Bone marrow mesenchymal stem cells‐derived exosomes reduce Aβ deposition and improve cognitive function recovery in mice with Alzheimer's disease by activating sphingosine kinase/sphingosine‐1‐phosphate signaling pathway

Exosomes are associated with the development and progression of Alzheimer's disease (AD), although the impact of these extracellular vesicles in brain pathological condition remains incompletely understood. Therefore, this study aimed to investigate the role and mechanism of exosomes signaling...

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Veröffentlicht in:	Cell biology international 2021-04, Vol.45 (4), p.775-784
Hauptverfasser:	Wang, Xinhui, Yang, Guojie
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyloid Amyloid precursor protein Aβ deposition Bone marrow Cognitive ability cognitive function Enzyme inhibitors Exosomes Extracellular vesicles Kinases Memory Mesenchymal stem cells Neprilysin Neurodegenerative diseases Observational learning Presenilin 1 senile plaque Signal transduction Spatial discrimination learning Spatial memory Sphingosine kinase sphingosine kinase/sphingosine‐1‐phosphate Stem cell transplantation Stem cells Transgenic mice β-Site APP-cleaving enzyme 1
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