IL-6 as a major regulator of MDSC activity and possible target for cancer immunotherapy

•IL-6 is a crucial regulator of myeloid-derived suppressor cells during tumor progression.•IL-6 blockade could be considered as an immunotherapeutic strategy in cancer.•Immunostimulatory effects of IL-6 in cancer should not be neglected. Myeloid-derived suppressor cells (MDSC) are generated during t...

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Veröffentlicht in:	Cellular immunology 2021-01, Vol.359, p.104254-104254, Article 104254
Hauptverfasser:	Weber, Rebekka, Groth, Christopher, Lasser, Samantha, Arkhypov, Ihor, Petrova, Vera, Altevogt, Peter, Utikal, Jochen, Umansky, Viktor
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer IL-6 Immunosuppression Immunotherapy Myeloid-derived suppressor cells
Online-Zugang:	Volltext
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