New indomethacin analogs as selective COX‐2 inhibitors: Synthesis, COX‐1/2 inhibitory activity, anti‐inflammatory, ulcerogenicity, histopathological, and docking studies

New indomethacin analogs 4a–g, 5, 6, 8a, and 8b were synthesized to overcome the nonselectivity and ulcer liability of indomethacin. All newly synthesized compounds were more potent against cyclooxygenase 2 (COX‐2; IC50 value range: 0.09–0.4 μМ) as compared with celecoxib (IC50 = 0.89 μМ). Compounds...

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Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 2021-04, Vol.354 (4), p.e2000328-n/a
Hauptverfasser:	Abdellatif, Khaled R. A., Abdelall, Eman K. A., Elshemy, Heba A. H., El‐Nahass, El‐Shaymaa, Abdel‐Fattah, Maha M., Abdelgawad, Yasmin Y. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	anti‐inflammatory activity COX‐1 COX‐2 histopathology indomethacin Ulcers
Online-Zugang:	Volltext
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