Genetic association study of a novel indel polymorphism in HSPA1B with the risk of sudden cardiac death in the Chinese populations

•The Indel variant rs3036297 correlates with SCD susceptibility in Chinese populations.•rs3036297 may regulate HSPA1B expression through interfering the binding of miR-134-5p.•rs3036297 may regulate HAL-DRB5 expression via cis-eQTL effect.•rs3036297 would be a potential marker for molecular diagnosi...

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Veröffentlicht in:	Forensic science international 2021-01, Vol.318, p.110637-110637, Article 110637
Hauptverfasser:	Yang, Zhenzhen, Zhang, Qing, Yu, Huan, Du, Hailin, Li, Lijuan, He, Yan, Zhu, Shaohua, Li, Chengtao, Zhang, Suhua, Luo, Bin, Gao, Yuzhen
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions Alleles Antigens Atherosclerosis Binding Chronic obstructive pulmonary disease Deoxyribonucleic acid Diagnosis DNA Forensic sciences Gene deletion Gene expression Gene polymorphism Genetic counseling Genetic factors Genetic screening Health risk assessment Heart Heat shock proteins Histocompatibility antigen HLA HLA-DRB5 HSPA1B Insertion Long-range interaction miR-134-5p miRNA Mutation Polymorphism Population genetics Populations Regression analysis Risk rs3036297 SCD Statistical analysis
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