and between 36–57% after EBRT. Dysorgasmia ranges from 9.5–15% for both RP and EBRT. Anejculation after EBRT ranges from 11–71% and rates of penile shortening are reported between 0 and 100%. There are no internationally validated questionnaires that adequately asses these side effects. This is necessary if we are to align patient and partner expectations properly and consequently manage them optimally. Neglected side effects should be discussed with patients and their partners preoperatively, as they are associated with bother and may lead to patient’s avoiding sexual activity.</description><identifier>ISSN: 0955-9930</identifier><identifier>EISSN: 1476-5489</identifier><identifier>DOI: 10.1038/s41443-020-00386-4</identifier><identifier>PMID: 33318637</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/699/2768/515 ; 692/700/784 ; Cancer ; Cancer surgery ; Cancer therapies ; Care and treatment ; Erectile dysfunction ; Erectile Dysfunction - etiology ; Humans ; Male ; Medicine ; Medicine & Public Health ; Mens health ; Orgasm ; Pain ; Penis ; Prostate cancer ; Prostatectomy - adverse effects ; Prostatic Neoplasms - surgery ; Prostatic Neoplasms - therapy ; Quality of Life ; Reproductive Medicine ; Review Article ; Risk factors ; rology ; Sexual disorders ; Side effects ; Urinary incontinence ; Urological surgery ; Urology</subject><ispartof>International journal of impotence research, 2021-05, Vol.33 (4), p.428-438</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2020</rights><rights>COPYRIGHT 2021 Nature Publishing Group</rights><rights>The Author(s), under exclusive licence to Springer Nature Limited 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-501cc48ad48b3802ce40aa4b9ed0b25c1220da5bfb4ee2a146d1eff5a7fb14c93</citedby><cites>FETCH-LOGICAL-c473t-501cc48ad48b3802ce40aa4b9ed0b25c1220da5bfb4ee2a146d1eff5a7fb14c93</cites><orcidid>0000-0002-8963-4581 ; 0000-0003-4762-039X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41443-020-00386-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41443-020-00386-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33318637$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nolsøe, Alexander B.</creatorcontrib><creatorcontrib>Jensen, Christian Fuglesang S.</creatorcontrib><creatorcontrib>Østergren, Peter B.</creatorcontrib><creatorcontrib>Fode, Mikkel</creatorcontrib><title>Neglected side effects to curative prostate cancer treatments</title><title>International journal of impotence research</title><addtitle>Int J Impot Res</addtitle><addtitle>Int J Impot Res</addtitle><description>In this narrative review we summarize neglected side effects of curative intended treatment for prostate cancer. They include climacturia, arousal incontinence (AI), orgasmic disturbances such as altered orgasmic sensation, anorgasmia, and orgasm-associated pain (dysorgasmia), ejaculatory dysfunction, and morphological penile alterations in the form of shortening and deformity. Even though they have not received as much interest as erectile dysfunction (ED) or urinary incontinence, these side effects have been shown to negatively impact patient’s quality of life. They are common and rates of climacturia after radical prostatectomy (RP) range from 20% and 45%, less after external beam radiation therapy (EBRT). Decreased orgasmic sensation ranges from 3.9% to 60% after RP and between 36–57% after EBRT. Dysorgasmia ranges from 9.5–15% for both RP and EBRT. Anejculation after EBRT ranges from 11–71% and rates of penile shortening are reported between 0 and 100%. There are no internationally validated questionnaires that adequately asses these side effects. This is necessary if we are to align patient and partner expectations properly and consequently manage them optimally. Neglected side effects should be discussed with patients and their partners preoperatively, as they are associated with bother and may lead to patient’s avoiding sexual activity.</description><subject>692/699/2768/515</subject><subject>692/700/784</subject><subject>Cancer</subject><subject>Cancer surgery</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Erectile dysfunction</subject><subject>Erectile Dysfunction - etiology</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mens health</subject><subject>Orgasm</subject><subject>Pain</subject><subject>Penis</subject><subject>Prostate cancer</subject><subject>Prostatectomy - adverse effects</subject><subject>Prostatic Neoplasms - surgery</subject><subject>Prostatic Neoplasms - therapy</subject><subject>Quality of Life</subject><subject>Reproductive Medicine</subject><subject>Review Article</subject><subject>Risk factors</subject><subject>rology</subject><subject>Sexual disorders</subject><subject>Side effects</subject><subject>Urinary incontinence</subject><subject>Urological surgery</subject><subject>Urology</subject><issn>0955-9930</issn><issn>1476-5489</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU1LHTEUhoMo9ar9Ay7KQKG4GXvyOcmiC5HWFkQ3dR0ymTPXkfmwSUbw3zfXa-u9IpJFOMnzvjknLyHHFE4pcP01CioEL4FBCblWpdghCyoqVUqhzS5ZgJGyNIbDPjmI8Q4ADFD1gexzzqlWvFqQb1e47NEnbIrYNVhg2-YqFmkq_Bxc6h6wuA9TTC5h4d3oMRQpoEsDjikekb3W9RE_Pu-H5ObH99_nP8vL64tf52eXpRcVT6UE6r3QrhG65hqYRwHOidpgAzWTnjIGjZN1WwtE5qhQDc2NSFe1NRXe8ENysvbNrfyZMSY7dNFj37sRpzlaJipgldGSZvTzK_RumsOYu7NMsjy0pGqDWroebTe2UwrOr0ztmVKMa63M6tnTN6i8Ghw6P43Ydvl8S_BlQ3CLrk-3cern1E1j3AbZGvT5b2PA1t6HbnDh0VKwq3DtOlybw7VP4VqRRZ-eR5vrAZv_kn9pZoCvgZivxiWGl9nfsf0LQvisuw</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Nolsøe, Alexander B.</creator><creator>Jensen, Christian Fuglesang S.</creator><creator>Østergren, Peter B.</creator><creator>Fode, Mikkel</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8963-4581</orcidid><orcidid>https://orcid.org/0000-0003-4762-039X</orcidid></search><sort><creationdate>20210501</creationdate><title>Neglected side effects to curative prostate cancer treatments</title><author>Nolsøe, Alexander B. ; Jensen, Christian Fuglesang S. ; Østergren, Peter B. ; Fode, Mikkel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-501cc48ad48b3802ce40aa4b9ed0b25c1220da5bfb4ee2a146d1eff5a7fb14c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>692/699/2768/515</topic><topic>692/700/784</topic><topic>Cancer</topic><topic>Cancer surgery</topic><topic>Cancer therapies</topic><topic>Care and treatment</topic><topic>Erectile dysfunction</topic><topic>Erectile Dysfunction - etiology</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mens health</topic><topic>Orgasm</topic><topic>Pain</topic><topic>Penis</topic><topic>Prostate cancer</topic><topic>Prostatectomy - adverse effects</topic><topic>Prostatic Neoplasms - surgery</topic><topic>Prostatic Neoplasms - therapy</topic><topic>Quality of Life</topic><topic>Reproductive Medicine</topic><topic>Review Article</topic><topic>Risk factors</topic><topic>rology</topic><topic>Sexual disorders</topic><topic>Side effects</topic><topic>Urinary incontinence</topic><topic>Urological surgery</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nolsøe, Alexander B.</creatorcontrib><creatorcontrib>Jensen, Christian Fuglesang S.</creatorcontrib><creatorcontrib>Østergren, Peter B.</creatorcontrib><creatorcontrib>Fode, Mikkel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of impotence research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nolsøe, Alexander B.</au><au>Jensen, Christian Fuglesang S.</au><au>Østergren, Peter B.</au><au>Fode, Mikkel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neglected side effects to curative prostate cancer treatments</atitle><jtitle>International journal of impotence research</jtitle><stitle>Int J Impot Res</stitle><addtitle>Int J Impot Res</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>33</volume><issue>4</issue><spage>428</spage><epage>438</epage><pages>428-438</pages><issn>0955-9930</issn><eissn>1476-5489</eissn><abstract>In this narrative review we summarize neglected side effects of curative intended treatment for prostate cancer. They include climacturia, arousal incontinence (AI), orgasmic disturbances such as altered orgasmic sensation, anorgasmia, and orgasm-associated pain (dysorgasmia), ejaculatory dysfunction, and morphological penile alterations in the form of shortening and deformity. Even though they have not received as much interest as erectile dysfunction (ED) or urinary incontinence, these side effects have been shown to negatively impact patient’s quality of life. They are common and rates of climacturia after radical prostatectomy (RP) range from 20% and 45%, less after external beam radiation therapy (EBRT). Decreased orgasmic sensation ranges from 3.9% to 60% after RP and between 36–57% after EBRT. Dysorgasmia ranges from 9.5–15% for both RP and EBRT. Anejculation after EBRT ranges from 11–71% and rates of penile shortening are reported between 0 and 100%. There are no internationally validated questionnaires that adequately asses these side effects. This is necessary if we are to align patient and partner expectations properly and consequently manage them optimally. Neglected side effects should be discussed with patients and their partners preoperatively, as they are associated with bother and may lead to patient’s avoiding sexual activity.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33318637</pmid><doi>10.1038/s41443-020-00386-4</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-8963-4581</orcidid><orcidid>https://orcid.org/0000-0003-4762-039X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0955-9930 |
| ispartof | International journal of impotence research, 2021-05, Vol.33 (4), p.428-438 |
| issn | 0955-9930 1476-5489 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2470279851 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | 692/699/2768/515 692/700/784 Cancer Cancer surgery Cancer therapies Care and treatment Erectile dysfunction Erectile Dysfunction - etiology Humans Male Medicine Medicine & Public Health Mens health Orgasm Pain Penis Prostate cancer Prostatectomy - adverse effects Prostatic Neoplasms - surgery Prostatic Neoplasms - therapy Quality of Life Reproductive Medicine Review Article Risk factors rology Sexual disorders Side effects Urinary incontinence Urological surgery Urology |
| title | Neglected side effects to curative prostate cancer treatments |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T04%3A04%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Neglected%20side%20effects%20to%20curative%20prostate%20cancer%20treatments&rft.jtitle=International%20journal%20of%20impotence%20research&rft.au=Nols%C3%B8e,%20Alexander%20B.&rft.date=2021-05-01&rft.volume=33&rft.issue=4&rft.spage=428&rft.epage=438&rft.pages=428-438&rft.issn=0955-9930&rft.eissn=1476-5489&rft_id=info:doi/10.1038/s41443-020-00386-4&rft_dat=%3Cgale_proqu%3EA662388699%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2528635161&rft_id=info:pmid/33318637&rft_galeid=A662388699&rfr_iscdi=true |