Experimental challenge of a North American bat species, big brown bat (Eptesicus fuscus), with SARS‐CoV‐2
The recently emerged novel coronavirus, SARS‐CoV‐2, is phylogenetically related to bat coronaviruses (CoVs), specifically SARS‐related CoVs from the Eurasian bat family Rhinolophidae. As this human pandemic virus has spread across the world, the potential impacts of SARS‐CoV‐2 on native North Americ...
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Veröffentlicht in: | Transboundary and emerging diseases 2021-11, Vol.68 (6), p.3443-3452 |
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creator | Hall, Jeffrey S. Knowles, Susan Nashold, Sean W. Ip, Hon S. Leon, Ariel E. Rocke, Tonie Keller, Saskia Carossino, Mariano Balasuriya, Udeni Hofmeister, Erik |
description | The recently emerged novel coronavirus, SARS‐CoV‐2, is phylogenetically related to bat coronaviruses (CoVs), specifically SARS‐related CoVs from the Eurasian bat family Rhinolophidae. As this human pandemic virus has spread across the world, the potential impacts of SARS‐CoV‐2 on native North American bat populations are unknown, as is the ability of North American bats to serve as reservoirs or intermediate hosts able to transmit the virus to humans or to other animal species. To help determine the impacts of the pandemic virus on North American bat populations, we experimentally challenged big brown bats (Eptesicus fuscus) with SARS‐CoV‐2 under BSL‐3 conditions. We inoculated the bats both oropharyngeally and nasally, and over the ensuing three weeks, we measured infectivity, pathology, virus concentrations in tissues, oral and rectal virus excretion, virus transmission, and clinical signs of disease. We found no evidence of SARS‐CoV‐2 infection in any examined bat, including no viral excretion, no transmission, no detectable virus in tissues, and no signs of disease or pathology. Based on our findings, it appears that big brown bats are resistant to infection with the SARS‐CoV‐2. The potential susceptibility of other North American bat species to SARS‐CoV‐2 remains to be investigated. |
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As this human pandemic virus has spread across the world, the potential impacts of SARS‐CoV‐2 on native North American bat populations are unknown, as is the ability of North American bats to serve as reservoirs or intermediate hosts able to transmit the virus to humans or to other animal species. To help determine the impacts of the pandemic virus on North American bat populations, we experimentally challenged big brown bats (Eptesicus fuscus) with SARS‐CoV‐2 under BSL‐3 conditions. We inoculated the bats both oropharyngeally and nasally, and over the ensuing three weeks, we measured infectivity, pathology, virus concentrations in tissues, oral and rectal virus excretion, virus transmission, and clinical signs of disease. We found no evidence of SARS‐CoV‐2 infection in any examined bat, including no viral excretion, no transmission, no detectable virus in tissues, and no signs of disease or pathology. Based on our findings, it appears that big brown bats are resistant to infection with the SARS‐CoV‐2. The potential susceptibility of other North American bat species to SARS‐CoV‐2 remains to be investigated.</description><identifier>ISSN: 1865-1674</identifier><identifier>EISSN: 1865-1682</identifier><identifier>DOI: 10.1111/tbed.13949</identifier><identifier>PMID: 33295095</identifier><language>eng</language><publisher>Germany: Hindawi Limited</publisher><subject>Animal species ; Bats ; big brown bats ; challenge ; Chiroptera ; coronavirus ; Coronaviruses ; COVID-19 ; Disease transmission ; Eptesicus fuscus ; Excretion ; Infectivity ; Pandemics ; Pathology ; Phylogeny ; Populations ; SARS‐CoV‐2 ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Species ; susceptibility ; Viral diseases ; Viruses</subject><ispartof>Transboundary and emerging diseases, 2021-11, Vol.68 (6), p.3443-3452</ispartof><rights>Published 2020. This article is a U.S. Government work and is in the public domain in the USA.</rights><rights>Copyright © 2021 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3939-2d1ba558e51bd3b7f61fa54dc80cb866a81460dac5b231b61226e36e0e34e8493</citedby><cites>FETCH-LOGICAL-c3939-2d1ba558e51bd3b7f61fa54dc80cb866a81460dac5b231b61226e36e0e34e8493</cites><orcidid>0000-0001-5599-2826</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ftbed.13949$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ftbed.13949$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33295095$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hall, Jeffrey S.</creatorcontrib><creatorcontrib>Knowles, Susan</creatorcontrib><creatorcontrib>Nashold, Sean W.</creatorcontrib><creatorcontrib>Ip, Hon S.</creatorcontrib><creatorcontrib>Leon, Ariel E.</creatorcontrib><creatorcontrib>Rocke, Tonie</creatorcontrib><creatorcontrib>Keller, Saskia</creatorcontrib><creatorcontrib>Carossino, Mariano</creatorcontrib><creatorcontrib>Balasuriya, Udeni</creatorcontrib><creatorcontrib>Hofmeister, Erik</creatorcontrib><title>Experimental challenge of a North American bat species, big brown bat (Eptesicus fuscus), with SARS‐CoV‐2</title><title>Transboundary and emerging diseases</title><addtitle>Transbound Emerg Dis</addtitle><description>The recently emerged novel coronavirus, SARS‐CoV‐2, is phylogenetically related to bat coronaviruses (CoVs), specifically SARS‐related CoVs from the Eurasian bat family Rhinolophidae. As this human pandemic virus has spread across the world, the potential impacts of SARS‐CoV‐2 on native North American bat populations are unknown, as is the ability of North American bats to serve as reservoirs or intermediate hosts able to transmit the virus to humans or to other animal species. To help determine the impacts of the pandemic virus on North American bat populations, we experimentally challenged big brown bats (Eptesicus fuscus) with SARS‐CoV‐2 under BSL‐3 conditions. We inoculated the bats both oropharyngeally and nasally, and over the ensuing three weeks, we measured infectivity, pathology, virus concentrations in tissues, oral and rectal virus excretion, virus transmission, and clinical signs of disease. We found no evidence of SARS‐CoV‐2 infection in any examined bat, including no viral excretion, no transmission, no detectable virus in tissues, and no signs of disease or pathology. Based on our findings, it appears that big brown bats are resistant to infection with the SARS‐CoV‐2. The potential susceptibility of other North American bat species to SARS‐CoV‐2 remains to be investigated.</description><subject>Animal species</subject><subject>Bats</subject><subject>big brown bats</subject><subject>challenge</subject><subject>Chiroptera</subject><subject>coronavirus</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Disease transmission</subject><subject>Eptesicus fuscus</subject><subject>Excretion</subject><subject>Infectivity</subject><subject>Pandemics</subject><subject>Pathology</subject><subject>Phylogeny</subject><subject>Populations</subject><subject>SARS‐CoV‐2</subject><subject>Severe acute respiratory syndrome</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Species</subject><subject>susceptibility</subject><subject>Viral diseases</subject><subject>Viruses</subject><issn>1865-1674</issn><issn>1865-1682</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kctOGzEUhi1Exa1seABkiQ1UhPoyduxlGkJBQkVqoFvL9pxJBs2t4xkFdjwCz9gnwTChCxZ44WMdff50dH6EDig5o_F87xykZ5TrRG-gHaqkGFGp2Ob_9zjZRrsh3BMiiZZiC21zzrQgWuygcvbQQJuXUHW2wH5piwKqBeA6wxb_qttuiSdlBLytsLMdDg34HMIpdvkCu7ZeDe3jWdNByH0fcNaHWE5O8SqPn-eT3_N_T8_T-k-82Vf0JbNFgP113UN3F7Pb6eXo-ubn1XRyPfJccz1iKXVWCAWCupS7cSZpZkWSekW8U1JaRRNJUuuFY5w6SRmTwCUQ4AmoRPM9dDx4m7b-20PoTJkHD0VhK6j7YFgio2bMtYro0Qf0vu7bKk5nmNCaEs0UjdS3gfJtHUILmWni0mz7aCgxryGY1xDMWwgRPlwre1fG7jv6vvUI0AFY5QU8fqIytz9m54P0BWfukcQ</recordid><startdate>202111</startdate><enddate>202111</enddate><creator>Hall, Jeffrey S.</creator><creator>Knowles, Susan</creator><creator>Nashold, Sean W.</creator><creator>Ip, Hon S.</creator><creator>Leon, Ariel E.</creator><creator>Rocke, Tonie</creator><creator>Keller, Saskia</creator><creator>Carossino, Mariano</creator><creator>Balasuriya, Udeni</creator><creator>Hofmeister, Erik</creator><general>Hindawi Limited</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5599-2826</orcidid></search><sort><creationdate>202111</creationdate><title>Experimental challenge of a North American bat species, big brown bat (Eptesicus fuscus), with SARS‐CoV‐2</title><author>Hall, Jeffrey S. ; Knowles, Susan ; Nashold, Sean W. ; Ip, Hon S. ; Leon, Ariel E. ; Rocke, Tonie ; Keller, Saskia ; Carossino, Mariano ; Balasuriya, Udeni ; Hofmeister, Erik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3939-2d1ba558e51bd3b7f61fa54dc80cb866a81460dac5b231b61226e36e0e34e8493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animal species</topic><topic>Bats</topic><topic>big brown bats</topic><topic>challenge</topic><topic>Chiroptera</topic><topic>coronavirus</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Disease transmission</topic><topic>Eptesicus fuscus</topic><topic>Excretion</topic><topic>Infectivity</topic><topic>Pandemics</topic><topic>Pathology</topic><topic>Phylogeny</topic><topic>Populations</topic><topic>SARS‐CoV‐2</topic><topic>Severe acute respiratory syndrome</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Species</topic><topic>susceptibility</topic><topic>Viral diseases</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hall, Jeffrey S.</creatorcontrib><creatorcontrib>Knowles, Susan</creatorcontrib><creatorcontrib>Nashold, Sean W.</creatorcontrib><creatorcontrib>Ip, Hon S.</creatorcontrib><creatorcontrib>Leon, Ariel E.</creatorcontrib><creatorcontrib>Rocke, Tonie</creatorcontrib><creatorcontrib>Keller, Saskia</creatorcontrib><creatorcontrib>Carossino, Mariano</creatorcontrib><creatorcontrib>Balasuriya, Udeni</creatorcontrib><creatorcontrib>Hofmeister, Erik</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transboundary and emerging diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hall, Jeffrey S.</au><au>Knowles, Susan</au><au>Nashold, Sean W.</au><au>Ip, Hon S.</au><au>Leon, Ariel E.</au><au>Rocke, Tonie</au><au>Keller, Saskia</au><au>Carossino, Mariano</au><au>Balasuriya, Udeni</au><au>Hofmeister, Erik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental challenge of a North American bat species, big brown bat (Eptesicus fuscus), with SARS‐CoV‐2</atitle><jtitle>Transboundary and emerging diseases</jtitle><addtitle>Transbound Emerg Dis</addtitle><date>2021-11</date><risdate>2021</risdate><volume>68</volume><issue>6</issue><spage>3443</spage><epage>3452</epage><pages>3443-3452</pages><issn>1865-1674</issn><eissn>1865-1682</eissn><abstract>The recently emerged novel coronavirus, SARS‐CoV‐2, is phylogenetically related to bat coronaviruses (CoVs), specifically SARS‐related CoVs from the Eurasian bat family Rhinolophidae. As this human pandemic virus has spread across the world, the potential impacts of SARS‐CoV‐2 on native North American bat populations are unknown, as is the ability of North American bats to serve as reservoirs or intermediate hosts able to transmit the virus to humans or to other animal species. To help determine the impacts of the pandemic virus on North American bat populations, we experimentally challenged big brown bats (Eptesicus fuscus) with SARS‐CoV‐2 under BSL‐3 conditions. We inoculated the bats both oropharyngeally and nasally, and over the ensuing three weeks, we measured infectivity, pathology, virus concentrations in tissues, oral and rectal virus excretion, virus transmission, and clinical signs of disease. We found no evidence of SARS‐CoV‐2 infection in any examined bat, including no viral excretion, no transmission, no detectable virus in tissues, and no signs of disease or pathology. Based on our findings, it appears that big brown bats are resistant to infection with the SARS‐CoV‐2. The potential susceptibility of other North American bat species to SARS‐CoV‐2 remains to be investigated.</abstract><cop>Germany</cop><pub>Hindawi Limited</pub><pmid>33295095</pmid><doi>10.1111/tbed.13949</doi><tpages>2</tpages><orcidid>https://orcid.org/0000-0001-5599-2826</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Animal species Bats big brown bats challenge Chiroptera coronavirus Coronaviruses COVID-19 Disease transmission Eptesicus fuscus Excretion Infectivity Pandemics Pathology Phylogeny Populations SARS‐CoV‐2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Species susceptibility Viral diseases Viruses |
title | Experimental challenge of a North American bat species, big brown bat (Eptesicus fuscus), with SARS‐CoV‐2 |
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