Machine Learning of Hematopoietic Stem Cell Divisions from Paired Daughter Cell Expression Profiles Reveals Effects of Aging on Self-Renewal

Changes in stem cell activity may underpin aging. However, these changes are not completely understood. Here, we combined single-cell profiling with machine learning and in vivo functional studies to explore how hematopoietic stem cell (HSC) divisions patterns evolve with age. We first trained an ar...

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Veröffentlicht in:Cell systems 2020-12, Vol.11 (6), p.640-652.e5
Hauptverfasser: Arai, Fumio, Stumpf, Patrick S., Ikushima, Yoshiko M., Hosokawa, Kentaro, Roch, Aline, Lutolf, Matthias P., Suda, Toshio, MacArthur, Ben D.
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Sprache:eng
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