HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications

Ferroptosis is a recently discovered form of programed cell death caused by the metabolically regulated lipid peroxidation and holds promise for cancer treatment, but its regulatory mechanisms remain elusive. In this study, we observe that lactate-rich liver cancer cells exhibit enhanced resistance...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Cell reports (Cambridge) 2020-12, Vol.33 (10), p.108487-108487, Article 108487
Hauptverfasser:	Zhao, Youbo, Li, Menghuan, Yao, Xuemei, Fei, Yang, Lin, Zhenghong, Li, Zhengguo, Cai, Kaiyong, Zhao, Yanli, Luo, Zhong
Format:	Artikel
Sprache:	eng
Schlagworte:	ferroptosis lactate MCT1 tumor microenvironment tumor therapy
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!