Intranasal administration of small extracellular vesicles derived from mesenchymal stem cells ameliorated the experimental autoimmune encephalomyelitis

•Both MSC-SEV and MSC reduced clinical score in EAE mice.•Intranasal MSC-SEV alleviated clinical score more efficiently than intranasal MSC.•Reduced clinical score was accompanied by elevated immunomodulatory responses. Experimental autoimmune encephalomyelitis (EAE) is a mouse model for the human m...

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Veröffentlicht in:	International immunopharmacology 2021-01, Vol.90, p.107207-107207, Article 107207
Hauptverfasser:	Fathollahi, Anwar, Hashemi, Seyed Mahmoud, Haji Molla Hoseini, Mostafa, Tavakoli, Sajjad, Farahani, Elnaz, Yeganeh, Farshid
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens CD25 antigen Cell culture Cell proliferation Cells, Cultured Central nervous system Cytokines Cytokines - metabolism Encephalomyelitis Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - metabolism Encephalomyelitis, Autoimmune, Experimental - pathology Encephalomyelitis, Autoimmune, Experimental - surgery Experimental allergic encephalomyelitis Experimental autoimmune encephalomyelitis Extracellular vesicles Extracellular Vesicles - immunology Extracellular Vesicles - metabolism Extracellular Vesicles - transplantation Female Foxp3 protein Gene Expression Regulation Health services Immunization Immunomodulation Immunoregulation Inflammation Inflammation Mediators - metabolism Interleukin 10 Intranasal administration Lesions Lymphocytes Lymphocytes T Mesenchymal stem cell Mesenchymal Stem Cell Transplantation Mesenchymal stem cells Mesenchymal Stem Cells - immunology Mesenchymal Stem Cells - metabolism Mice Mice, Inbred C57BL Multiple sclerosis Myelination Signs and symptoms Small extracellular vesicles Spinal Cord - immunology Spinal Cord - metabolism Spinal Cord - pathology Splenocytes Stem cell transplantation Stem cells T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Transcription factors
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