Single-cell RNA sequencing of psoriatic skin identifies pathogenic Tc17 cell subsets and reveals distinctions between CD8+ T cells in autoimmunity and cancer

Psoriasis is an inflammatory, IL-17–driven skin disease in which autoantigen-induced CD8+ T cells have been identified as pathogenic drivers. Our study focused on comprehensively characterizing the phenotypic variation of CD8+ T cells in psoriatic lesions. We used single-cell RNA sequencing to compa...

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